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Richard O'Brien M.D., Ph.D

Associate Professor of Neurology

robrien@jhmi.edu
Telephone Number: 410-550-8703
Fax Number: 410-550-8715
Department of Neurology
Johns Hopkins University School of Medicine
5200 Eastern Avenue
Mason F. Lord Center Tower, Suite 5100
Baltimore, MD 21224
Room: Mason F Lord Center Tower Suite 5100 JHBMC
Graduate Program Affiliations:

Neuroscience Graduate Program


Molecular Aspects of Synapse Formation in the Brain

This laboratory investigates the molecular mechanisms that regulate the development and maintenance of excitatory synapses in the central nervous system. Particular attention is devoted to isolating presynaptic factors that regulate the accumulation of ionotropic glutamate receptors in the spinal cord and hippocampus as well as mechanisms of synaptic plasticity accompanying motor learning. In addition, how amyloid precursor protein processing is modulated by synaptic activity is also a focus. Techniques utilized include expression cloning, immunohistochemistry and electrophysiology.