Johns Hopkins University, Department of Neuroscience
 

 

 

 

Min  Li, Ph.D

Professor of Neuroscience

Telephone Number:   Office (410) 614-5131

Lab Number:  410-614-3693

Fax Number:  (410) 614-1001

The Solomon H. Snyder Department of Neuroscience

Johns Hopkins University

School of Medicine

725 North Wolfe St.

Baltimore, MD 21205

Room:  319 Broadway Research Building

minli@jhmi.edu


(click on picture for caption)

Signal Transduction in the Mammalian Nervous System; Structure and Function of Cell Surface Proteins

      Our lab has been interested in studying cell surface molecules that mediate signal transduction in the nervous system. One area of our research focuses on the molecular and cellular mechanisms by which potassium channels are assembled and regulated. The native potassium channel complex contains pore-forming subunits, modulatory auxiliary subunits and posttranslational enzymes (i.e., kinases and phosphotases). The combinatorial and regulatory assembly of these diverse proteins has been implicated in neuronal plasticity. We also idenfied and characterize novel compounds that either inhibit or activate potassium channels. Investigation of these chemicals may provide leads for therapeutics. Our long term goal is to understand the macromolecular organization and regulatory network of native ion channel complexes. For more information, visit http://www.molecularinteraction.org

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