Shanthini Sockanathan PhD

Professor of Neuroscience

Yan, Y, Wldayka, C., Fujii, J., and Sockanathan, S. (2015) Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nature Comm. 6; 6:7006

Choi, J.H., Park, S.J. and Sockanathan, S. (2014) Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons. Development 141, 1151-1160.

Park S, Lee C, Sabharwal P, Zhang M, Meyers C, Sockanathan S.  (2013)  GDE2 Promotes Neurogenesis by Glycosylphosphatidylinositol-Anchor Cleavage of Reck.  Science 339:324-339.  [pdf]

Rodriguez M, Choi J, Park S, Sockanathan S.  (2011) Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation.   Development 2012 Oct; 139(20):3870-9. Epub 2012 Sep 5 [pdf]

Sabharwal P, Lee C, Park S, Rao M, Sockanathan S. (2011) GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron. 2011 Sep 22; 71(6):1058-70. Epub 2011 Sep 21.  [pdf]

Periz G, Yan Y, Bitzer ZT, Sockanthan S. (2010) GDP-bound Galphai2 regulates spinal motor neuron differentiation through interaction with GDE2. Dev Biol. 2010  May 1; 341(1):213-21. Epub 2010 Mar 1.

Yan, Y., Sabharwal, P., Rao, M., and Sockanathan, S. (2009) The antioxidant Prdx1 controls motor neuron differentiation by thiol-redox dependent activation of GDE2. Cell 138, 1209-1221. (NIHMS:131140) [pdf]

Zhuang BQ, Su YS, Sockanathan S (2009) FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling. Neuron 2009 Feb 12; 61:359-372.

Ji SJ, Periz G, Sockanathan S. (2009) Nolz1 is induced by retinoid signals and controls motor neuron subtype identity through distinct repressor activities.  Development 2009 Jan; 136:231-240. Epub 2008 Dec 4.

Rajaii F, Bitzer ZT, Qing X, Sockanathan S. (2008) Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival and fate specification. Dev Bio 2008 Apr 15; 316:371-382. Epub 2008 Feb 13.

Ji SJ, Zhuang B, Falco C, Schneider A, Schuster-Gossler A, Gossler A, Sockanathan S (2006) Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons. Dev Biol. 2006  Sep 1; 297:249-61.  Epub 2006 May 19.  [PDF]

Rao M, Sockanathan S. (2005) Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science 2005 Sep 30; 309:2212-2215.  [PDF]

Rao M, Baraban J, Rajaii F, Sockanathan S. (2004) In vivo comparative study of RNAi methodologies by in ovo electroporation in the chick embryo. Dev Dynamics 2004 Nov; 231:592-600.  [PDF]

Sockanathan S, Perlmann T, Jessell TM. (2003) Retinoid receptor signaling in postmitotic motor neurons regulates Rostrocaudal positional identity and axonal projection pattern. Neuron 2003 Sep 25; 40:97-111.  [PDF]

Novitch B, Wichterle H, Jessell TM, Sockanathan S. (2003) A requirement for retinoic acid mediated transcriptional activation in ventral neural tube patterning and motor neuron specification. Neuron 2003 Sep 25; 40:81-95.  [PDF]

Arber S, Han B, Smith M, Mendelsohn M, Jessell TM, Sockanathan S. (1999) Requirement for the Homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 1999 Aug; 23:659-674.  [LINK]

Sockanathan S, Jessell TM. (1998) Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 1998 Aug 21; 94:503-14.  [LINK]