For all the latest news from the Solomon H. Snyder Department of Neuroscience
For all the latest news from the Solomon H. Snyder Department of Neuroscience
Why do people make high-risk decisions, even against the odds? Johns Hopkins researchers say bias that develops over time may make people view risk differently. (Image Credit: Jennifer E. Fairman, CMI, FAMI. © 2019, Johns Hopkins University, AAM)
The lab of Professor of Neuroscience James Knierim in the Zanvyl Krieger Mind/Brain Institute published a paper in Science that discovered a new role of the Lateral Entorhinal Cortex (LEC)—one of the gateways of information into the hippocampal memory system. The paper’s lead authors, Cheng Wang and Xiaojing Chen, showed that the LEC encodes experience from a first-person (egocentric) perspective, in contrast to the world-centered (allocentric) coding of place cells, grid cells, and head direction cells. This discovery supports the idea that the LEC conveys information about the sensory content of an organisms’ experience, which the hippocampus binds within the allocentric maps provided by grid cells and place cells to form the basis of an episodic memory of an event within its spatiotemporal context.
Link to article: http://science.sciencemag.org/content/362/6417/945.long
Publications for Primary Faculty Members - October 2018:
Jiang Z, Yue WWS, Chen L, Sheng Y, Yau KW. Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells. Cell. 2018 Oct 18;175(3):652-664.e12. doi: 10.1016/j.cell.2018.08.055.
Ottenheimer D, Richard JM, Janak PH. Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens. Nat Commun. 2018 Oct 19;9(1):4350. doi: 10.1038/s41467-018-06849-z.
Working with rats, researchers have found robust neural activity related to food choice in a previously overlooked part of the brain. The findings, published in the journal Nature Communications, suggest this brain area could be key to developing therapies and treatments to encourage healthy eating.
Congratulations to Dr. King-Wai Yau who was elected to the National Academy of Medicine!
Publications for Primary Faculty Members - September 2018:
Leech KA, Day KA, Roemmich RT, Bastian AJ. Movement and perception recalibrate differently across multiple days of locomotor learning. J Neurophysiol. 2018 Sep 5. doi: 10.1152/jn.00355.2018. [Epub ahead of print]
Rodríguez G, Chakraborty D, Schrode KM, Saha R, Uribe I, Lauer AM, Lee HK. Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice. Cell Rep. 2018 Sep 25;24(13):3433-3440.e4. doi: 10.1016/j.celrep.2018.08.072.
GAMBLING MONKEYS LIKE BIG BETS, STUDY FINDS
Scientists locate area of brain linked to high-risk behavior, a possible step toward improved treatments for destructively risky behaviors in humans
Monkeys who learned how to gamble have helped researchers pinpoint an area of the brain key to one's willingness to make risky decisions.
By studying the genome of a kind of octopus not known for its friendliness toward its peers, then testing its behavioral reaction to a popular mood-altering drug called MDMA or “ecstasy,” scientists say they have found preliminary evidence of an evolutionary link between the social behaviors of the sea creature and humans, species separated by 500 million years on the evolutionary tree.
A summary of the experiments is published Sept. 20 in Current Biology, and if the findings are validated, the researchers say, they may open opportunities for accurately studying the impact of psychiatric drug therapies in many animals distantly related to people.
Dr. Michela Gallagher has been awarded the 2018 Melvin R. Goodes Prize for Excellence in Alzheimer's Drug Discovery. The prize, awarded by the Alzheimer's Drug Discovery Foundation, recognizes leading researchers developing treatments for Alzheimer's disease and related dementias.
Congratulations to Travis Babola and Kevin Monk who were selected as Robert R. Goodman MD PhD Young Scholar Award Winners! This Award honors neuroscience training program students for their impressive contributions to our scientific community.
Congratulations to Mark Lay, Andrew Scasny, Natalie Hamilton, and Christopher Yang for passing their qualifying exams, and officially becoming PhD candidates!
Publications for Primary Faculty Members - August 2018:
Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron. 2018 Aug 8;99(3):511-524.e5. doi: 10.1016/j.neuron.2018.07.004. Epub 2018 Aug 1.
Cherry-Allen KM, Statton MA, Celnik PA, Bastian AJ.A Dual-Learning Paradigm Simultaneously Improves Multiple Features of Gait Post-Stroke. Neurorehabil Neural Repair. 2018 Aug 7:1545968318792623. doi: 10.1177/1545968318792623. [Epub ahead of print]
Chin SG, Maguire SE, Huoviala P, Jefferis GSXE, Potter CJ. Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila. Cell Rep. 2018 Aug 7;24(6):1667-1678. doi: 10.1016/j.celrep.2018.07.018.
Lilley BN, Sabbah S, Hunyara JL, Gribble KD, Al-Khindi T, Xiong J, Wu Z, Berson DM, Kolodkin AL. Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. J Comp Neurol. 2018 Aug 3. doi: 10.1002/cne.24507. [Epub ahead of print]
Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S. Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev Biol. 2018 Jul 29. pii: S0012-1606(18)30451-2. doi: 10.1016/j.ydbio.2018.07.021. [Epub ahead of print]
Saunders BT, Richard JM, Margolis EB, Janak PH. Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. Nat Neurosci. 2018 Aug;21(8):1072-1083. doi: 10.1038/s41593-018-0191-4. Epub 2018 Jul 23.
Sun S, Babola T, Pregernig G, So KS, Nguyen M, Su SM, Palermo AT, Bergles DE, Burns JC, Müller U. Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System. Cell. 2018 Jul 30. pii: S0092-8674(18)30902-4. doi: 10.1016/j.cell.2018.07.008. [Epub ahead of print]
Therrien AS, Wolpert DM, Bastian AJ. Increasing Motor Noise Impairs Reinforcement Learning in Healthy Individuals. eNeuro. 2018 Aug 13;5(3). pii: ENEURO.0050-18.2018. doi: 10.1523/ENEURO.0050-18.2018. eCollection 2018 May-Jun.
Congratulations to Dr. Loyal Goff and Dr. Christopher Potter, Primary faculty members in the Solomon H. Snyder Department of Neuroscience, who were 2 of 32 selected to receive this year's JHU Catalyst Award!
30 years at Johns Hopkins
Friday, 6/22/18, 8:30am – 5pm
Poster Session and Reception to Follow
Congratulations to Dr. Richard Huganir who has been named a Bloomberg Distinguished Professor! Dr. Huganir is the Professor and Director of the Department of Neuroscience, Director of the Kavli Neuroscience Discovery Institute, and Co-Director of the Brain Science Institute.
Publications from Primary Faculty Members - May 2018:
Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A. Two distinct mechanisms for experience-dependent homeostasis. Nat Neurosci. 2018 May 14. doi: 10.1038/s41593-018-0150-0. [Epub ahead of print]
Fu C, Rojas T, Chin AC, Cheng W, Bernstein IA, Albacarys LK, Wright WW, Snyder SH. Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1. Sci Rep. 2018 May 4;8(1):7039. doi: 10.1038/s41598-018-25468-8.
Li RC, Lin CC, Ren X, Wu JS, Molday LL, Molday RS, Yau KW. Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2018 May 7. pii: 201803443. doi: 10.1073/pnas.1803443115. [Epub ahead of print]
Minamisawa G, Kwon SE, Chevée M, Brown SP, O'Connor DH. A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices. Cell Rep. 2018 May 29;23(9):2718-2731.e6. doi: 10.1016/j.celrep.2018.04.115.
Publications from Primary Faculty Members - April 2018:
de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S. Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina. Development. 2018 Apr 12. pii: dev.159970. doi: 10.1242/dev.159970. [Epub ahead of print]
Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandey A, Huganir RL. Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3827-E3836. doi: 10.1073/pnas.1720956115. Epub 2018 Apr 2.
Newman EA, Kim DW, Wan J, Wang J, Qian J, Blackshaw S. Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Apr 18. pii: S0012-1606(17)30906-5. doi: 10.1016/j.ydbio.2018.04.012. [Epub ahead of print]
Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018 Apr 18;9(1):1526. doi: 10.1038/s41467-018-03948-9.
Xie T, Ho MC, Liu Q, Horiuchi W, Lin CC, Task D, Luan H, White BH, Potter CJ, Wu MN. A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep. 2018 Apr 10;23(2):652-665. doi: 10.1016/j.celrep.2018.03.068.
Scientists are trained to be meticulous when they speak about their work. That’s why David Linden likes getting his neuroscience colleagues tipsy. For years, after plying them with spirits, he has been asking brain researchers the same simple question: “What idea about brain function would you most like to explain to the world?” He reports, “I’ve been delighted with their responses. They don’t delve into the minutiae of their latest experiments or lapse into nerd speak. They sit up a little straighter, open their eyes a little wider, and give clear, insightful, and often unpredictable or counterintuitive answers.”
A new book, called THINK TANK, now available from Yale Press, is the result of those conversations. He’s invited a group of the world’s leading neuroscientists, including many from Johns Hopkins, to answer that key question in the form of a short essay.
You can read an excerpt on Amazon here: