Peter Campochiaro - Recent Papers

Lu L, Hackett SF, Mincey A, Lai H, Campochiaro PA (2006).  Effects of different types of oxidative stress in RPE cells.  J Cell Physiol 206:119-125.

Vinores SA, Xiao Wh, Aslam S, Shen J, Oshima Y, Nambu H, Liu H, Carmeliet P, Campochiaro PA (2006). Implication of the hypoxia response element of the vegf promoter in mouse models of retina and choroidal neovascularization, but not retinal vascular development. J Cell Physiol 206: 749-758.

Campochiaro PA, Nguyen QD, Shah SM, Klein ML, Holz E, Frank RN, Saperstein DA, Gupta A, Stout JT, Macko J, DiBartolomeo R, Wei LL (2006). Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Hum Gene Ther 17:167-176.

Shen J, Yang X, Xiao WH, Hackett SF, Sato Y, Campochiaro PA (2006). Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization. FASEB J 20:723-725.

Akiyama H, Kachi S, Lima e Silva, R, Umeda N, Hackett SF, McCauley D, McCauley T, Zoltoski A, Epstein DM, Campochiaro PA (2006). Intraocular injection of an aptamer that binds PDGF-B; a potential treatment for proliferative retinopathies. J Cell Physiol 207:407-412.

Kachi S, Esumi N, Zack DJ, Campochiaro PA (2006). Sustained expression after nonviral ocular gene transfer using mammalian promoters. Gene Ther. 13:798-804.

Cingolani C, Rogers B, Lu L, Kachi S, Shen J, Campochiaro PA (2006). Retinal degeneration from oxidative damage. Free Radic Biol Med.  40:660-669.

Campochiaro PA and the first ARVO/Pfizer Institute Working Group (2006). Ocular versus extraocular neovascularization; mirror images or vague resemblances. Invest Ophthalmol Vis Sci. 47:462-474.

 Lima e Silva R, Kachi S, Akiyama H, Shen J, Aslam S, Yuan Gong Y, Khu NH, Hatara MC, Boutaud A, Peterson R, Campochiaro PA (2006).  Recombinant non-collagenous domain of alpha2(IV) collagen causes involution of choroidal neovascularization by inducing apoptosis.  J Cell Physiol. 208:161-166.

Umeda N, Kachi S, Akiyama H, Zahn G, Vossmeyer D, Stragies R, Campochiaro PA (2006). Suppression and regression of choroidal neovascularization by systemic administration of an a5b1 integrin antagonist. Mol Pharmacol.  69:1820-1828.

Chowers I, Wong R, Dentchey T, Farkas RH, Iacovelli J, Gunatilaka TL, Medeiro NE, Presley JB, Campochiaro PA, Curcio CA, Dunaief JL, Zack D (2006). The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. 47:2135-2140.

Dong A, Shen J, Krause M, Akiyama H, Hackett SF, Lai H, Campochiaro PA (2006). Superoxide dismutase 1 protects retinal cells from oxidative damage. J Cell Physiol 208:516-526.

Komeima K, Rogers B, Lu L, Campochiaro PA (2006). Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci USA103:11300-11305.

Nguyen QD, Shah SM, Hafiz G, Quinlan E, Sung J, Chu K, Cedarbaum JM, Campochiaro PA  and the CLEAR 0305 Study Group (2006). A Phase 1 trial of intravenously administered vascular endothelial growth factor (VEGF) Trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 113:1522.e1-1522.e14.

Lochrie MA, Tatsuno GP, Arbetman AE, Jones K, Pater C, Smith PH, McDonnell  JW, Zhou SZ, Kachi S, Kachi M, Campochiaro PA, Pierce GF, Colosi P(2006). Adeno-associated virus (AAV) capsid genes isolated from rat and mouse liver genomic DNA define two new AAV species distantly related to AAV-5. Virology 353:68-82.

Lima e Silva R, Kachi S, Akiyama H, Shen J, Hatara MC, Aslam S, Gong YY, Khu  NH, Lauer TW, Hackett SF, Marton LJ, Campochiaro PA (2006). Trans-scleral delivery of polyamine analogs for ocular neovascularization. Exp Eye Res 83:1260-7.

Wu Z, Rogers B, Kachi S, Hackett SF, Sick A, Campochiaro PA (2006). Reduction of  p66Shc suppresses oxidative damage in retinal pigmented epithelial cells and retina. J Cell Physiol 209:996-1005.

Shah SM, Tatlipinar S, Quinlan E, Tabandeh H, Nguyen QD, Fahmy AZ, Zimmer-Galler I, Symons RCA, Cedarbaum JM, Campochiaro PA (2006).  Dynamic and quantitative analysis of choroidal neovascularization by fluorescein angiography. Invest Ophthalmol Vis Sci, in press.

Nguyen QD, Tatlipinar S, Shah SM, Haller JA, Quinlan E, Sung J, Zimmer-Galler I, Do DV, Campochiaro PA (2006). Vascular endothelial growth factor is a Critical stimulus for diabetic macular edema. Amer J Ophthalmol, in press.

Pontes de Carvalho RA, Krausee ML, Murphree AL, Schmitt EE, Campochiaro PA, Maumenee IH (2006). Delivery from episcleral exoplants. Invest Ophthalmol Vis Sci 47:4532-4539.

Rogers BS, Symons RCA, Komeima K, Shen J, Xiao W, Swaim ME, Gong YY, Kachi S, Campochiaro PA (2006). Differential sensitivity of cones to iron-mediated oxidative damage. Invest Ophthalmol Vis Sci, in press.

Campochiaro PA (2006). Molecular targets for retinal vascular diseases. J Cell Physiol, in press.

Esumi N, Kachi S, Campochiaro PA, Zack DJ (2006). VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by theMITF-TFE family. J Biol Chem. 2006 Nov 3; [Epub ahead of print].