Kathryn Wagner MD, PhD

Professor of Neurology, Director of Center for Genetic Muscle Disorders

wagnerk@kennedykrieger.org
Telephone Number: 443-923-9525
Fax Number: 443-923-9545

Center for Genetic Muscle Disorders
The Kennedy Krieger Institute
707 Broadway
Baltimore, MD 21205
Room: 406
Lab Page
Areas of Research
Neurobiology of Disease
Cellular + Molecular Neuroscience

Graduate Program Affiliations

Neuroscience Training Program

Cellular and Molecular Medicine Program

The main areas of emphasis in our lab are:

Muscle Growth and Regeneration: Normal skeletal muscle has a remarkable ability to regenerate. However, in many diseases, skeletal muscle does not recover from injury but is gradually replaced with fat and fibrotic tissue.  A longstanding goal of our lab is to determine how to best influence diseased muscle to successfully regenerate.  Through cell culture and animal models, we study major myokines (IGF-1, myostatin) and their downstream effectors to determine how the various factors interact to control muscle growth and function. 

Muscular Dystrophy: There are dozens of progressive genetic disorders of muscle, known as muscular dystrophies.  Although the causative mutations for most of these diseases are now known, their pathophysiology remains unclear.  We study various existing disease models of muscular dystrophy, and develop novel animal models for conditions not widely studied. This includes xenografting human muscle into immunodeficient mice for a preclinical model of human muscle. 

Therapy Development: There are few treatments for muscle disorders and no approved therapies to aid muscle regeneration.  To address this need, we use disease models for preclinical studies with adenoassociated viral vectors, stem cell therapies, and novel pharmacological agents.  Much of this work is funded through a Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center.


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