Valina Dawson PhD

Professor of Neurology, Neuroscience, and Physiology

Chi, Z., J. Zhang, A. Tokunaga, M.M. Harraz, S.T. Byrne, A. Dolinko, J. Xu, S. Blackshaw, N. Gaiano, T.M. Dawson, and V.L. Dawson. “Botch (NPG7) Promotes Neurogenesis by Antagonizing Notch.” PMID: 22445366 Dev. Cell 22(4): 707-720 (2012).

Xiong Y, C Yuan, R Chen, TM Dawson, and VL Dawson. “ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2.” J Neurosci. 32 3877-3886 (2012).  [pdf]

Kang, H.C., Y-I Lee, J-H Shin, S.A. Andrabi, Z Chi, J-P Gagne, Y. Lee, H.S Ko, B.D. Lee, G.G. Poirier, V.L. Dawson, and T.M. Dawson. “Iduna is a Poly(ADP-Ribose) (PAR)-Dependent E3 Ubiquitin Ligase that Regulates DNA Damage.” PMID: 21825151, [EPub August 2011] Proc Natl Acad Sci U S A. 108(34):14103-8 (2011).

Andrabi, S.A.*, H.C. Kang*, J-F Haince, Y-I Lee, J. Zhang, Z. Chi, A.B. West, R.C. Koehler, G.G. Poirier, T.M. Dawson and V.L. Dawson. “Iduna Protects the Brain from Glutamate Excitotoxicity and Stroke by Interfering with Parthanatos.” *equal contribution. PMID:21602803 [EPub May 2011] Nat. Med. 17(6):692-9 (2011).

Zhang, J., Y. Wang, Z. Chi, M.J. Keuss, Y-M E. Pai, H.C. Kang, J. Shin, A. Bugayenko, H. Wang, Y. Xiong, M.V. Pletnikov, M.P. Mattson, T.M. Dawson, V.L. Dawson.  “Thorase, A Novel AAA+ ATPase, Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior.” PMID: 21496646, PMCID: PMC3085003, Cell, 145(2):284-99 (2011).

Xiong, Y., C.E. Coombes, A. D. Gitler, J.M. McCaffery, W.J. Bowers, V.L. Dawson, T.M. Dawson, and D.J. Moore. “GTPase Activity Plays a Key Role in the Pathobiology of LRRK2.” PMID: 20386743, PMCID: PMC2851569, PLoS Genet. 6(4): e1000902 doi:10.1371/journal.pgen.1000902 (2010).

Ramsden, N., J. Perrin, Z. Ren, B.D. Lee, N. Zinn, V.L. Dawson, D. Tam, M. Bova, M. Delling, G. Drewes, M. Bantscheff, F. Bard, T.M. Dawson, C. Hopf. “Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson’s disease-related toxicity in human neurons.” PMID: 21812418 doi: 10.1021/cb2002413. [Epub ahead of print]ACS Chemical Biology 6(10):1021-8 (2011).  [pdf]

Lee B.D., J.-H. Shin, J. VanKampen, L. Petrucelli, A.B. West, H.S. Ko1, Y.-I. Lee, K.A. Maguire-Zeiss, W.J. Bowers, H.J. Federoff, V.L. Dawson and T.M. Dawson. “Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson’s disease.” PMID: 20729864, PMCID: PMC2935926, [Epub August 2010] Nat Med 16(9): 998-1000 (2010).

Zheng, S., S. Eacker, S.J. Hong, R.M. Gronostajski, T.M. Dawson, and V.L. Dawson. "N-Methyl-D-Aspartate-Induced Neuronal Survival is Mediated Through Nuclear Factor I-A" PMID: 20516644, PMCID: PMC2898580,  [Epub June 2010] J. Clin. Invest.120(7):2446-56 (2010).

Andres-Mateos, E., R. Mejias, M. Sasaki, X. Li, B.M. Lin, S. Biskup, L. Zhang, R. Banerjee, B. Thomas, L. Yang, G. Liu, M F. Beal, D.L. Huso, T.M. Dawson and V.L. Dawson. “Unexpected Lack of Hypersensitivity in LRRK2 Knock-out Mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).” PMID: 20016100 PMCID: PMC2846613,  J. Neurosci. 29:15846-15850 (2009).

Ko, H.S. R. Bailey, W.W. Smith, Z. Liu, J-H. Shin, Y-I. Lee, Y-J. Zhang, H. Jiang, C.A. Ross, D.J. Moore, C. Patterson, L. Petrucelli, T.M. Dawson and V.L. Dawson. “CHIP Regulates Leucine-Rich Repeat Kinase-2 (LRRK2) Ubiquitination, Degradation and Toxicity.” [Epub 2009 Feb] PMID: 19196961, PMCID: PMC2650345, Proc. Natl. Acad. Sci. U.S.A.  106(8):2897-902 (2009).