Donald Price - Recent Papers

Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC: BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4:233-234, 2001. [PDF]

Li T, Ma G, Cai H, Price DL, Wong PC: Nicastrin is required for assembly of presenilin/g-secretase complexes to mediate Notch Signaling, and processing and trafficking of beta-APP in mammals. J. of Neurosci. 23: 3272-3277, 2003. [PDF]

Ma G, Li T, Price DL, Wong PC. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 25(1)192-198, 2005. [PDF]

Laird F, Cai H, Savonenko A, He K, Melnikova T, Wen H, Chiang H, Xu G, Borchelt D, Price D, Lee H, Wong P: BACE1, a Major Determinant of Selective Vulnerability of the Brain to Aβ Amyloidogenesis, is Essential for Cognitive, Emotional and Synaptic Functions. J. Neurosci. 25(50),11693-709, 2005. [PDF]

Martin L, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK.  Parkinson’s Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondria Degeneration and Cell Death. J. Neurosci. 25 (50): 2005.

Savonenko AV, Laird FM, Troncoso JC, Wong PC, Price DL.  Role of Alzheimer's disease models in designing and testing experimental therapeutics. Drug Discovery Today: Disease Models, 2 (4): 305-312, 2005

Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK: Parkinson’s Disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26(1), 41-50, 2006. [PDF]

Lai C, Xie C, McCormack S, Chiang H-C, Michalak M, Lin X, Chandran J, Shim H. Shimoji M, Cookson M, Huganir R, Rothstein J, Price D, Wong PC, Martin,L, Zhu J and Cai,H: ALS2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor Trafficking.  J. Neurosci. 26: 11798-11806, 2006.  [PDF]

Litvan I, Halliday G, Hallett M, Goetz CG, Rocca W, Duyckaerts C, Ben-Shlomo Y, Dickson DW, Lang EA, Chesselet M-F, Langston WJ, Di Monte DA, Gasser T, Hagg T, Hardy J, Jenner P, Melamed E, Myers RH, Parker Jr. D, Price DL. Critical Issues on the Etiopathogenesis of Parkinson Disease and Suggestions for Future Research (Pt I), JNEN, 66(4): 251-257, 2007.  [PDF]

Litvan I, Chesselet M-F, Gasser T, Di Monte DA, Parker Jr. D, Hagg T, Hardy J, Jenner P, Myers RH, Price DL, Hallett M, Langston WJ, Lang AE, Halliday G, Rocca W, Duyckaerts C, Dickson DW, Ben-Shlomo Y, Goetz CG, Melamed E. Critical Issues on the Etiopathogenesis of Parkinson Disease and Suggestions for Future Research (Part II), JNEN, 66(5):329-336, 2007.  [PDF]

Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC: Moderate reduction of g-secretase attenuates amyloid burden and limits mechanism-based liabilities.  J. Neuroscience, 27(40): 10849-10859, 2007. 

Li T, Wen H, Brayton C, Das P, Smithson, LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG and Wong

PC: EGFR and Notch pathways participate in the tumor suppressor function of γ-Secretase.  J. Biol. Chem.

282:32264-32273, 2007.

Laird F, Farah M, Ackerley S, Hoke A, Maragakis NJ, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC: Motor

neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J.

Neuroscience 28(9), Feb 27, 2008.

Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC: Alteration of BACE1-dependent NRG1/ErbB4

signaling and schizophrenia-like phenotypes in BACE1 null mice. PNAS, 105(14):5585-5590.