Ted Dawson - Recent Papers

Nucifora, F.C. Jr., M. Sasaki, M. F. Peters, H. Huang, J.K. Cooper, M. Yamada, H. Takahashi, H. Tsuji, J. Troncoso, V. L. Dawson, T.M. Dawson*, and C. A. Ross*. "Interference by Huntingtin and Atrophin-1 CBP-Mediated Transcription Leading to Cellular Toxicity." Science, 291: 2423-2428 (2001). [PDF]

Chung, K.K.K, Y. Zhang, K. L. Lim, Y. Tanaka, H. Huang, J. Gao, C. A. Ross, V. L. Dawson and T. M. Dawson. "Parkin Ubiquitinates the a-Synuclein-Interacting Protein, Synphilin-1: Implications for Lewy Body Formation in Parkinson Disease." Nature Medicine, 7:1144-1150 (2001). [PDF]

Lee, M.K., W. Stirling, Y. Xu, X, Xu, D. Qui, A.S. Mandir, T.M. Dawson, N.G. Copeland, N.A Jenkins, D.L. Price. “Human a-Synuclein Harboring Familial Parkinson’s Disease Linked Ala53Thr Mutation Causes Neurodegenerative Disease with a-Synuclein Aggregation in Transgenic Mice.” Proc. Natl. Acad. Sci. U.S.A., 99: 8968-8973 (2002). [PDF]

Dawson, T.M. and V.L. Dawson. “Neuroprotective and Neurorestorative Strategies for Parkinson’s Disease.” Nature Neuroscience, 5:1058-1061 (2002). [PDF]

Yu, S.-W., H.-M. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, Guy G. Poirer, T.M. Dawson, V.L. Dawson “Mediation of PARP-1 Mediated Cell Death by Apoptosis Inducing Factor.” Science, 297: 259-263 (2002).

Dawson, T.M., A.S. Mandir and M.K. Lee, “Animal Models of PD; Pieces of the Same Puzzle.” Neuron, 35: 219-222 (2002). Dawson, T.M. and V.L. Dawson. “Molecular Pathways of Neurodegeneration in Parkinson’s Disease” Science, 302: 219-222 (2003). [PDF]

Li, H., X. Gu, V.L. Dawson and T.M. Dawson. “Identification of Calcium and Nitric Oxide Regulated Genes by Differential Analysis of Library Expression (DAzLE). Proc. Natl. Acad. Sci. U.S.A., 101: 647-652 (2004). [PDF]

Hong, S.J., H. Li, K.G. Becker, V.L. Dawson*, and T.M. Dawson*. “Identification and Analysis of Plasticity-Induced Late Response Genes.” Proc. Natl. Acad. Sci. U.S.A., 101:2145-2150 (2004). [PDF]

Chung, K.K.K., B. Thomas, X. Li, O. Pletnikova, J.C. Troncoso, L. Marsh, V. L. Dawson and T.M. Dawson. “S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin’s Protective Function.” Science, 304:1328-1331 (2004). [PDF]

Hong, S.J., T.M. Dawson and V.L. Dawson. “Nuclear and Mitochondrial Conversations in Cell Death: PARP-1 and AIF Signaling.” Trends in Pharmacological Sciences, 25: 259-264 (2004). [PDF]

Von Coelln, R., B. Thomas, J. M. Savitt, K.L. Lim, M. Sasaki, E. Hess, V.L. Dawson, T.M. Dawson. “Loss of Locus Coeruleus Neurons and Reduced Startle in Parkin Null Mice” Proc. Natl. Acad. Sci. U.S.A.,101(29) 10744-10749 (2004). [PDF]

****Yu, S.-W., H.-M. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, Guy G. Poirer, T.M. Dawson, V.L. Dawson “Mediation of PARP-1 Mediated Cell Death by Apoptosis Inducing Factor.” Science, 297: 259-263 (2002).  [PDF]

Hong, S.J., H. Li, K.G. Becker, V.L. Dawson, and T.M. Dawson. “Identification and Analysis of Plasticity-Induced Late Response Genes.” Proc. Natl. Acad. Sci. U.S.A., 101:2145-2150 (2004).  [PDF]

Chung, K.K.K., B. Thomas, X. Li, O. Pletnikova, J.C. Troncoso, L. Marsh, V. L. Dawson and T.M. Dawson. “S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin’s Protective Function.” Science, 304:1328-1331 (2004).  [PDF]

Koh, D.W., A.M. Lawler, M.F. Poitras*, M. Sasaki, S. Wattler, M.C. Nehls, T. Stöger, G.G. Poirier, V.L. Dawson, T.M. Dawson.  “Failure to Degrade Poly(ADP-ribose) Causes Increased Sensitivity to Cytotoxicity and Early Embryonic Lethality” Proc. Natl. Acad. Sci. U.S.A., 101:17699-17704 (2004).  [PDF]

Moore, D.J., A.B. West, V.L. Dawson and T.M. Dawson. “Molecular Pathophysiology of Parkinson’s Disease.”  Annual Review of Neuroscience, 28: 55-84 (2005).  [PDF]

West, A., D. Moore, A. Bugayenko, S. Biskup, W.W. Smith, C.A. Ross, V. L. Dawson and T.M. Dawson. “ Parkinson’s Disease Associated Mutations in Leucine Rich Repeat Kinase 2 Augment Kinase Activity.” Proc. Natl. Acad. Sci. U.S.A., 102:16842-16847 (2005).   [PDF]

Riccio, A., R.S. Alvania, B.E. Lonze, N. Ramanan, T. Kim, Y. Huang, T.M. Dawson, S.H. Synder and D.D. Ginty. “A Nitric Oxide Signalling Pathway Controls CREB-mediated Gene Expression in Neurons.” Molecular Cell, 21:283-294 (2006).   [PDF]

Smith, W.W. Z. Pei, H. Jiang, V. L. Dawson, T.M. Dawson, C.A. Ross.  “Kinase Activity of Mutant LRRK2 Mediates Neuronal Toxicity.”  Nature Neuroscience, 9:1231-3. Epub 2006 Sep 17. (2006). PMID: 16980962  [PDF]

Andrabi, S., N.S. Kim, S.W. Yu, H. Wang, D. Koh, M. Sasaki, J.A. Klaus, T. Otsuka, Z. Zhang, R.C. Koehler, P. Hurn, G.G. Poirier, V.L. Dawson* and T.M. Dawson*. “Poly (ADP-ribose) (PAR) Polymer is a Death Signal.” Proc. Natl. Acad. Sci. U.S.A. [Epub Nov. 20, 2006, 10.1073/pnas.0606526103] 103: 18308–18313  (2006). *Co-Senior and Corresponding Authors.  [PDF]

Yu, S.W., S.A. Andrabi, H. Wang, N.S. Kim, G.G. Poirier, T.M. Dawson and V.L. Dawson. “Apoptosis Inducing Factor (AIF) Mediates Poly (ADP-ribose) (PAR) Polymer Induced Cell Death” .”  Proc. Natl. Acad. Sci. U.S.A. [Epub Nov. 20, 2006, 10.1073/pnas.0606528103] 103: 18314–18319 (2006).  [PDF]

Andres-Mateos, E., C. Perier, L. Zhang, B. Blanchard-Fillion, T.M. Greco, B. Thomas, H.S. Ko, M. Sasaki, H. Ischiropoulos, S. Przedborski, T.M. Dawson and V.L. Dawson.  “DJ-1 Deletion Reveals that DJ-1 is an Atypical Peroxiredoxin-like Peroxidase.” Proc. Natl. Acad. Sci. U.S.A., 104:14807–14812 (2007).