George Uhl MD, Ph.D
Adjunct Professor of Neurology Adjunct Professor of Neuroscience Adjunct Professor of Mental Health JHBSPH Chief, Molecular Neurobiology, NIDA-IRP, NIHGUHL@intra.nida.nih.gov
Telephone Number: 443-740-2799
Fax Number: 443-740-2122
333 Cassell Drive, Suite 3510
Baltimore, MD 21224
Cell adhesion molecules and postGWAS studies of addiction
The Molecular Neurobiology laboratories use postGWAS approaches to a) define roles for addiction associated allelic variations in human brain, mouse brain, and mouse behavior and b) use groups of human allelic variants to predict developmental courses of uptake of use of addictive substances, ability to quit smoking and individual differences in pain responses. Other phenotypes of current interest include cognitive abilities, Attention-deficit Hyperactivity Disorder, Restless Leg syndrome and Parkinson's diseases in humans and in mouse models. Recent work provides increasing evidence for contributions of cell adhesion molecule "bar codes" to specification of the connectome, roles of allelic variants in CAM genes in altering these connections and contributing to individual differences in vulnerabilities to many brain-based disorders, and potential roles of CAMs as targets for novel therapeutics that target these genes and these connections.