Pankaj Jay Pasricha MD

Dir., Johns Hopkins Center for Neurogastroenterology, Prof. of Medicine and Neurosciences, Johns Hopkins School of Medicine, Prof. of Innovation Management, Johns Hopkins Carey School of Business

Pasricha PJ, Ravich WJ, Hendrix TR, Sostre S, Jones B, Kalloo AN. Intrasphincteric botulinum toxin injection for the treatment of achalasia. N Engl J Med 1995;332:774-8.

Hoogerwerf WA, Zou L, Shenoy M, Micci MAM, Lee-Hellmich H,  Xiao SY, Winston, JH,  Pasricha PJ. The proteinase-activated receptor 2 is involved in nociception. J Neuroscience 2001;21:9036-42.

Hoogerwerf WA, Shenoy M, Winston JH, Xiao SY, He Z, Pasricha PJ.  Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain.  Gastroenterology 2004;127:883-91.

Xu GY, Winston JH, Shenoy MM, Yin H, Pasricha PJ. .Enhanced excitability and suppression of A-type potassium current of pancreas specific afferent neurons in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2006;291:G424-31.

Winston J, Shenoy M, Medley D, Naniwadekar A, Pasricha PJ. The Vanilloid Receptor Initiates and Maintains Colonic Hypersensitivity Induced by Neonatal Colon Irritation in Rats. Gastroenterology 2007 Feb;132(2):615-27.

Xu G, Winston J, Shenoy M, Yin H, Pendyala S, Pasricha PJ. Transient Receptor Potential Vanilloid 1 Mediates Hyperalgesia and Is Upregulated in a Rat Model of Painful Chronic Pancreatitis. Gastroenterology 2007: Jun 20

Xu GY, Shenoy M, Winston JH, Mittal S, Pasricha PJ. P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity.Gut. 2008 Feb 12; [Epub ahead of print]

Liu LS, Winston JH, Shenoy MM, Song GQ, Chen JD, Pasricha PJ: A rat model of chronic gastric sensorimotor dysfunction resulting from transient neonatal gastric irritation. Gastroenterology 2008, 134(7):2070-2079.

Zhu Y, Colak T, Shenoy M, Liu L, Pai R, Li C, Mehta K, Pasricha PJ. Nerve Growth Factor Modulates TRPV1 Expression and Function and Mediates Pain in Chronic Pancreatitis. Gastroenterology. 2011 Jul;141(1):370-7

Liu L,  Li Q, Sapolsky R, Liao M, Mehta K, Bhargava A, Pasricha PJ. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. PLOS One. 2011 PLoS One. 2011 May 12;6(5):e19498.

Kulkarni S, Zou B, Hanson J, Micci MA, Tiwari G, Becker L, Kaiser M, Xie XS, Pasricha PJ. Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype. Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G644-55.

Grover M, Farrugia G, Lurken MS, Bernard CE, Faussone-Pellegrini MS, SmyrkTC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Ünalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Pasricha PJ; NIDDK Gastroparesis Clinical Research Consortium. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011 May;140(5):1575-85.

Becker L, Kulkarni S, Tiwari G, Micci MA, Pasricha PJ. Divergent fate and origin of neurosphere-like bodies from different layers of the gut. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 23. [Epub ahead of print]

Grover M, Bernard CE, Pasricha PJ et al Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium. Neurogastroenterol Motil. 2012 Feb 17. [Epub ahead of print]

Parkman HP, Van Natta ML, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Snape WJ, Koch KL, Hasler WL, Farrugia G, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, Pasricha PJ. Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial. JAMA 2013 Dec 25;310(24):2640-9. d10.1001/jama.2013.282833.

Patel YA, Pasricha PJ. Enteric Neuromodulation for the Gut and Beyond. Cold Spring Harb Perspect Med. 2019 Mar 11. pii: a034355. doi: 10.1101/cshperspect.a034355. [Epub ahead of print] PubMed PMID: 30858329.

Hagiwara SI, Kaushal E, Paruthiyil S, Pasricha PJ, Hasdemir B, Bhargava A.Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia. PLoS One. 2018 Sep 7;13(9):e0203704. doi: 10.1371/journal.pone.0203704. eCollection 2018. PubMed PMID: 30192883; PubMed Central PMCID: PMC6128656.

Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F. NaV1.1 inhibition can reduce visceral hypersensitivity. JCI Insight. 2018 Jun 7;3(11). pii: 121000. doi: 10.1172/jci.insight.121000. eCollection 2018 Jun 7. PubMed PMID: 29875317; PubMed Central PMCID: PMC6124407.

Liu L, Zhu Y, Noë M, Li Q, Pasricha PJ. Neuronal Transforming Growth Factor beta Signaling via SMAD3 Contributes to Pain in Animal Models of Chronic Pancreatitis. Gastroenterology. 2018 Jun;154(8):2252-2265.e2. doi: 10.1053/j.gastro.2018.02.030. Epub 2018 Mar 2. PubMed PMID: 29505748; PubMed Central PMCID: PMC5985212.

Tang SC, Shen CN, Lin PY, Peng SJ, Chien HJ, Chou YH, Chamberlain CE, Pasricha PJ. Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology. Diabetologia. 2018 Jan;61(1):158-167. doi: 10.1007/s00125-017-4408-y. Epub 2017 Sep 1. PubMed PMID: 28864913.

Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP, Bogunovic M, Pasricha PJ. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3709-E3718. doi: 10.1073/pnas.1619406114. Epub 2017 Apr 18. PubMed PMID: 28420791; PubMed Central PMCID: PMC5422809.

Sinha S, Fu YY, Grimont A, Ketcham M, Lafaro K, Saglimbeni JA, Askan G, Bailey JM, Melchor JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturk O, Baker L, Park Y, Kurtz RC, Tuveson D, Leach SD, Pasricha PJ. PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk. Cancer Res. 2017 Apr 15;77(8):1868-1879. doi: 10.1158/0008-5472.CAN-16-0899-T. Epub 2017 Apr 6. PubMed PMID: 28386018; PubMed Central PMCID: PMC5471615.

Becker L, Nguyen L, Gill J, Kulkarni S, Pasricha PJ, Habtezion A. Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system. Gut. 2018 May;67(5):827-836. doi: 10.1136/gutjnl-2016-312940. Epub 2017 Feb 21. PubMed PMID: 28228489; PubMed Central PMCID: PMC5565713.

Lin PY, Peng SJ, Shen CN, Pasricha PJ, Tang SC. PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3D pancreatic duct lesion histology. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G412-22. doi: 10.1152/ajpgi.00071.2016. Epub 2016 Jun 23. PubMed PMID: 27340125; PubMed Central PMCID: PMC6347070.

Moran RA, James T, Pasricha PJ. Pancreatic pain. Curr Opin Gastroenterol. 2015 Sep;31(5):407-15. doi: 10.1097/MOG.0000000000000204. Review. PubMed PMID: 26154428.

Hu Y, Liu Z, Yu X, Pasricha PJ, Undem BJ, Yu S. Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G149-57. doi: 10.1152/ajpgi.00097.2014. Epub 2014 May 29. PubMed PMID: 24875100; PubMed Central PMCID: PMC4101676.

Li C, Micci MA, Murthy KS, Pasricha PJ. Substance P is essential for maintaining gut muscle contractility: a novel role for coneurotransmission revealed by botulinum toxin. Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G839-48. doi: 10.1152/ajpgi.00436.2012. Epub 2014 Apr 3. PubMed PMID: 24699329; PubMed Central PMCID: PMC4347745.

Becker L, Peterson J, Kulkarni S, Pasricha PJ. Ex vivo neurogenesis within enteric ganglia occurs in a PTEN dependent manner. PLoS One. 2013;8(3):e59452. doi: 10.1371/journal.pone.0059452. Epub 2013 Mar 19. PubMed PMID: 23527198; PubMed Central PMCID: PMC3602370.

Liu YA, Chung YC, Pan ST, Shen MY, Hou YC, Peng SJ, Pasricha PJ, Tang SC. 3-D imaging, illustration, and quantitation of enteric glial network in transparent human colon mucosa. Neurogastroenterol Motil. 2013 May;25(5):e324-38. doi: 10.1111/nmo.12115. Epub 2013 Mar 17. PubMed PMID: 23495930.