For all the latest news from the Solomon H. Snyder Department of Neuroscience
For all the latest news from the Solomon H. Snyder Department of Neuroscience
Publications from Primary Faculty Members - December 2017:
Paul, BD, Snyder, SH. Gasotransmitter Hydrogen Sulfide Signaling in Neuronal Health and Disease. Biochem Pharmacol. 2017 Dec 1. pii: S0006-2952(17)30700-1. doi: 10.1016/j.bcp.2017.11.019. [Epub ahead of print]
Scherer, PC, Zaccor, NW, Neumann, NM, Vasavda, C, Barrow, R, Ewald, AJ, Rao, F, Sumner, CJ, Snyder, SH. TRPV1 is a physiological regulator of μ-opioid receptors. Proc Natl Acad Sci U S A. 2017 Dec 4. pii: 201717005. doi: 10.1073/pnas.1717005114. [Epub ahead of print]
Publications from Primary Faculty Members - November 2017:
Hu, B, Niebur, E. A recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Dec;43(3):227-242. doi: 10.1007/s10827-017-0659-3. Epub 2017 Sep 19.
Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017 Nov 14. pii: S0896-6273(17)31021-8. doi: 10.1016/j.neuron.2017.10.029. [Epub ahead of print]
Three primary Neuroscience faculty were chosen to recieve 2017 Synergy Awards: Dr. Jay Baraban, Dr. Loyal Goff, Dr. Ulrich Mueller. Dr. Mark Wu, secondary in Neuroscience, was chosen to receive a 2017 Innovation Award. Congratulations!
Excerpt from Today Show Interview with Dr. Mark Mattson
"We find that in the animals, the intermittent fasting reduces brain inflammation," said Mark Mattson, chief of laboratory of neurosciences at the National Institute on Aging in Baltimore, Maryland. Mattson also noted that in mice studies, intermittent fasting dramatically improved heart health and prevented the symptoms of Alzheimer's.
"Intermittent fasting improves cognition, that is learning and memory, and protects nerve cells from dysfunction and degeneration," Mattson continued.
A great, mostly non-technical conversation about science with the wonderful neuroscientist Dr. King-Wai Yau, who has been at Johns Hopkins Medicinefor 32 years.
Live from the neuroscience department of Johns Hopkins Medicine: an interview with neuroscientist Dr. Dwight Bergles on neurons, glial cells, and astrocytes.
Publications from Primary Faculty Members - October 2017:
Publications from Primary Faculty Members - September 2017:
Vandaele Y, Pribut HJ, Janak PH. Lever Insertion as a Salient Stimulus Promoting Insensitivity to Outcome Devaluation. Front Integr Neurosci. 2017 Sep 27;11:23. doi: 10.3389/fnint.2017.00023. eCollection 2017.
In recognition of their achievements in graduate studies by successful completion of the Doctoral Board Examination, Neuroscience Training Program Students were recognized at the Annual "Graduate Coating Ceremony" on September 1, 2017 at 4:00 p.m., in Sommer Hall.
Johns Hopkins researchers report the unexpected presence of a type of neuron in the brains of mice that appears to play a central role in promoting sleep by turning ‘off’ wake-promoting neurons. The newly identified brain cells, located in a part of the hypothalamus called the zona incerta, they say, could offer novel drug targets to treat sleep disorders, such as insomnia and narcolepsy, caused by the dysfunction of sleep-regulating neurons.
Publications from Primary Faculty Members - July 2017:
Fraser KM, Janak PH. Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking. Eur J Neurosci. 2017 Jul 12. doi: 10.1111/ejn.13642. [Epub ahead of print]
Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci Rep. 2017 Jul 18;7(1):5685. doi: 10.1038/s41598-017-05864-2.
Congratulations to the the following Neuroscience Department Faculty members for being selected as 2017 Discovery Award winners!
Neuroscientist King-Wai Yau of Johns Hopkins University has made fundamental discoveries concerning the mechanisms underlying sensory transduction. His research over the past four decades has focused primarily on vision. “Vision is one of our most precious senses from which come art, science, humanity, beauty, and practically all aspects of life,” says Yau. His findings concerning phototransduction—the process by which light is converted into a neural signal—have led to a sophisticated understanding of many hereditary diseases causing blindness. Additionally, Yau has elucidated the process of olfaction transduction that, like vision, relies on a G protein-coupled cellular signaling pathway. His Inaugural Article, signifying his 2010 election to the National Academy of Sciences, advances understanding of the electrical response of olfactory neurons to odorants.
Publications from Primary Faculty Members - June 2017:
Harraz MM, Snyder SH. Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb. Neurotherapeutics. 2017 Jun 13. doi: 10.1007/s13311-017-0540-0. [Epub ahead of print]
Jeck DM, Qin M, Egeth H, Niebur E. Attentive pointing in natural scenes correlates with other measures of attention. Vision Res. 2017 Jun;135:54-64. doi: 10.1016/j.visres.2017.04.001. Epub 2017 May 8.
Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr Biol. 2017 Jun 19;27(12):1791-1800.e5. doi: 10.1016/j.cub.2017.05.022. Epub 2017 Jun 1.
Xie X, Tabuchi M, Brown MP, Mitchell SP, Wu MN, Kolodkin AL. The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections. Elife. 2017 Jun 20;6. pii: e25328. doi: 10.7554/eLife.25328. [Epub ahead of print]
In a report in the June 19 issue of the journal Current Biology, Neuroscience Professor King-Wai Yau and colleagues detail how the pupils in a mouse’s eyes get smaller when the animal is moved from a dark to a lit room even when the nerve connections between the animal’s brain and eyes are severed.
Publications from Primary Faculty Members - May 2017:
Cox E, Hwang W, Uzoma I, Hu J, Guzzo CM, Jeong J, Matunis MJ, Qian J, Zhu H, Blackshaw S. Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Mol Cell Proteomics. 2017 May;16(5):812-823. doi: 10.1074/mcp.M116.063719. Epub 2017 Mar 2.
Kajstura TJ, Dougherty SE, Linden DJ. Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury. J Neurosci Res. 2017 May 9. doi: 10.1002/jnr.24059. [Epub ahead of print]
Severson KS, Xu D, Van de Loo M, Bai L, Ginty DD, O'Connor DH. Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents. Neuron. 2017 May 3;94(3):666-676.e9. doi: 10.1016/j.neuron.2017.03.045. Epub 2017 Apr 20.
Congratulations to the following Graduate Student and Postdoc winners of the 2017 Young Inverstigator's Awards!
Scroll down past the list for more information on our award winning Neuroscience members.
Jonathan Grima – Jeff Rothstein’s lab
The Paul Ehrlich Research Award
Mutant Huntingtin Disrupts the Nuclear Pore Complex
Kai Liu – Seth Blackshaw’s lab
The Mette Strand Research Award
Lhx6-Expressing GABAergic Neurons of the Zona Incerta Promote Sleep
Shuohao Sun – Xinzhong Dong’s lab
The Alicia Showalter-Reynolds Research Award
Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch
Graham Diering, PhD - lab of Richard Huganir
The Daniel Nathans Research Award
Homeostatic Scaling of Excitatory Synapses During Sleep
Sung-Eun (Sam) Kwon, PhD – lab of Daniel H. O’Connor
The Albert Lehninger Research Award
Cortical Circuits for Touch Perception
Jonathan Grima, a Neuroscience Graduate Student in Dr. Jeffrey Rothstein's lab, recently reported his research in Neuron regarding a potential cellular cause for neurodegenerative diseases like Huntington's Disease. Jonathan, and his work, were also featured in a recent Baltimore Sun article.