Johns Hopkins University, Department of Neuroscience
 

 

 

 

Rejji Kuruvilla, PhD


Assistant Professor of Biology and Neuroscience



Telephone Number:  (410) 516 2366
Fax Number:   410-614-1008

Johns Hopkins University

Department of Biology

3400 North Charles Street

Baltimore, MD 21218-2685

Room:  224A Mudd Hall

rkuruvilla@jhu.edu

 

  

 
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Growth factor signal transduction and trafficking in neuronal development

The proper functioning of the nervous system relies on the establishment of precise neuronal circuits. These neuronal circuits are largely formed during early development. To form functional neuronal circuits, neurons receive specific information in the form of extracellular cues from the target tissues that they innervate. The family of neurotrophins provides one of the best examples of these target-derived instructive cues that regulate diverse developmental events in the vertebrate nervous system, including survival, axonal and dendritic growth and synapse formation. Using a combination of cell biological, biochemical and imaging techniques as well as mouse genetics, we are actively pursuing two lines of research; 1. How neurotrophic factors coordinate neuronal development by regulating the neuronal endocytic machinery, and 2. Growth factor signaling pathways underlying axonal growth, morphology and innervation of target tissues during development.




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