For all the latest news from the Solomon H. Snyder Department of Neuroscience
For all the latest news from the Solomon H. Snyder Department of Neuroscience
Congratulations to Dr. Richard Huganir who has been named a Bloomberg Distinguished Professor! Dr. Huganir is the Professor and Director of the Department of Neuroscience, Director of the Kavli Neuroscience Discovery Institute, and Co-Director of the Brain Science Institute.
Publications from Primary Faculty Members - April 2018:
de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S. Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina. Development. 2018 Apr 12. pii: dev.159970. doi: 10.1242/dev.159970. [Epub ahead of print]
Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandey A, Huganir RL. Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3827-E3836. doi: 10.1073/pnas.1720956115. Epub 2018 Apr 2.
Newman EA, Kim DW, Wan J, Wang J, Qian J, Blackshaw S. Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Apr 18. pii: S0012-1606(17)30906-5. doi: 10.1016/j.ydbio.2018.04.012. [Epub ahead of print]
Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018 Apr 18;9(1):1526. doi: 10.1038/s41467-018-03948-9.
Xie T, Ho MC, Liu Q, Horiuchi W, Lin CC, Task D, Luan H, White BH, Potter CJ, Wu MN. A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep. 2018 Apr 10;23(2):652-665. doi: 10.1016/j.celrep.2018.03.068.
Scientists are trained to be meticulous when they speak about their work. That’s why David Linden likes getting his neuroscience colleagues tipsy. For years, after plying them with spirits, he has been asking brain researchers the same simple question: “What idea about brain function would you most like to explain to the world?” He reports, “I’ve been delighted with their responses. They don’t delve into the minutiae of their latest experiments or lapse into nerd speak. They sit up a little straighter, open their eyes a little wider, and give clear, insightful, and often unpredictable or counterintuitive answers.”
A new book, called THINK TANK, now available from Yale Press, is the result of those conversations. He’s invited a group of the world’s leading neuroscientists, including many from Johns Hopkins, to answer that key question in the form of a short essay.
You can read an excerpt on Amazon here:
Congratulations to Neuroscience Graduate Students Natalie Hamilton (in Dr. Alex Kolodkin's lab) and Jessie Benedict (in Dr. David Linden's lab) who were awarded National Science Foundation Graduate Research Fellowships for 2018!
Congratulations to Kyle Severson, a Neuroscience Graduate Student in Dr. Dan O'Connor's lab, who is one of the 2018 Young Investigators’ Day Winners. He was chosen to receive the The Bae Gyo Jung Research Award.
The Young Investigators’ Day will be held April 17, 2018, at 3 p.m. in the Mountcastle Auditorium in the Preclinical Teaching Building, 725 N. Wolfe St., Baltimore, MD 21205.
Richard Huganir and colleagues report success in using large-scale studies of proteins and high-tech chemical analysis to discover 164 proteins within synapses in mice that outlast neighboring proteins by weeks and months. These stable proteins, they say, may be part of the molecular machinery that governs long-term memory and learning—as well as loss of memory—in all mammals, including humans. A summary of their experiments is published the week of April 2 in the Proceedings of the National Academy of Sciences.
Paper link: https://doi.org/10.1073/pnas.1720956115
Publications from Primary Faculty Members - March 2018:
Day KA, Leech KA, Roemmich RT, Bastian AJ. Accelerating locomotor savings in learning: compressing four training days to one. J Neurophysiol. 2018 Mar 14. doi: 10.1152/jn.00903.2017. [Epub ahead of print]
Hughes EG, Orthmann-Murphy JL, Langseth AJ, Bergles DE. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018 Mar 19. doi: 10.1038/s41593-018-0121-5. [Epub ahead of print]
Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018 Mar 29. pii: eaan4665. doi: 10.1126/science.aan4665. [Epub ahead of print]
Larson VA, Mironova Y, Vanderpool KG, Waisman A, Rash JE, Agarwal A, Bergles DE. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Elife. 2018 Mar 29;7. pii: e34829. doi: 10.7554/eLife.34829.
Richard JM, Stout N, Acs D, Janak PH. Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure. Elife. 2018 Mar 22;7. pii: e33107. doi: 10.7554/eLife.33107.
Sbodio JI, Snyder SH, Paul BD. REDOX MECHANISMS IN NEURODEGENERATION: FROM DISEASE OUTCOMES TO THERAPEUTIC OPPORTUNITIES. Antioxid Redox Signal. 2018 Mar 21. doi: 10.1089/ars.2017.7321. [Epub ahead of print]
Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, Blackshaw S. A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods. 2018 Mar 19. doi: 10.1038/nmeth.4632. [Epub ahead of print]
Dr. Linden's "Writing About the Brain" Course teaches student how to write articles for a science public. Adithya Rajagopalan, a Graduate Student in the Neuroscience program, had his article published in Nautilus.
Seth Blackshaw is a professor of neuroscience, neurology and ophthalmology at the Johns Hopkins University School of Medicine. He recently published a paper describing newly identified brain cells in mice that play a major role in promoting sleep. On Nov. 13, 2017, Blackshaw joined Reddit’s Ask Me Anything and answered questions about his research.
Article in Nature volume 548, pages 582–587 (31 August 2017): Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
Dr. Blackshaw on Reddit: https://www.reddit.com/r/science/comments/7cmp94/science_ama_series_im_seth_blackshaw_i_study_the/
The Baltimore Brain Connect is a collaborative set of programming for this year's Brain Awareness Week. We have recently finalized the details of this line of programming and would like to invite all neuroscientists to participate where they are able.
Publications from Primary Faculty Members - February 2018:
Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness. Nat Neurosci. 2018 Feb 5. doi: 10.1038/s41593-018-0074-8. [Epub ahead of print]
Sasikumar D, Emeric E, Stuphorn V, Connor CE. First-Pass Processing of Value Cues in the Ventral Visual Pathway. Curr Biol. 2018 Feb 19;28(4):538-548.e3. doi: 10.1016/j.cub.2018.01.051. Epub 2018 Feb 8.
Athletes who make it to the Olympics have the speed or strength or whatever physical skills it takes to be among the best in the world in their respective sports. But Johns Hopkins University Neuroscientist Christopher Fetsch and colleagues say those who ultimately bring home gold have also honed the mind of a medalist.
Dr. Fetsch’s research focus at the Zanvyl Krieger Mind/Brain Institute is how the brain makes fast decisions during body motion. The principles he’s learning can be applied to how an Olympic skiier makes adjustments in mid-turn, or how a hockey player decides whether to shoot or pass in a given moment.
Publications from Primary Faculty Members - January 2018:
Chevée M, Robertson JJ, Cannon GH, Brown SP, Goff LA. Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons. Cell Rep. 2018 Jan 9;22(2):441-455. doi: 10.1016/j.celrep.2017.12.046.
Publications from Primary Faculty Members - December 2017:
Fischbach-Weiss, S, Reese, RM, Janak, PH. Inhibiting Mesolimbic Dopamine Neurons Reduces the Initiation and Maintenance of Instrumental Responding. Neuroscience. 2017 Dec 15. pii: S0306-4522(17)30874-6. doi: 10.1016/j.neuroscience.2017.12.003. [Epub ahead of print]
Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circ Res. 2017 Dec 26. pii: CIRCRESAHA.117.311983. doi: 10.1161/CIRCRESAHA.117.311983. [Epub ahead of print]
Paul, BD, Snyder, SH. Gasotransmitter Hydrogen Sulfide Signaling in Neuronal Health and Disease. Biochem Pharmacol. 2017 Dec 1. pii: S0006-2952(17)30700-1. doi: 10.1016/j.bcp.2017.11.019. [Epub ahead of print]
Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM10, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley P. FRMPD4 Mutations Cause X-linked Intellectual Disability and Disrupt Dendritic Spine Morphogenesis. Hum Mol Genet. 2017 Dec 18. doi: 10.1093/hmg/ddx426. [Epub ahead of print]
Scherer, PC, Zaccor, NW, Neumann, NM, Vasavda, C, Barrow, R, Ewald, AJ, Rao, F, Sumner, CJ, Snyder, SH. TRPV1 is a physiological regulator of μ-opioid receptors. Proc Natl Acad Sci U S A. 2017 Dec 4. pii: 201717005. doi: 10.1073/pnas.1717005114. [Epub ahead of print]
Publications from Primary Faculty Members - November 2017:
Hu, B, Niebur, E. A recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Dec;43(3):227-242. doi: 10.1007/s10827-017-0659-3. Epub 2017 Sep 19.
Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017 Nov 14. pii: S0896-6273(17)31021-8. doi: 10.1016/j.neuron.2017.10.029. [Epub ahead of print]
Three primary Neuroscience faculty were chosen to recieve 2017 Synergy Awards: Dr. Jay Baraban, Dr. Loyal Goff, Dr. Ulrich Mueller. Dr. Mark Wu, secondary in Neuroscience, was chosen to receive a 2017 Innovation Award. Congratulations!
Excerpt from Today Show Interview with Dr. Mark Mattson
"We find that in the animals, the intermittent fasting reduces brain inflammation," said Mark Mattson, chief of laboratory of neurosciences at the National Institute on Aging in Baltimore, Maryland. Mattson also noted that in mice studies, intermittent fasting dramatically improved heart health and prevented the symptoms of Alzheimer's.
"Intermittent fasting improves cognition, that is learning and memory, and protects nerve cells from dysfunction and degeneration," Mattson continued.
A great, mostly non-technical conversation about science with the wonderful neuroscientist Dr. King-Wai Yau, who has been at Johns Hopkins Medicinefor 32 years.
Live from the neuroscience department of Johns Hopkins Medicine: an interview with neuroscientist Dr. Dwight Bergles on neurons, glial cells, and astrocytes.