Richard Huganir PhD

Professor and Director Department of Neuroscience

Lagerlöf, O., Slocomb, J.E., Hong, I., Aponte, Y., Blackshaw, S., Hart, G.W., Huganir, R.L. (2016) The nutrient sensor OGT in PVN neurons regulates feeding. Science. 351(6279): 1293-6.

Widagdo, J., Chai, Y.J., Ridder, M.C., Chau, Y.Q., Johnson, R.C., Sah, P., Huganir, R.L., Anggono, V. (2015) Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation.  Cell Reports. Pii:S2211-1247(15)000028-5.

Zhang, Y., Cudmore, R., Lin, D-T., Linden, D., Huganir, R.L. (2015)  Visualization of NMDA Receptor-Dependent AMPA Receptor Synaptic Plasticity In Vivo. Nature Neuroscience. 18(3): 402-7.

Araki, Y., Zeng, M., Zhang, M., Huganir, R.L.  (2014) Rapid Exclusion of SynGAP from Synaptic Spines Triggers AMPA Receptor Insertion and Spine Enlargement During LTP. Neuron.  85(1): 173-189.

Diering, G., Gustina, A., Huganir, R.L. (2014)  PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity.  Neuron.  84(4): 790-805.

Sia, G.M., Clem, R. L., Huganir, R.L.  (2013) The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice.  Science.  342(6161): 987-91.

Volk, L.J., Bachman, J.L., Johnson, R., Yu, Y., Huganir, R.L. (2013) PKM-Z is not required for hippocampal synaptic plasticity, learning and memory.  Nature. 493(7432): 420-3. 

Thomas, G.M., Hayashi, T., Chiu, S.L., Chen, C.M., Huganir, R.L. (2012) Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Neuron. 73(3):482-96.

Makuch, L., Volk, L., Anggono, V., Johnson, R.C., Yu, Y., Duning, K., Kremerskothen, J., Xia, J., Takamiya, K., Huganir, R.L. (2011) Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron. 71(6):1022-9.

Makino, Y., Johnson, R.C., Yu, Y., Takamiya, K., Huganir, R.L. (2011)  Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. Proc Natl Acad Sci U S A. 108(20):8450-5.

Mejias, R., Adamczyk, A., Anggono, V., Niranjan, T., Thomas, G.M., Sharma, K., Skinner, C., Schwartz, C.E., Stevenson, R.E., Fallin, M.D., Kaufmann, W., Pletnikov, M., Valle, D., Huganir, R.L., Wang, T.  (2011) Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proc Natl Acad Sci USA. 108(12):4920-5.  

Clem, R., Huganir, R.L. (2010) Calcium-permeable AMPA receptor dynamics mediate fear memory erasure.  Science.  330(6007): 1108-12. 

Hayashi, T., Thomas, G., Huganir, R.L. (2009) Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron. 64(2): 213-226.

Lin, D.T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K., Huganir, R.L. (2009) Regulation of AMPA receptor GluR1 subunit extrasynaptic insertion events by 4.1N, phosphorylation and palmitoylation. Nat. Neurosci. 12(7): 879-87.

Sia, G.-M., Beique, J.-C., Rumbaugh, G., Cho, R., Worley, P.F., Huganir, R.L. (2007) Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron. 55(1): 87-102.

Steinberg, J.P., Takamiya, K., Shen, Y., Xia, J., Rubio, M.E., Yu, S., Jin, W., Thomas, G.M., Linden, D.J., Huganir, R.L.  (2006) Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 49(6): 845-60.

Chung, H.J., Steinberg, J.P., Huganir, R.L. and Linden, D.J. (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.

Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R.S., Wenthold, R.J., Gallagher, M., and Huganir, R.L. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell. 112:631-642.

Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M.F., and Huganir, R.L. (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature. 405:955-959.

Ehlers, M.D., Zhang, S., Bernhardt, J.P., and Huganir R.L. (1996) Inactivation of NMDA receptors by direct interaction of calmodulin with NR1 subunit. Cell 84:745-755.