Wenzhen Duan MD/Ph.D
Associate Professor of Psychiatry and Behavioral Scienceswduan2@jhmi.edu
Telephone Number: (410) 502-2866
Fax Number: (410) 614-0013
Department of Psychiatry and Behavioral Sciences
600 N. Wolfe St.
Baltimore, MD 21287
Translational Neurobiology Research
Our research program focuses on understanding the pathogenesis, molecular mechanisms and developing experimental therapeutics for neurodegenerative diseases, particularly focus on Huntington’s disease (HD) and Parkinson’s disease (PD).
A multifaceted array of experimental models of neurodegenerative disorders is being employed in our laboratory in order to establish the molecular and cellular changes that occur in these neurodegenerative disorders. Data obtained in the experimental models are integrated with data obtained in therapeutic trial studies to determine why neuronal dysfunction and degeneration occur in the disease condition. In addition to identifying the molecular and cellular mechanisms that lead to neuronal degeneration, the research projects in our laboratory focus on discovering new therapeutic target(s) for HD and PD; meanwhile we are validating biomarkers for therapeutic evaluation in the preclinical trials.
A major effort underway is to understand the contribution of mitochondrial dysfunction and abnormalities in energy metabolism to neurodegeneration in HD. We are interested in understanding the role of protein posttranslational modifications (PTMs) in the process of neurodegeneration. In addition, we have established structural MRI measures as a biomarker in preclinical trials of HD and are expanding our effort to develop metabolic and functional MRI measures as early biomarkers in mouse models. Our current effort focuses on understanding the cellular and molecular changes underlying the neuroimage findings in both gray matter and white matter of brain, and the correlation of neuroimage changes with functional consequence of clinical manifestation in HD.