
Lishi Li, Michael Rutlin, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, H. Richard Koerber, C. Jeffery Woodbury, David D. Ginty. (2011). The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons. Cell, 147, 1615-27.
Molecular genetics are here used to label and visualize mechanosensory neurons that mediate touch perception at hair follicles in the skin. Each distinct class of hair follicle is innervated by a unique combination of mechanosensory neurons, making each type of hair follicle a functionally distinct mechanosensor. The image illustrates the complex pattern of mechanosensory neuron axon terminals encircling a guard hair follicle of a neuropeptide Y2 receptor-GFP (Npy2r-GFP) transgenic mouse. Nerve terminals expressing neurofilament 200 (NF200) are purple, whereas those expressing Npy2r-GFP are green. Double-positive fibers are white.