Mon 20th March 2017
Publications- April 2017
Thu 2nd March 2017
Bergles Lab work featured on cover of Neuron
In a recent issue of Neuron, Agarwal et al. (2017) report that calcium efflux from mitochondria during brief openings of the mitochondrial permeability transition pore (mPTP) contribute to calcium microdomains.
Thu 23rd February 2017
Xinzhong Dong's lab reports in the current issue of Neuron how itch-detecting neurons manage pain
It is a puzzle that troubles the field for many years that how pain and itch, two closely related sensations (once thought as one sensation), are differentiated by the nervous systems. Coding of pain and itch are heatedly debated for decades. The current specificity theory suggests that these two kinds of signals are carried by separate pathways, with some interactions, for example pain can inhibit itch and that explains why we all scratch to inhibit pain. It is true in the periphery (our previous study indicate a small population of neurons in the periphery only codes for itch sensation), but a study from our lab suggests that there could be more crosstalk between these two sensations in the central than we expected. People might not notice in real life, but in human psychophysical studies, well-isolated experimental environments, when human subjects are given itchy substances, they typically report intense itch sensations accompanied by minor noxious sensations, such as pricking, stinging and burning. Our new leaky gate model suggest in certain circumstances intense itch signals can trigger minor pain sensations, which can explain such phenomenon.
Wed 22nd February 2017
Xinzhong Dong's Lab reports in the current issue of PNAS about the role of MRGPRX1 in persistent pain
Chronic pain is a major health and economic problem worldwide with an estimated prevalence reaching epidemic levels of >25% of the population. For example in the US, chronic pain affects over 116 million adults and costs up to $635 billion annually in treatment and lost productivity. Most drugs on the market for chronic pain have undesired side effects because their targets exist both inside and outside the pain pathways. MrgprX1, a human GPCR, is a promising target of novel pain inhibitors, mainly because of its restricted expression in pain-sensing neurons. Many pharmaceutical companies have conducted drug screens to target human MrgprX1. However, constrained by species differences across Mrgprs, many drug candidates activate MrgprX1 but not the rodent orthologues, leaving no animal model responsive to test the effect on pain in vivo. To overcome the species specificity problem, Xinzhong Dong's lab generated a transgenic mouse line in which they replaced mouse Mrgprs with human MrgprX1. This valuable humanized mouse allowed them to characterize a potent positive allosteric modulator of MrgprX1, ML382. Cellular studies in humanized MrgprX1 mice suggest that ML382 enhances the ability of MrgprX1 to inhibit N-type Ca2+ channels via the Gi pathway in nociceptive neurons and block presynaptic terminal transmission in spinal cord. Importantly, ML382 effectively attenuates evoked persistent and spontaneous pain without causing peripheral or central side effects such as itch, motor dysfunction, or reward in the naïve condition. The group's findings suggest that humanized MrgprX1 mice provide an essential preclinical model and that activating MRGPRX1 is an effective way to treat persistent pain.
Fri 17th February 2017
Publications - March 2017
Publications from Primary Faculty Members - March 2017:
Chiu SL, Diering GH, Ye B, Takamiya K, Chen CM, Jiang Y, Niranjan T, Schwartz CE, Wang T, Huganir RL. GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron. 2017 Mar 8. pii: S0896-6273(17)30139-3. doi: 10.1016/j.neuron.2017.02.031. [Epub ahead of print]
Cox E, Hwang W, Uzoma I, Hu J, Guzzo C, Jeong J, Matunis M, Qian J, Zhu H, Blackshaw S. Global analysis of SUMO-binding proteins identifies SUMOylation as a key regulator of the INO80 chromatin remodeling complex. Mol Cell Proteomics. 2017 Mar 2. pii: mcp.M116.063719. doi: 10.1074/mcp.M116.063719. [Epub ahead of print]
Gao M, Whitt JL, Huang S, Lee A, Mihalas S, Kirkwood A, Lee HK. Experience-dependent homeostasis of 'noise' at inhibitory synapses preserves information coding in adult visual cortex. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715). pii: 20160156. doi: 10.1098/rstb.2016.0156.
Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21.
Fri 17th February 2017
Publications - February 2017
Publications from Primary Faculty Members - February 2017:
Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 8;93(3):587-605.e7. doi: 10.1016/j.neuron.2016.12.034. Epub 2017 Jan 26.
Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017 Feb 3;355(6324):511-515. doi: 10.1126/science.aai8355. Epub 2017 Feb 2.
Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Harraz MM, Snyder SH. Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase. Proc Natl Acad Sci U S A. 2017 Feb 2. pii: 201700165. doi: 10.1073/pnas.1700165114. [Epub ahead of print]
GoodSmith D, Chen X, Wang C, Kim SH, Song H, Burgalossi A, Christian KM, Knierim JJ. Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus. Neuron. 2017 Feb 8;93(3):677-690.e5. doi: 10.1016/j.neuron.2016.12.026. Epub 2017 Jan 26.
Smith-Hicks CL, Cai P, Savonenko AV, Reeves RH, Worley PF. Increased Sparsity of Hippocampal CA1 Neuronal Ensembles in a Mouse Model of Down Syndrome. Front Neural Circuits. 2017 Feb 3;11:6. doi: 10.3389/fncir.2017.00006. eCollection 2017.
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Neuron. 2017 Feb 22;93(4):840-853.e5. doi: 10.1016/j.neuron.2017.01.012.
Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. Elife. 2017 Feb 10;6. pii: e18492. doi: 10.7554/eLife.18492.
Thu 16th February 2017
New Research Investigating Cellular Basis of Memory from Knierim Lab Appears in Neuron
The hippocampus is a brain area involved in learning and memory. The dentate gyrus, a subregion of the hippocampus, may prevent interference between similar memories, but it is unclear how the two main dentate gyrus cell types, granule cells and mossy cells, contribute to this process. GoodSmith et al. recorded from granule cells and mossy cells as rats explored distinct environments. Different groups of granule cells fired in different environments, but mossy cells fired in multiple locations in most environments, a feature previously attributed to granule cells. This study resolves a longstanding debate about the firing properties of granule cells, shows that mossy cells have spatial firing, and describes distinct ways in which granule cells and mossy cells can contribute to the ability to distinguish between environments.
Tue 7th February 2017
New study by Huganir Lab in Science reveals synapse dynamics during sleep
Sleep is an essential process that plays a critical role in supporting cognitive functions such as learning and memory consolidation. Synapses in the brain are the structures responsible for forming and maintaining memories. Studying mice, we found that synapses become stronger while the mice were awake and weaker during sleep by removal of the neurotransmitter receptors called AMPA receptors. This is a process called homeostatic scaling-down. Scaling-down during sleep was driven by a protein called Homer1a which builds up in neurons while the mice were awake but is prevented from accessing the synapses until sleep, by the arousal promoting neuromodulator noradrenaline. In this way, the scaling of synapses is limited while awake and engaged as we transition to sleep. Homer1a targeting to synapses was also observed during sleep deprivation, activated by the sleep promoting neuromodulator adenosine. Sleep is well known to enhance memory consolidation whereas sleep deprivation greatly impairs memory formation. Our study suggests that weakening of synapses during sleep contributes to learning and memory, and that if this process is engaged during sleep deprivation memories become lost.
Mon 6th February 2017
Publications - January 2017
Publications from Primary Faculty Members - January 2017:
Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, Sockanathan S. GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener. 2017 Jan 19;12(1):8. doi: 10.1186/s13024-017-0148-1.
Lagerlöf O, Hart GW, Huganir RL. O-GlcNAc transferase regulates excitatory synapse maturity. Proc Natl Acad Sci U S A. 2017 Jan 31. pii: 201621367. doi: 10.1073/pnas.1621367114. [Epub ahead of print]
Savelli F, Luck JD, Knierim JJ. Framing of grid cells within and beyond navigation boundaries. Elife. 2017 Jan 13;6. pii: e21354. doi: 10.7554/eLife.21354. [Epub ahead of print]
Mon 6th February 2017
Publications - December 2016
Publications from Primary Faculty Members - December 2016:
Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S. An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr Biol. 2017 Jan 9;27(1):128-136. doi: 10.1016/j.cub.2016.11.008. Epub 2016 Dec 22.
Cave, C, Sockanathan, S. Transcription Factor Hand-offs "Enhance" Motor Neuron Differentiation. Neuron. 2016 Dec 21;92(6):1149-1151. doi: 10.1016/j.neuron.2016.12.009.
Williford JR, von der Heydt R. Figure-Ground Organization in Visual Cortex for Natural Scenes. eNeuro. 2016 Dec 29;3(6). pii: ENEURO.0127-16.2016. doi: 10.1523/ENEURO.0127-16.2016.
Wed 4th January 2017
Blackshaw Lab identifies link between master clock and control of sleep and body temperature.
A clump of just a few thousand brain cells, no bigger than a mustard seed, controls the daily ebb and flow of most bodily processes in mammals -- sleep/wake cycles, most notably. Now, Johns Hopkins scientists report direct evidence in mice for how those cell clusters control sleep and relay light cues about night and day throughout the body.
Sat 1st October 2016
Publications - October 2016
Publications from Primary Faculty Members - October 2016:
Finley, JM, Bastian, AJ. Associations Between Foot Placement Asymmetries and Metabolic Cost of Transport in Hemiparetic Gait. Neuroehabil Neural Repair. 2016 Oct 20. pii: 1545968316675428. [Epub ahead of print]
Corbit, LH, Janak, PH. Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training. Front Psychiatry. 2016 Oct 10;7:169. eCollection 2016.
Gu, Y, Huganir, ...
Thu 1st September 2016
Publications - September 2016
Publications from Primary Faculty Members - September 2016
Gillary G, Niebur E. The Edge of Stability: Response Times and Delta Oscillations in Balanced Networks. PLoS Comput Biol. 2016 Sep 30;12(9):e1005121. doi: 10.1371/journal.pcbi.1005121. eCollection 2016.
Roemmich RT, Long AW, Bastian AJ. Seeing the Errors You Feel Enhances Locomotor Performance but Not Learning.Curr Biol. 2016 Sep 15. pii: S0960-9822(16)30924-1. doi: 10.1016/j.cub.2016.08.012. [Epub ahead of prin...
Mon 29th August 2016
Foster lab reports in Neuron how rats form memories associated with food rewards.
The Brain Uses Backward Instant Replays to Remember Important Travel Routes
Mon 1st August 2016
Publications - August 2016
Publications from Primary Faculty Members - August 2016
Diering GH, Heo S, Hussain NK, Liu B, Huganir RL. Extensive phosphorylation of AMPA receptors in neurons. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4920-7. doi: 10.1073/pnas.1610631113. Epub 2016 Aug 1.
Jin Y, Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ. Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury. Neuron. 2016 Aug 17;91(4):748-62. doi:...
Fri 1st July 2016
Publications - July 2016
Publications from Primary Faculty Members - July 2016
Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites. Neuron. 2016 Jul 5. pii: S0896-6273(16)30294-X. doi: 10.1016/j.neuron.2016.06.017. [Epub ahead of print]
Wagatsuma N, von der Heydt R, Niebur E. Spike Synchrony Generated by Modulatory Common Input through NMDA-type Synapses. J Neurophysiol. 2016 J...
Thu 2nd June 2016
Wu lab identifies neural circuits underlying sleep drive in flies
'You Are Getting Sleepy,' Said The Scientist To The Fruit Fly
Wed 1st June 2016
Publications - June 2016
Publications from Primary Faculty Members - June 2016
Hart, RP, Goff, LA. Long Noncoding RNAs: Central to Nervous System Development. Int J Dev Neurosci. 2016 Jun 10. pii: S0736-5748(16)30109-5. doi: 10.1016/j.ijdevneu.2016.06.001. [Epub ahead of print]
Gomez-Ramirez M, Hysaj K, Niebur E. Neural mechanisms of selective attention in the somatosensory system. J Neurophysiol. 2016 Jun 22:jn.00637.2015. doi: 10.1152/jn.00637.2015. [Epub ahead of print]
Lin CC, Potter CJ. Editi...
Tue 24th May 2016
Publications - April 2016
Publications from Primary Faculty Members - April 2016
Evsen L, Doetzlhofer A. Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation. J Vis Exp. 2016 Apr 17;(110). doi: 10.3791/53864.
Fu X, Shah A, Baraban JM. Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity. Neurobiol Learn Mem. 2016 Apr 20. pii: S1074-7427(16)30028-4. doi: 10.1016/j.nlm.2016.04.006. [Epub ahead of print]
Thu 31st March 2016
Publications - March 2016
Publications from Primary Faculty Members - March 2016
Corbit LH, Fischbach SC, Janak PH. Nucleus Accumbens Core and Shell are Differentially Involved in General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer with Alcohol and Sucrose Rewards. Eur J Neurosci. 2016 Mar 11. doi: 10.1111/ejn.13235. [Epub ahead of print]
Harraz MM, Tyagi R, Cortés P, Snyder SH. Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradat...
Mon 29th February 2016
Publications - February 2016
Publications from Primary Faculty Members - February 2016
de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405. doi: 10.1523/JNEUROSCI.3145-15.2016.
Gu Y, Chiu SL, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D, Huganir RL. Differential vesicular sorting of AMPA and GABAA receptors.Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.107...
Sun 31st January 2016
Publications - January 2016
Publications from Primary Faculty Members - January 2016
Campbell DP, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016 Jan 20;6:19484. doi: 10.1038/srep19484.
Kim J, Matney CJ, Roth RH, Brown SP. Synaptic Organization of the Neuronal Circuits of the Claustrum. J Neurosci. 2016 Jan 20;36(3):773-84. doi: 10.1523/JNEUROSCI.3643-15.2016.
Therrien AS, Wolpert DM, Bastian AJ. Effective ...
Thu 31st December 2015
Publications - December 2015
Publications from Primary Faculty Members - December 2015
Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J Neurosci. 2015 Dec 2;35(48):15916-20. doi: 10.1523/JNEUROSCI.1813-15.2015.
Silva, D, Feng, T, Foster, DJ. Trajectory events across hippocampal place cells require previous experience. Nat Neurosci. 2015 Dec;18(12):1772-9. doi: 10.1038/nn.4151. Epub 2015 Oct 26.
Vazquez A, Statton MA, Busgang ...
Mon 30th November 2015
Publications - November 2015
Publications from Primary Faculty Members - November 2015
Chen X, Stuphorn V. Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions. Elife. 2015 Nov 27;4. pii: e09418. doi: 10.7554/eLife.09418.
He K, Huertas M, Hong SZ, Tie 1, Hell JW, Shouval H, Kirkwood A. Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron. 2015 Nov 4;88(3):528-38. doi: 10.1016/j.neuron.2015.09.037. Epub 2015 Oct 22.
Sat 31st October 2015
Publications - October 2015
Publications from Primary Faculty Members - October 2015
Hussain NK, Thomas GM, Luo J, Huganir RL. Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5883-90. doi: 10.1073/pnas.1518382112. Epub 2015 Oct 12.
Lin CC, Potter CJ. Re-Classification of Drosophila melanogaster Trichoid and Intermediate Sensilla Using Fluorescence-Guided Single Sensillum Recording. PLoS One. 2015 Oct 2;10(10):e0139675...
Wed 30th September 2015
Publications - September 2015
Publications from Primary Faculty Members - September 2015
Bedont JL, Newman EA, Blackshaw S. Patterning, specification, and differentiation in the developing hypothalamus. Wiley Interdiscip Rev Dev Biol. 2015 Sep;4(5):445-68. doi: 10.1002/wdev.187. Epub 2015 Mar 27.
Larson, VA, Zhang, Y, Bergles, DE. Electrophysiological properties of NG2+ cells: Matching physiological studies with gene expression profiles. Brain Res. 2015 Sep 15. pii: S0006-8993(15)00708-8. doi: 10.1016/j...
Mon 31st August 2015
Publications - August 2015
Publications from Primary Faculty Members - August 2015
Ahmed I, Sbodio JI, Harraz MM, Tyagi R, Grima JC, Albacarys LK, Hubbi ME, Xu R, Kim S, Paul BD, Snyder SH. Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9751-6. doi: 10.1073/pnas.1511810112. Epub 2015 Jul 20.
Fu C, Xu J, Li RJ, Crawford JA, Khan AB, Ma TM, Cha JY, Snowman AM, Pletnikov MV, Snyder SH. Inositol Hexakisphosphate Kinase-3 Regu...
Thu 30th July 2015
Publications - July 2015
Publications from Primary Faculty Members - July 2015
Golden EJ, Benito-Gonzalez A, Doetzlhofer A. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73. doi: 10.1073/pnas.1501077112. Epub 2015 Jul 2.
Hand, RA. Khalid, S, Tam, E, Kolodkin, AL. Axon Dynamics during Neocortical Laminar Innervation. Cell Rep. 2015 Jul 14;12(2):172-82. doi: 10.1016/j.celrep.2015.06.026. Epub 2015 Ju...
Wed 17th June 2015
Publications - June 2015
Publications from Primary Faculty Members - June 2015
Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, Lee HK. Vision Loss Shifts the Balance of Feedforward and Intracortical Circuits in Opposite Directions in Mouse Primary Auditory and Visual Cortices.
J Neurosci. 2015 Jun 10;35(3)8790-801. doi: 10.1523/JNEUROSCI.4975-14.2015.
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