Elizabeth O'Hearn - Recent Papers

O'Hearn, E., D.B. Long and M.E. Molliver.  Ibogaine induces glial activation in parasagittal zones of the cerebellum.  NeuroReport 4:299-302 (1993).

O'Hearn, E. and M.E. Molliver.  Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline.  Neuroscience 55:303-310 (1993).

O’Hearn, E. and M.E. Molliver.  Excitotoxic insult due to ibogaine leads to delayed induction of neuronal NOS in Purkinje cells.  NeuroReport 6:1611-1616 (1995).

O’Hearn, E. and M.E. Molliver.  The olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells: a model of indirect, trans-synaptic excitotoxicity. 

J. Neurosci. 17(22):8828-8841 (1997).

O’Hearn, E. and M.E. Molliver.  “Neurotoxins and neuronal death – an animal model of excitotoxicity.” In V. Koliatsos and R. Ratan, Eds., Cell Death in Diseases of the Nervous System, Humana Press, Towata, NJ, pp. 221-245, (1999).

O’Hearn, E., S.E. Holmes, P.C. Calvert, C.A. Ross, and R.L. Margolis. SCA-12: Tremor with cerebellar and cortical atrophy is associated with a CAG repeat expansion. Neurology 56: 299-303 (2001).

Margolis, R.L., E. O’Hearn, A. Rosenblatt, V. Willour, S.E. Holmes, M.L. Franz, C. Callahan, H.S. Hwang, J.C. Troncoso, and C.A. Ross. A disorder similar to Huntington’s disease is associated with a novel CAG repeat expansion. Ann. Neurol. 50:373-380 (2001).

Holmes, S.E., E. O’Hearn, A. Rosenblatt, C. Callahan, H.S. Hwang, R.G. Ingersoll-Ashworth, A. Fleisher, G. Stevanin, A. Brice, N.T. Potter, C.A. Ross, R.L. Margolis. A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2. Nat. Genet. 29:377-8 (2001).

Welsh, J.P., G. Yuen, D.G. Placantonakis, T. Vu, F. Haiss, E. O’Hearn, M.E. Molliver, and S.A. Aicher. Why do Purkinje cells die so easily after global brain ischemia? The cerebellar contribution to post-hypoxic myoclonus. Adv. Neurology 89:331-59 (2002).

O’Hearn, E. and M.E. Molliver. Administration of a non-NMDA antagonist, GYKI 52466, increases excitotoxic Purkinje cell degeneration caused by ibogaine. Neuroscience 127:373-383 (2004).

Bahl, S., K. Virdi, U. Mittal, M.P. Sachdeva, A.K. Kalla, S.E. Holmes, E. O’Hearn, R.L. Margolis, S. Jain, A.K. Srivastava, and M. Mukerji.  Evidence of a common founder for SCA12 in the Indian population. Ann. Hum. Genet. 69:1-7 (2005).

Holmes, S.E., E. O’Hearn, N. Cortez-Apreza, H.S. Hwang, C.A. Ross, S. Strack, and R.L. Margolis. Spinocerebellar Ataxia 12 (SCA12). In R. Wells and T. Ashizawa, Eds. Genetic Instabilities and Neurological Diseases, Elsevier, pp. 461-473 (2006).

O’Hearn, E. Inherited Cerebellar Ataxia. In R.T. Johnson, J.W. Griffin, and J.C. McArthur, Eds. Current Therapy in Neurologic Disease, 7th Ed. Mosby Elsevier, pp. 295-302 (2006).