Ahmet Hoke M.D., Ph.D
Professor of Neurology and Neuroscience Director of Neuromuscular Divisionahoke@jhmi.edu
Telephone Number: 410-955-2227
Fax Number: 410-502-5459
855 N. Wolfe St.
Baltimore, MD 21205
Neurobiology of peripheral neuropathies; development and regeneration of the peripheral nervous system
My laboratory is interested in basic biology of peripheral axons and Schwann cells and disorders affecting the peripheral nervous system. We use in vitro and in vivo models of peripheral neuropathies (HIV-associated sensory neuropathies, chemotherapy-induced toxic neuropathies and diabetic neuropathy) to study the mechanism of axonal damage and identify therapeutic targets for drug development. In addition, we study mechanisms of axonal degeneration and regeneration in traumatic injury and develop nanofiber based nerve graft conduits. We utilize engineered stem cells as therapeutic gene delivery tools to promote axonal regeneration in chronically denervated nerves as seen traumatic injuries and many degenerating disorders of the peripheral nervous system such as amyotrophic lateral sclerosis and inherited neuropathies.