For all the latest news from the Solomon H. Snyder Department of Neuroscience

  • Fri 17th February 2017

    Publications - March 2017

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  • Fri 17th February 2017

    Publications - February 2017

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  • Thu 16th February 2017

    New Research Investigating Cellular Basis of Memory from Knierim Lab Appears in Neuron

    The hippocampus is a brain area involved in learning and memory.  The dentate gyrus, a subregion of the hippocampus, may prevent interference between similar memories, but it is unclear how the two main dentate gyrus cell types, granule cells and mossy cells, contribute to this process.  GoodSmith et al. recorded from granule cells and mossy cells as rats explored distinct environments.  Different groups of granule cells fired in different environments, but mossy cells fired in multiple locations in most environments, a feature previously attributed to granule cells. This study resolves a longstanding debate about the firing properties of granule cells, shows that mossy cells have spatial firing, and describes distinct ways in which granule cells and mossy cells can contribute to the ability to distinguish between environments.

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  • Tue 7th February 2017

    New study by Huganir Lab in Science reveals synapse dynamics during sleep

    Sleep is an essential process that plays a critical role in supporting cognitive functions such as learning and memory consolidation. Synapses in the brain are the structures responsible for forming and maintaining memories. Studying mice, we found that synapses become stronger while the mice were awake and weaker during sleep by removal of the neurotransmitter receptors called AMPA receptors. This is a process called homeostatic scaling-down. Scaling-down during sleep was driven by a protein called Homer1a which builds up in neurons while the mice were awake but is prevented from accessing the synapses until sleep, by the arousal promoting neuromodulator noradrenaline. In this way, the scaling of synapses is limited while awake and engaged as we transition to sleep. Homer1a targeting to synapses was also observed during sleep deprivation, activated by the sleep promoting neuromodulator adenosine. Sleep is well known to enhance memory consolidation whereas sleep deprivation greatly impairs memory formation. Our study suggests that weakening of synapses during sleep contributes to learning and memory, and that if this process is engaged during sleep deprivation memories become lost.

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  • Mon 6th February 2017

    Publications - January 2017

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  • Mon 6th February 2017

    Publications - December 2016

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  • Wed 4th January 2017

    Blackshaw Lab identifies link between master clock and control of sleep and body temperature.

    A clump of just a few thousand brain cells, no bigger than a mustard seed, controls the daily ebb and flow of most bodily processes in mammals -- sleep/wake cycles, most notably. Now, Johns Hopkins scientists report direct evidence in mice for how those cell clusters control sleep and relay light cues about night and day throughout the body.

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  • Sat 1st October 2016

    Publications - October 2016

    Publications from Primary Faculty Members - October 2016: Finley, JM, Bastian, AJ.  Associations Between Foot Placement Asymmetries and Metabolic Cost of Transport in Hemiparetic Gait. Neuroehabil Neural Repair.  2016 Oct 20. pii: 1545968316675428. [Epub ahead of print]   Corbit, LH, Janak, PH. Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training. Front Psychiatry. 2016 Oct 10;7:169. eCollection 2016.   Gu, Y, Huganir, ...

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  • Thu 1st September 2016

    Publications - September 2016

    Publications from Primary Faculty Members - September 2016 Gillary G, Niebur E. The Edge of Stability: Response Times and Delta Oscillations in Balanced Networks. PLoS Comput Biol. 2016 Sep 30;12(9):e1005121. doi: 10.1371/journal.pcbi.1005121. eCollection 2016.   Roemmich RT, Long AW, Bastian AJ.  Seeing the Errors You Feel Enhances Locomotor Performance but Not Learning.Curr Biol. 2016 Sep 15. pii: S0960-9822(16)30924-1. doi: 10.1016/j.cub.2016.08.012. [Epub ahead of prin...

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  • Mon 29th August 2016

    Foster lab reports in Neuron how rats form memories associated with food rewards.

    The Brain Uses Backward Instant Replays to Remember Important Travel Routes

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  • Mon 1st August 2016

    Publications - August 2016

    Publications from Primary Faculty Members - August 2016 Diering GH, Heo S, Hussain NK, Liu B, Huganir RL. Extensive phosphorylation of AMPA receptors in neurons. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4920-7. doi: 10.1073/pnas.1610631113. Epub 2016 Aug 1.  Jin Y, Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ. Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury. Neuron. 2016 Aug 17;91(4):748-62. doi:...

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  • Fri 1st July 2016

    Publications - July 2016

    Publications from Primary Faculty Members - July 2016 Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites. Neuron. 2016 Jul 5. pii: S0896-6273(16)30294-X. doi: 10.1016/j.neuron.2016.06.017. [Epub ahead of print] Wagatsuma N, von der Heydt R, Niebur E. Spike Synchrony Generated by Modulatory Common Input through NMDA-type Synapses. J Neurophysiol. 2016 J...

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  • Thu 2nd June 2016

    Wu lab identifies neural circuits underlying sleep drive in flies

    'You Are Getting Sleepy,' Said The Scientist To The Fruit Fly

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  • Wed 1st June 2016

    Publications - June 2016

    Publications from Primary Faculty Members - June 2016 Hart, RP, Goff, LA. Long Noncoding RNAs: Central to Nervous System Development. Int J Dev Neurosci. 2016 Jun 10. pii: S0736-5748(16)30109-5. doi: 10.1016/j.ijdevneu.2016.06.001. [Epub ahead of print] Gomez-Ramirez M, Hysaj K, Niebur E. Neural mechanisms of selective attention in the somatosensory system. J Neurophysiol. 2016 Jun 22:jn.00637.2015. doi: 10.1152/jn.00637.2015. [Epub ahead of print] Lin CC, Potter CJ. Editi...

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  • Tue 24th May 2016

    Publications - April 2016

    Publications from Primary Faculty Members - April 2016 Evsen L, Doetzlhofer A. Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation. J Vis Exp. 2016 Apr 17;(110). doi: 10.3791/53864. Fu X, Shah A, Baraban JM. Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity. Neurobiol Learn Mem. 2016 Apr 20. pii: S1074-7427(16)30028-4. doi: 10.1016/j.nlm.2016.04.006. [Epub ahead of print] Musselman KE,...

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  • Thu 31st March 2016

    Publications - March 2016

    Publications from Primary Faculty Members - March 2016 Corbit LH, Fischbach SC, Janak PH. Nucleus Accumbens Core and Shell are Differentially Involved in General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer with Alcohol and Sucrose Rewards. Eur J Neurosci. 2016 Mar 11. doi: 10.1111/ejn.13235. [Epub ahead of print]   Harraz MM, Tyagi R, Cortés P, Snyder SH. Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradat...

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  • Mon 29th February 2016

    Publications - February 2016

    Publications from Primary Faculty Members - February 2016 de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405. doi: 10.1523/JNEUROSCI.3145-15.2016. Gu Y, Chiu SL, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D, Huganir RL. Differential vesicular sorting of AMPA and GABAA receptors.Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.107...

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  • Sun 31st January 2016

    Publications - January 2016

    Publications from Primary Faculty Members - January 2016 Campbell DP, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016 Jan 20;6:19484. doi: 10.1038/srep19484. Kim J, Matney CJ, Roth RH, Brown SP. Synaptic Organization of the Neuronal Circuits of the Claustrum. J Neurosci. 2016 Jan 20;36(3):773-84. doi: 10.1523/JNEUROSCI.3643-15.2016. Therrien AS, Wolpert DM, Bastian AJ. Effective ...

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  • Thu 31st December 2015

    Publications - December 2015

    Publications from Primary Faculty Members - December 2015 Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J Neurosci. 2015 Dec 2;35(48):15916-20. doi: 10.1523/JNEUROSCI.1813-15.2015. Silva, D, Feng, T, Foster, DJ. Trajectory events across hippocampal place cells require previous experience. Nat Neurosci. 2015 Dec;18(12):1772-9. doi: 10.1038/nn.4151. Epub 2015 Oct 26. Vazquez A, Statton MA, Busgang ...

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  • Mon 30th November 2015

    Publications - November 2015

    Publications from Primary Faculty Members - November 2015 Chen X, Stuphorn V. Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions. Elife. 2015 Nov 27;4. pii: e09418. doi: 10.7554/eLife.09418. He K, Huertas M, Hong SZ, Tie 1, Hell JW, Shouval H, Kirkwood A. Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron. 2015 Nov 4;88(3):528-38. doi: 10.1016/j.neuron.2015.09.037. Epub 2015 Oct 22. Rober...

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  • Sat 31st October 2015

    Publications - October 2015

    Publications from Primary Faculty Members - October 2015 Hussain NK, Thomas GM, Luo J, Huganir RL. Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5883-90. doi: 10.1073/pnas.1518382112. Epub 2015 Oct 12. Lin CC, Potter CJ. Re-Classification of Drosophila melanogaster Trichoid and Intermediate Sensilla Using Fluorescence-Guided Single Sensillum Recording. PLoS One. 2015 Oct 2;10(10):e0139675...

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  • Wed 30th September 2015

    Publications - September 2015

    Publications from Primary Faculty Members - September 2015 Bedont JL, Newman EA, Blackshaw S. Patterning, specification, and differentiation in the developing hypothalamus. Wiley Interdiscip Rev Dev Biol. 2015 Sep;4(5):445-68. doi: 10.1002/wdev.187. Epub 2015 Mar 27. Larson, VA, Zhang, Y, Bergles, DE. Electrophysiological properties of NG2+ cells: Matching physiological studies with gene expression profiles. Brain Res. 2015 Sep 15. pii: S0006-8993(15)00708-8. doi: 10.1016/j...

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  • Mon 31st August 2015

    Publications - August 2015

    Publications from Primary Faculty Members - August 2015 Ahmed I, Sbodio JI, Harraz MM, Tyagi R, Grima JC, Albacarys LK, Hubbi ME, Xu R, Kim S, Paul BD, Snyder SH. Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9751-6. doi: 10.1073/pnas.1511810112. Epub 2015 Jul 20. Fu C, Xu J, Li RJ, Crawford JA, Khan AB, Ma TM, Cha JY, Snowman AM, Pletnikov MV, Snyder SH. Inositol Hexakisphosphate Kinase-3 Regu...

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  • Thu 30th July 2015

    Publications - July 2015

    Publications from Primary Faculty Members - July 2015   Golden EJ, Benito-Gonzalez A, Doetzlhofer A. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73. doi: 10.1073/pnas.1501077112. Epub 2015 Jul 2. Hand, RA. Khalid, S, Tam, E, Kolodkin, AL. Axon Dynamics during Neocortical Laminar Innervation. Cell Rep. 2015 Jul 14;12(2):172-82. doi: 10.1016/j.celrep.2015.06.026. Epub 2015 Ju...

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  • Wed 17th June 2015

    Publications - June 2015

    Publications from Primary Faculty Members - June 2015 Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, Lee HK. Vision Loss Shifts the Balance of Feedforward and Intracortical Circuits in Opposite Directions in Mouse Primary Auditory and Visual Cortices. J Neurosci. 2015 Jun 10;35(3)8790-801. doi: 10.1523/JNEUROSCI.4975-14.2015. View on Pubmed...

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