Philip Wong - Recent Papers

Hu X, Hicks CW, He W, Wong PC, Macklin WB, Trapp BD & Yan R: Bace1 modulates myelination in the central and peripheral nervous system. Nature Neuroscience, online November 12, 2006.

Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee H-K and Wong PC: BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-b Amyloidogenesis is Essential for Cognitive, Emotional and Synaptic Functions.  J. Neuroscience 25:11693–11709, 2005.  [PDF]

Cai H, Lin X, Xie C, Laird FM, Lai C, Wen H, Chiang HC, Shim H, Farah M, Hoke A, Price DL, and Wong PC:  Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knockout mice, but predisposes neurons to oxidative stress.  J. Neuroscience 25:7567–7574, 2005.  [PDF]

Ma G, Li T, Price DL and Wong PC:  Aph-1a is the principal mammalian Aph-1 isoform present in g-secretase complexes during embryonic development.  J. Neuroscience 25:192-198, 2005.  [PDF]

Li T, Ma G, Cai H, Price DL, Wong PC: Nicastrin is required for assembly of presenilin/g-secretase complexes to mediate Notch Signaling, and for processing and trafficking of b-APP in mammals. J. Neuroscience 23: 3272-3277, 2003. [PDF]

Wong PC, Cai H, Borchelt DR and Price DL: Genetically Engineered Mouse Models of Neurodegenerative Diseases. Nature Neuroscience 5:633, 2002. [PDF]

Subramaniam JR, Lyons WE, Liu J, Bartinakas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD and Wong PC: Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nature Neuroscience 5:301, 2002. [PDF]

Wong PC, Price DL, Cai H: The brain's susceptibility to amyloid plaques. Science 293:1434, 2001.

Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL and Wong PC: BACE1 is the major b-secretase for generation of Ab peptides by neurons. Nature Neuroscience 4: 233, 2001.  [PDF]