Philip Wong PhD

Professor of Pathology

Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C and Wong PC: The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model. Nature Communications, DOI: 10.1038/ncomms 12082, July 2016.

Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL and Wong PC: PTBP1 and PTBP2 repress nonconserved cryptic exons. Cell Reports 17: 104-113, 2016.  DOI:10.1016/j.celrep.2016.08.071.

LaClair KD, Donde A, Ling JP, Jeong YH, Chhabra R, Martin LJ and Wong PC: Depletion of TDP-43 decreases fibril and plaque b-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model. Acta Neuropathologica 132: 859-873, 2016. DOI: 10.1007/s00401-016-1637-y.

Shyam R, Ren Y, Lee J, Braunstein KE, Mao H-Q and Wong PC: Intraventricular delivery of siRNAs nanoparticles to the central nervous system. Molecular Therapy Nucleic Acids 4, e242, 2015 May 12.

Ling JP, Pletnikova O, Troncoso J and Wong PC: TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science 349:650-655, 2015.

Chow VW, Savonenko AV, Melnikova T, Kim H, Price DL, Li T and Wong PC:  Modeling an anti-amyloid combination therapy for Alzheimer’s Disease.  Science Translational Medicine 2:1-11, 2010  Full Article   Abstract

Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee H-K and Wong PC: BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-b Amyloidogenesis is Essential for Cognitive, Emotional and Synaptic Functions.  J. Neuroscience 25:11693–11709, 2005.  [PDF]

Ma G, Li T, Price DL and Wong PC:  Aph-1a is the principal mammalian Aph-1 isoform present in g-secretase complexes during embryonic development.  J. Neuroscience 25:192-198, 2005.  [PDF]

Li T, Ma G, Cai H, Price DL, Wong PC: Nicastrin is required for assembly of presenilin/g-secretase complexes to mediate Notch Signaling, and for processing and trafficking of b-APP in mammals. J. Neuroscience 23: 3272-3277, 2003. [PDF]

Subramaniam JR, Lyons WE, Liu J, Bartinakas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD and Wong PC: Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nature Neuroscience 5:301, 2002.[PDF]

Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL and Wong PC: BACE1 is the major b-secretase for generation of Ab peptides by neurons. Nature Neuroscience 4: 233, 2001.  [PDF]