Andrew Jaffe PhD

Lead Investigator, Lieber Institute for Brain Development; Assistant Professor of Mental Health and Neuroscience

ajaffe@jhu.edu
Telephone Number: 443-287-6864

Lieber Institute for Brain Development
855 N Wolfe St, Ste 300
Baltimore, MD 21205
Lab Page
Areas of Research
Neurobiology of Disease

Graduate Program Affiliations

Human Genetics Training Program

Neuroscience Training Program

 

Human Brain Genomics

I work at the intersection of biological psychiatry, computational biology, and biostatistics, leveraging large human brain and human pluripotent stem cell datasets to better understand how genomic signatures associate with brain development and subsequent dysregulation in mental illness. My research consists of several broad, and often overlapping, domains: 1) developing and applying computational approaches in genomic data to identify new biological insights in development and aging, 2) identifying molecular signatures related to causes and consequences of mental disorders in human postmortem brain samples and in neurons derived from human iPSCs, and 3) developing statistical methodology and corresponding software tools for the spatial analysis of epigenomic and transcriptomic data and 4) developing approaches to process and normalize genomic data for biological inference. 


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