For all the latest news from the Solomon H. Snyder Department of Neuroscience
For all the latest news from the Solomon H. Snyder Department of Neuroscience
Congratulations to our 2019 Neuroscience Ph.D. Graduates we’re so proud of you!
Anna Chang, Jonathan Grima, Wendy Xin, Richard Roth, Travis Babola, Aneesh Donde and Travis Faust
Publications from Primary Faculty members - April 2019:
Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. 2019 Apr 1. doi: 10.1038/s41593-019-0366-7. [Epub ahead of print].
Nardou R, Lewis EM, Rothhaas R, Xu R, Yang A, Boyden E, Dölen G. Oxytocin-dependent reopening of a social reward learning critical period with MDMA. Nature. 2019 Apr 3. doi: 10.1038/s41586-019-1075-9. [Epub ahead of print]
Publications from Primary Faculty members - March 2019:
Chokshi V, Druciak B, Worley PF, Lee HK. Homer1a is required for establishment of contralateral bias and maintenance of ocular dominance in mouse visual cortex. J Neurosci. 2019 Mar 13. pii: 3188-18. doi: 10.1523/JNEUROSCI.3188-18.2019. [Epub ahead of print]
Weyemi U, Paul BD, Bhattacharya D, Malla AP, Boufraqech M, Harraz MM, Bonner WM, Snyder SH. Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7471-7476. doi: 10.1073/pnas.1820245116. Epub 2019 Mar 25.
Dr. Lee will join the Johns Hopkins Department of Neuroscience community in 2019. His laboratory research focus will be to understand brain mechanisms of decision making, in particular the role of the prefrontal cortex and basal ganglia in reinforcement learning and economic choices. His research employs diverse methods developed in economics, psychology, and neuroscience. He is also an expert in statistical modeling of behavioral and neurophysiological data. Dr. Lee received his Ph.D. from the University of Illinois at Urbana-Champaign, and postdoctoral training in neurophysiology at the University of Minnesota. Learn more about more about Dr. Lee’s neuroscience research in his TEDx Talks on “How Genes and the Brain See the World” and the "Brain and Self Intelligence".
Publications from Primary Faculty members - February 2019:
Jayakumar RP, Madhav MS, Savelli F, Blair HT, Cowan NJ, Knierim JJ. Recalibration of path integration in hippocampal place cells. Nature. 2019 Feb 11. doi: 10.1038/s41586-019-0939-3. [Epub ahead of print]
Congratulations to James Knierim whose research on how locations are encoded in the brain was recently published in Nature!
Congratulations to Dr. Richard Huganir who was awarded the 2019 Edward M. Scolnick Prize by the McGovern Institute for his role in understanding the molecular and biochemical underpinnings of synaptic plasticity.
Publications from Primary Faculty members - January 2019:
Andzelm MM, Vanness D, Greenberg ME, Linden DJ. A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2. Cell Rep. 2019 Jan 29;26(5):1089-1097.e3. doi: 10.1016/j.celrep.2019.01.004.
Green DP, Limjunyawong N, Gour N, Pundir P, Dong X. A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain. Neuron. 2019 Feb 6;101(3):412-420.e3. doi: 10.1016/j.neuron.2019.01.012. Epub 2019 Jan 24.
Keiflin R, Pribut HJ, Shah NB, Janak PH. Ventral Tegmental Dopamine Neurons Participate in Reward Identity Predictions. Curr Biol. 2019 Jan 7;29(1):93-103.e3. doi: 10.1016/j.cub.2018.11.050. Epub 2018 Dec 20. Proc Natl Acad Sci U S A. 2019 Jan 7. pii: 201811259. doi: 10.1073/pnas.1811259115. [Epub ahead of print]
Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH, Dong X. Identification of a bilirubin receptor that may mediate a component of cholestatic itch. Elife. 2019 Jan 18;8. pii: e44116. doi: 10.7554/eLife.44116. [Epub ahead of print]
Sacré P, Kerr MSD, Subramanian S, Fitzgerald Z, Kahn K, Johnson MA, Niebur E, Eden UT, González-Martínez JA, Gale JT, Sarma SV. Risk-taking bias in human decision-making is encoded via a right-left brain push-pull system. Proc Natl Acad Sci U S A. 2019 Jan 7. pii: 201811259. doi: 10.1073/pnas.1811259115. [Epub ahead of print]
Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A. The glutathione cycle shapes synaptic glutamate activity. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2701-2706. doi: 10.1073/pnas.1817885116. Epub 2019 Jan 28.
Shah AP, Johnson MD, Fu X, Boersma GJ, Shah M, Wolfgang MJ, Tamashiro KL, Baraban JM. Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance. Int J Obes (Lond). 2019 Jan 15. doi: 10.1038/s41366-018-0315-7. [Epub ahead of print]
Why do people make high-risk decisions, even against the odds? Johns Hopkins researchers say bias that develops over time may make people view risk differently. (Image Credit: Jennifer E. Fairman, CMI, FAMI. © 2019, Johns Hopkins University, AAM)
Publications for Primary Faculty Members - December 2018:
The lab of Professor of Neuroscience James Knierim in the Zanvyl Krieger Mind/Brain Institute published a paper in Science that discovered a new role of the Lateral Entorhinal Cortex (LEC)—one of the gateways of information into the hippocampal memory system. The paper’s lead authors, Cheng Wang and Xiaojing Chen, showed that the LEC encodes experience from a first-person (egocentric) perspective, in contrast to the world-centered (allocentric) coding of place cells, grid cells, and head direction cells. This discovery supports the idea that the LEC conveys information about the sensory content of an organisms’ experience, which the hippocampus binds within the allocentric maps provided by grid cells and place cells to form the basis of an episodic memory of an event within its spatiotemporal context.
Link to article: http://science.sciencemag.org/content/362/6417/945.long
Publications for Primary Faculty Members - October 2018:
Jiang Z, Yue WWS, Chen L, Sheng Y, Yau KW. Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells. Cell. 2018 Oct 18;175(3):652-664.e12. doi: 10.1016/j.cell.2018.08.055.
Ottenheimer D, Richard JM, Janak PH. Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens. Nat Commun. 2018 Oct 19;9(1):4350. doi: 10.1038/s41467-018-06849-z.
Working with rats, researchers have found robust neural activity related to food choice in a previously overlooked part of the brain. The findings, published in the journal Nature Communications, suggest this brain area could be key to developing therapies and treatments to encourage healthy eating.
Congratulations to Dr. King-Wai Yau who was elected to the National Academy of Medicine!
Publications for Primary Faculty Members - September 2018:
Leech KA, Day KA, Roemmich RT, Bastian AJ. Movement and perception recalibrate differently across multiple days of locomotor learning. J Neurophysiol. 2018 Sep 5. doi: 10.1152/jn.00355.2018. [Epub ahead of print]
Rodríguez G, Chakraborty D, Schrode KM, Saha R, Uribe I, Lauer AM, Lee HK. Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice. Cell Rep. 2018 Sep 25;24(13):3433-3440.e4. doi: 10.1016/j.celrep.2018.08.072.
GAMBLING MONKEYS LIKE BIG BETS, STUDY FINDS
Scientists locate area of brain linked to high-risk behavior, a possible step toward improved treatments for destructively risky behaviors in humans
Monkeys who learned how to gamble have helped researchers pinpoint an area of the brain key to one's willingness to make risky decisions.
By studying the genome of a kind of octopus not known for its friendliness toward its peers, then testing its behavioral reaction to a popular mood-altering drug called MDMA or “ecstasy,” scientists say they have found preliminary evidence of an evolutionary link between the social behaviors of the sea creature and humans, species separated by 500 million years on the evolutionary tree.
A summary of the experiments is published Sept. 20 in Current Biology, and if the findings are validated, the researchers say, they may open opportunities for accurately studying the impact of psychiatric drug therapies in many animals distantly related to people.
Dr. Michela Gallagher has been awarded the 2018 Melvin R. Goodes Prize for Excellence in Alzheimer's Drug Discovery. The prize, awarded by the Alzheimer's Drug Discovery Foundation, recognizes leading researchers developing treatments for Alzheimer's disease and related dementias.