Jeffrey Rothstein MD, PhD

Professor of Neurology




Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Liu Y, Jin L, Zhang P, Hoffman P, Pellerin L, Magistretti PJ, Rothstein JD. (2012) Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature, 2012, in press.

Brotherton TE, Li Y, Cooper D, Gearing M, Julien JP, Rothstein JD, Boylan K, Glass JD. (2012) Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS. Proc Natl Acad Sci USA. 2012 Apri3; 109 (14):5505-10.  Epub 2012 Mar 19. [pdf]

Benediktsson AM, Marrs GS, Tu JC, Worley PF, Rothstein JD, Bergles DE, Dailey ME. (2012) Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia. 2012 Feb; 60(2):175-88. Epub 2011 Nov 2.  [pdf]

Gao Y, Perkins EM, Clarkson YL, Tobia S, Lyondon AR, Jackson M, Rothstein JD. (2011) β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. J Neurosci 2011 Nov 16;31(46):16581-90.  [pdf]

Roux L, Benchanane K, Rothstein JD, Bonvento G, Giaume C. (2011) Plasticity of astroglial networks in olfactory glomeruli.  Proc Natl Acad Sci USA. 2011 Nov 8; 108(45):18442-6.  Epub 2011 Oct 13.  [pdf]

Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ. (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 2011 Oct 20; 72(2):257-68.  Epub 2011 Sep 21. [pdf]

Sattler R, Ayukawa Y, Coddington L, Sawa A, Block D, Chipkin R, Rothstein JD. (2011) Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.  Exp Neurol. 2011 Dec;232(2):203-11. Epub 2011 Sep 16.  [pdf]

Ghosh M, Yang Y, Rothstein JD, Robinson MB. (2011) Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes. J Neurosci. 2011 Jun 22;31(25):9159-69.  [pdf]

Yang Y, Vidensky S, Jin L, Jie C, Lorenzini I, Frankl M, Rothstein JD. (2011) Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia. 2011 Feb;59(2):200-7.  [pdf]

Kang SH, Fukaya M, Yang JK, Rothstein JD, Bergles DE. (2010) NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron. 2010 Nov 18; 68(4):668-81.  [pdf]

Paukert M, Huang YH, Tanaka K, Rothstein JD, Bergles DE. (2010) Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. J Neurosci. 2010 May 26; 30(21):7290-9.  [pdf]

Pascuzzi RM, Shefner J, Chappell AS, Bjerke JS, Tamura R, Chaudhry V, Clawson L, Haas L, Rothstein JD. (2010) A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010 May 3; 11(3):266-71.

Perkins EM, Clarkson YL, Sabatier N, Longhurst DM, Millward CP, Jack J, Toraiwa J, Watanabe M, Rothstein JD, Lyndon AR, Wyllie DJ, Dutia MB, Jackson M. (2010) Loss of beta-III spectrin leads to Purkinjie cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. J Neurosc. 2010 Apr 7; 30(14):4857-67.  [pdf]

Yang Y, Gozen O, Vidensky S, Robinson MB, Rothstein JD. (2010) Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.  Glia. 2010 Feb; 58(3):277-86.  [pdf]

Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Rabinson MB, Rothstein JD. (2009) Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1.  Neuron. 2009 Mar 26; 61(6):880-94. [pdf]

Lepore AC, Rauck B, Dejea C ,Pardo AC, Rao MS, Rothstein JD, Maragakis NJ. (2008) Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci. 2008 Nov; 11(11):1294-301.  Epub 2008 Oct 19.  [pdf]