Johns Hopkins University, Department of Neuroscience
 

 

 

 

 

Jonathan  Pevsner, Ph.D

Associate Professor of Neuroscience

Telephone Number:  (443) 923-2686

Fax Number:   (443) 923-2695

Johns Hopkins University

Kennedy Krieger Institute

707 N. Broadway

Baltimore, MD 21205

Room:  400D Kennedy Krieger Institute

pevsner@kennedykrieger.org

 

Molecular Basis of Neurological Disorders

      The Pevsner lab studies the molecular basis of childhood brain disorders. The diseases we study include Down syndrome, other chromosomal disorders, and lead poisoning. The goal of the research is to investigate molecular defects leading to a disease state. By identifying genes and proteins implicated in a disease process, we may develop rational therapeutic strategies for treatment. Another goal is to identify genes and proteins that serve as markers for diseases. The approaches we take to study brain diseases include gene expression using DNA microarrays, and analysis of chromosomal changes. The lab has developed web-based software tools: DRAGON (for annotating and visualizing gene expression data), SNOMAD (Standardization and Normalization of Microarray Data), and SNPscan (a tool for visualizing high density single nucleotide polymorphism [SNP] data).



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