Andrew Jaffe PhD

Lead Investigator, Lieber Institute for Brain Development; Associate Professor of Mental Health and Neuroscience




Selected publications:
1.Jaffe AE, Shin J, Collado-Torres L, Leek JT, Tao R, Li C, Gao Y, Jian Y, Maher BJ, Hyde TM, Kleinman JE, Weinberger DR+. Developmental regulation of human cortex transcription at base resolution. Nat Neurosci. 2015 Jan;18(1):154-61. PMID: 25501035
2.Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR, Kleinman JE. Mapping DNA methylation across development, genotype, and schizophrenia in the human frontal cortex. Nature Neuroscience. 2016 Jan;19(1):40-7. PMID: 26619358. 
3.Jaffe AE, Tao R, Norris A, Kealhofer M, Nellore A, Jia Y, Hyde TM, Kleinman JE, Straub RE, Leek JT, Weinberger DR. qSVA framework for RNA quality correction in differential expression analysis. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7130-7135. PMID: 28634288. 
4.Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres LΨ, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich B, Maher BJ, Deep-Soboslay A, The BrainSeq Consortium, Cross A, Brandon NJ, Leek JT, Hyde TM, Kleinman JE, Weinberger DR+. Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nat Neurosci. 2018 Aug;21(8):1117-1125. PMID: 30050107