Richard O'Brien - Recent Papers

OBrien RJ, Kamboj S, Ehlers MD, D, Rosen KR, Fischbach GD, Huganir RL (1998) Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation. Neuron 21:1067-1078 (See also editorial)

OBrien RJ, Xu D, Petralia R, Huganir RL, Worley P (1999) Synaptic Clustering of AMPA Receptors by the Extracellular Immediate Early Gene Product Narp. Neuron 23: 248-262 (See also editorial) [PDF]

OBrien RJ, Xu D, Mi R, Tang X, Worley P (2002) Synaptically Targeted Narp plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons. J Neuroscience 22: 4487-4498 [PDF]

Mi R, Tang X, Sutter R, Xu D, Worley P and OBrien RJ (2002) Differing Mechanisms for Glutamate Receptor Clustering on Dendritic Spines and Shafts in Cultured Hippocampal Neurons. J Neuroscience 22: 7606-7616 [PDF]

Xu D, Hopf C, Reddy R, Cho RW, Guo L, Lanahan A, Petralia RS, Wenthold RJ, O'Brien RJ, Worley P (2003) Narp and NP1 Form Heterocomplexes that Function in Developmental and Activity-Dependent Synaptic Plasticity. Neuron. 39(3):513-28.

Mi R , Sia GM , Tang X , Moghekar A, Huganir RL, and OBrien RJ (2004) AMPA Receptor Dependent Coclustering of Synaptic NMDA Receptors in Spinal Neurons and Hippocampal Interneuons is Dependent on Stargazin and NR2A/B. Neuron 44: 335-349

Gamaldo A Resnick S Kilada S Troncoso J  Zonderman A  OBrien RJ (2006) The Interaction between Stroke and Alzheimer Pathology on Dementia in the Baltimore Longitudinal Study of Aging. Neurology 67: 1363-1369 (See Editorial)

Driscoll I, Resnick SM, Troncoso JC, An Y, O’Brien RJ, Zonderman AB (2006) Impact of Alzheimer pathology on cognitive trajectories in non-demented elderly. Annals of Neurology 60:688-695 (See Editorial)

Rosen K, Moghekar A and OBrien RJ (2007) Activity Dependent Localization of Synaptic NMDA Receptors in Spinal Neurons. Molecular and Cellular Neuroscience 34:578-91

Troncoso  J, Zonderman A, Resnick S, Kraut M, Pletnikova O,  and OBrien R. The Effect of Stroke and Alzheimer Pathology on the Risk of Dementia in the Baltimore Longitudinal Study of Aging Autopsy Program. Annals of Neurology (In Press)