Jeffrey Rothstein - Recent Papers

Nargi-Aizenman JL, Havert MB, Zhang M, Irani DN, Rothstein JD, Griffin DE. Glutamate receptor antagonists protect from virus-induced neural degeneration. Ann.Neurol. 2004; 55:541-549. [PDF]

Maragakis NJ, Rothstein JD. Glutamate transporters: animal models to neurologic disease. Neurobiol.Dis. 2004; 15:461-473.  [PDF]

Huang YH, Dykes-Hoberg M, Tanaka K, Rothstein JD, Bergles DE. Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. J.Neurosci. 2004; 24:103-111 [PDF]

Reagan LP, Rosell DR, Wood GE, Spedding M, Munoz C, Rothstein J, et al. Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine. Proceedings of the National Academy of Sciences 2004; 101: 2170-2184. [PDF]

Rothstein JD. Of mice and men: reconciling preclinical ALS mouse studies and human clinical trials. Ann.Neurol. 2003; 53:423-426. [PDF]

Son M, Cloyd CD, Rothstein JD, Rajendran B, Elliott JL. Aggregate formation in Cu,Zn superoxide dismutase-related proteins. J.Biol.Chem. 2003; 278:14331-14336. [PDF]

Rothstein JD, Snyder EY. Reality and immortality-neural stem cells for therapies. Nat.Biotechnol. 2004; 22:283-285. [PDF]

Harper JM, Krishnan C, Darman JS, Deshpande DM, Peck S, Shats I, et al. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc.Natl.Acad.Sci.U.S.A 2004; 101:7123-7128. [PDF]

Huang YH, Sinha SR, Tanaka K, Rothstein JD, Bergles DE. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J.Neurosci. 2004; 24:4551-4559. [PDF]

Jian Liu, Concepción Lillo, P. Andreas Jonsson, Christopher M. Ward, Jamuna R. Subramaniam, Jeffery D. Rothstein, Stefan Marklund, Peter M. Andersen, Thomas Brännström, Philip C. Wong, David S. Williams, and Don W. Cleveland, Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron 2004. 43, 5-17. [PDF]

Lin CLG, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, and Rothstein JD. Modulation of the neuronal glutamate transporter EAAC1 by an interacting protein GTRAP3-18.  Nature, 2001, 410:84-88.  [PDF]

Jackson M., Song W., Liu MY, Jin L., Dykes-Hoberg M., Lin CLG, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature, 2001, 401:89-93.  [PDF]

Kerr,D.A., Llado,J., Shamblott,M.J., Maragakis,N.J., Irani,D.N., Crawford,T.O., Krishnan,C., Dike,S., Gearhart,J.D., and Rothstein,J.D. (2003). Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. J.Neurosci. 23, 5131-5140.  [PDF]

Jerònia Lladó, C. Heggeli, E. Snyder and Jeffrey D. Rothstein. Neural stem cells are neurotrophic and neuroprotectant to motoneurons, in vitro and in vivo. Molecular Cellular Neuroscience, 2004, 27322-331.  [PDF]

Deshpande DM, Kim YS, Martinez T, et al. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol 2006;60:32-44.  [PDF]
 
Cudkowicz ME, Shefner JM, Schoenfeld DA, et al. Trial of celecoxib in amyotrophic lateral sclerosis. Ann Neurol 2006;60:22-31.  [PDF]

JD. Rothstein, S.Patel, M.R. Regan, C.Haenggeli, Y.H. Huang, D.E. Bergles, L. Jin,  M. Dykes Hoberg, S. Vidensky, D.S. Chung, S. Vang Toan, L.I. Bruijn, Z. Su, P. Gupta, & P. B. Fisher. β Lactam Antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 2005, 433: 73-77.  [PDF]

Ikeda Y.,Dick KA, Weatherspoon MR, Gincel D,Armburst K, Dalton JC, Stevanin G, Dürr A, Zühlke C, Bürk K, Clark HB, Brice A, Rothstein JD, Schut LJ, Day JW, Ranum LPW. Spectrin mutations cause spinocerebellar ataxia type 5. Nature Genetics, 2006,38:184-190.  [PDF]