Rejji Kuruvilla PhD

Associate Professor of Biology and Neuroscience

rkuruvilla@jhu.edu
Telephone Number: 410-516-2366
Fax Number: 410-516-5213

Johns Hopkins University
Department of Biology
3400 North Charles Street
Baltimore, MD 21218-2685
Room: Mudd Hall 224A
Lab Page
Areas of Research
Developmental Neuroscience
Cellular + Molecular Neuroscience

Graduate Program Affiliations

CMDB (Cellular, Molecular, Developmental Biology and Biophysics Graduate Program

Neuroscience Training Progam

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    Compartmentalized cultures of rat sympathetic neurons

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    Tyrosine Hydroxylase-positive sympathetic neurons in the Superior Cervical Ganglia in a new-born mouse pup

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    Whole mount Tyrosine Hydroxylase immunostaining shows the sympathetic chain in a E16.5 mouse embryo

Growth factor signal transduction and trafficking in neuronal development

The proper functioning of the nervous system relies on the establishment of precise neuronal circuits. These neuronal circuits are largely formed during early development. To form functional neuronal circuits, neurons receive specific information in the form of extracellular cues from the target tissues that they innervate. The family of neurotrophins provides one of the best examples of these target-derived instructive cues that regulate diverse developmental events in the vertebrate nervous system, including survival, axonal and dendritic growth and synapse formation. Using a combination of cell biological, biochemical and imaging techniques as well as mouse genetics, we are actively pursuing two lines of research; 1. How neurotrophic factors coordinate neuronal development by regulating the neuronal endocytic machinery, and 2. Growth factor signaling pathways underlying axonal growth, morphology and innervation of target tissues during development.


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