John Laterra - Recent Papers

Reznik TE, Sang Y, Ma Y, Abounader RA, Rosen EM, Xia S and Laterra J.  Transcription- dependent epidermal growth factor receptor activation by hepatocyte growth factor, Mol Cancer Res, 6:139-150, 2008.

Zhang Y, Bressler JP, Neal J, Lal B, Bhang H-EC, Laterra J*, Pomper MG*.  ABCG2/BCRP expression modulates D-Luciferin based bioluminescence imaging. Cancer Res, 67:9389-9397, 2007. *contributed equally to this publication.

Xia S, Li Y, Rosen EM, Laterra J.  Robotoxic stress sensitizes glioblastoma cells to death receptor induced apoptosis: Requirements for c-jun NH2-terminal kinase and Bim, Mol Cancer Res, 5: 783-792, 2007.

Xu J, Gao M. Fan S, Meng Q, Goldberg ID, Abounader R, Ressom H, Laterra J, Rosen, EM. Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells. Oncogene, 2006, 26:2925-2938, 2007

Gerber DE, Laterra J. Emerging monoclonal antibody therapies for malignant gliomas. Expert Opin Investig Drugs, 16:477-494, 2007.

Kim KJ, Wang L, Su, YC, Gillespie GY, Salhotra A, Lal B and Laterra J. Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res, 12(4):1292-1298, 2006.

Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner E, Eberhart C, Laterra J and Abounader R.  The scatter factor/

hepatocyte growth factor: c-Met pathway in human embryonal CNS tumor malignancy. Cancer Res, 54:9355-9362, 2005.

Beckner ME, Gobbel GT, Abounader R, Burovic F, Agostino NR, Laterra J and Pollack IF.  Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.  Lab Invest, 85:1457-1470, 2006.

Xia, S and Laterra J. Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells. Biochem Biophys Res Com, 345:1358-1364, 2006.

Xia S and Laterra J. Sensitization of glioma cells to Fas-dependent apoptosis by chemotherapy-induced oxidative stress. Cancer Res, 65:5248-5255, 2005.

Lal B, Xia S, Abounader R and Laterra J. Targeting the c-Met pathway potentiates glioblastoma responses to g-radiation. Clin Cancer Res, 11:4479-4486, 2005.

Abounader R and Laterra J.  Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis.  Neuro-Oncology, 7:436-451, 2005.

Abounader R, Reznik T, Russell JC, Rosen EM, and Laterra J. Regulation of c-Met dependent gene expression by PTEN. Oncogene, 23:9173-9182, 2004.

Hossain MA, Russell JC, Miknyoczki B, Lal B and Laterra J. Vascular endothelial growth factor mediates vasogenic edema formation in acute lead encephalopathy. Annals of Neurology, 55:660-667, 2004.

Madden SL, Stan R-V, Cook BP, Nacht M, Jiang Y, Dufault MR, Zhang X, Zhang W, Walter-Yohrling J, Rouleau C, Akmaev VR, Wang CJ, Weber WD, Boutin P, Roy A, Shankara S, Callahan MR, Cao X, St. Martin, TB, Roberts BL, Teicher BA, Klinger KW, Lucey B, Laterra J and Walter KA. Vascular gene expression in non-neoplastic and malignant brain. Am. J. Pathol.,
165:601-608, 2004.

Hossain MA, Russell JC, O’Brien R, Laterra J. Neuronal pentraxin 1: A novel mediator of hypoxic ischemic brain injury. J Neurosci, 24:4187-4196, 2004.

Su W, Gutmann DH, Perry A, Abounader R, Laterra J and Sherman LS.  CD44-Independent Hepatocyte Growth Factor/c-Met Autocrine Loop Promotes Malignant Peripheral Nerve Sheath Tumor Cell Invasion In Vitro.  Glia, 45:297-306, 2004. 

Jiang WG, Grimshaw D, Martin TA, Davis G, Parr C, Watkins G, Lane J, Abounader R, Laterra J,  and Mansee RE.  Reduction of stromal fibroblast-induced mammary tumor growth by retroviral ribozyme transgenes to HGF/SF and its receptor, c-Met.  Clin Cancer Research, 9:4274-4281, 2003.

Hossain MA, Bailone JC, Gomes R, and Laterra J.  Neuroprotection by scatter factor/hepatocyte growth factor and FGF-1 in cerebellar granule neurons is phosphatidylinositol 3-kinase/Akt-dependent and MAPK/CREB-independent. J Neurochem, 81:365-378, 2002.

Walter K, Hossain MA, Luddy C, Goel N, Reznik TE, Laterra J: Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G1 is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription. Mol. Cell. Biol. 22:2703-2715, 2002. [PDF]

Bouton MLS, Hossain MA, Frelin LP, Laterra J and Pevsner J: Microarray analysis of differential gene expression in lead treated astrocytes. Tox Appl Pharm, 176:34-53, 2001.

Jiang WG, Grimshaw D, Lane J, Martin TA, Abounader R, Laterra J and Mansel RE. A hammerhead ribozyme suppresses expression of HGF/SF receptor, c-met, and reduces migration and invasiveness of breast cancer cells. Clin Cancer Res, 7:2555-2562, 2001.

Abounader R, Ranganathan S, Kim BYS, Nichols C and Laterra J: Signaling pathways in the induction of c-met expression by its ligand SF/HGF in human glioblastoma, J. Neurochem, 76:1497-1508, 2001.

Abounader R, Lal B, Luddy C, Koe G, Davidson B, Rosen EM, Latera J: In vivo targeting of SF/HGF and c-Met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes tumor apoptosis. Faseb J Express, published online 11/29/01.  [PDF]

Guerin C, Luddy C, Abounader R, Lal B and Laterra J. Glioma inhibition by HGF/NK2, an antagonist of scatter factor/

hepatocyte growth factor. Biochem Biophys Res Comm, 273:287-293, 2000.

Bowers DC, Fan S, Walter K, Abounader R, Williams JA, Rosen EM and Laterra J: Scatter factor/hepatocyte growth factor activates AKT and protects against cytotoxic death in human glioblastoma via PI3-kinase and AKT-dependent pathways. Cancer Res, 60:4277-4283, 2000. [PDF]

Hossain MA, Bouton ML, Pevsner J and Laterra J: Induction of vascular endothelial growth factor in human astrocytes by lead: Involvement of a PKC/AP-1 dependent and HIF-1 independent signaling pathway. J Biol Chem, 275:27874-27882, 2000. [PDF]

Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, Burger P and Laterra J: Reversion of human glioblastoma malignancy by U1snRNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met gene expression. J Natl Cancer Inst, 91:1548-1556, 1999.

Hossain MA, Fielding KE, Trescher WH, Ho T, Wilson MA, and Laterra J. Human FGF-1 gene delivery protects against quinolinate-induced striatal and hippocampal injury in neonatal rats. Eur. J. Neurosci. 10:2490-2499, 1998. [LINK]