Figure 1. Apoptosis Inducing Factor Translocates to the Nucleus in Wild-type Neurons After Exposure to Neurotoxic NMDA but does not Translocate in PARP-1 Knockout Neurons. PARP-1 triggers AIF release from mitochondria that results in nuclear condensation, DNA cleavage and neuronal cell death.
© 2005 Department of Neuroscience, Johns Hopkins University School of Medicine