Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for schizophrenia and other major mental disorders, regulates neuronal migration, differentiation, and neurogenesis in the mammalian brain. A recent study from Dr. Guo-li Ming ‘s laboratory identifies important roles for KIAA1212/Girdin in mediating crosstalk between DISC1 and the AKT-mTOR signaling pathway. The cover illustration in Neuron ( Volume  6, issue 3 , 2009) depicts two discs, one of newborn neurons with over-elaborated growth with DISC1 suppression (upper ring) and the other with rescue of these developmental defects by inhibition of AKT-mTOR signaling (lower ring).   Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL.  DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.  Neuron. 2009 Sep 24;63(6):761-73.