Ted Dawson MD, PhD

Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases

Cooper, O., H. Seo, S. Andrabi, C. Guardia-Laguarta, J. Graziotto, M. Sundberg, J.R. McLean, L. Carrillo-Reid, Z. Xie, T. Osborn, G. Hargus, M. Deleidi, T. Lawson, H. Bogetofte, E. Perez-Torres, L. Clark, C. Moskowitz, J. Mazzulli, L. Chen, L. Volpicelli-Daley, N. Romero, H. Jiang, R.J. Uitti, Z. Huang, G. Opala, L.A. Scarffe, V.L. Dawson, C. Klein, J. Feng, O.A. Ross, J.Q. Trojanowski, V.M.-Y. Lee, K. Marder, D.J. Surmeier, Z.K. Wszolek, S. Przedborski1, D. Krainc, T.M. Dawson, O. Isacson. (2012) “Familial Parkinson’s disease iPSCs show cellular deficits in mitochondrial responses that can be pharmacologically rescued.” Science Translational Medicine, in press 2012.

Chi, Z., J. Zhang, A. Tokunaga, A. Dolinko, S. Blackshaw, N. Gaiano, T.M. Dawson and V.L. Dawson. (2012) “Botch promotes neurogenesis by antagonizing Notch.” Development Cell, 2012 Apr 17;  22:707-20. [pdf]

Kang, H.C., Y.-I. Lee, J.-H. Shin, S. Andrabi, Z. Chi, J.-P. Gagne, Y. Lee, H.S. Ko, B.D. Lee, G.G. Poirier, V.L. Dawson, T.M. Dawson. (2011) “Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.” Proc. Natl. Acad. Sci. U.S.A., 2011 Aug 23; 108:14103-14108.  [pdf]

Andrabi, S.A., H.C. Kang, J.-F. Haince, Y.-I. Lee, J. Zhang, Z. Chi, A.B. West, R.C. Koehler, G.G. Poirier, T.M. Dawson and V.L. Dawson (2011) “Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.” Nature Medicine, 2011 Jun; 17:692-699.

Martin, I., V.L. Dawson and T.M. Dawson, (2011) “Recent advances in the genetics of Parkinson's disease.” Annual Review of Genomics and Human Genetics, 2011 Sep 22; 12:301-325.  [pdf]

Zhang. J. Y. Wang, Z. Chi, Y.-M.E. Pai, A. Byugyenko, H. Wang, Y. Xiong, M.V. Pletnikov, M.P. Mattson, T.M. Dawson, Valina L. Dawson (2011) “The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.“ Cell, 2011 Apr 15; 145:284-299.(Cover Article)

Wang, Y., N.S. Kim, J.-F. Haince, H.C.Kang, K.K. David, S. Andrabi, G.G. Poirier, V.L. Dawson and T.M. Dawson. (2011) “Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).” Science Signaling, 2011 Apr 5; 4(167):ra20.  (Cover Article)

Shin, J.-H., H.S. Ko, H.C. Kang, Y. Lee, Y.-I. Lee, O. Pletinkova, J.C. Troncoso, V.L. Dawson and T.M. Dawson. (2011) “PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.” Cell, 2011 Mar 4; 144:689-702.  (Featured Article).

Ko, H.S., Y. Lee, J.-H. Shin, S.S. Karuppagounder, B.S. Gadad, A.J. Koleske, O. Pletnikova, J.C. Troncoso, V.L. Dawson, T.M. Dawson. (2010) “Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.” Proc. Natl. Acad. Sci. U.S.A., 2010 Sep 21; 107:16691-16696.

Lee, B.D., J.H. Shin, J. VanKampen, L. Petrucelli, A. B. West, H.S. Ko, Y.L. Lee, K.A. Maguire-Zeiss, W.J. Bowers, H. Federoff, V.L. Dawson and T.M. Dawson. (2010) “Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.” Nature Medicine, 2010 Sep; 16:998-1000, Epb 2010 Aug 22.

Zheng, S. S.M. Eacker, S.J. Hong, R.M. Gronostajski, T.M. Dawson, V.L. Dawson. (2010) “NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice.” Journal of Clinical Investigation, 2010 Jul; 120:2446-56.

Dawson, T.M., H.S. Ko, V.L. Dawson, (2010)“Genetic animal models of Parkinson's disease. Neuron, 2010 Jun 10;  66:646-61.

Andrabi, S., N.S. Kim, S.W. Yu, H. Wang, D. Koh, M. Sasaki, J.A. Klaus, T. Otsuka, Z. Zhang, R.C. Koehler, P. Hurn, G.G. Poirier, V.L. Dawson and T.M. Dawson. (2006) “Poly(ADP-ribose) (PAR) polymer is a death signal.” Proc. Natl. Acad. Sci. U.S.A., 2006 Nov 28; 103: 18308–18313, Epub 2006 Nov 20.  [PDF]

Chung, K.K.K., B. Thomas, X. Li, O. Pletnikova, J.C. Troncoso, L. Marsh, V. L. Dawson and T.M. Dawson. (2004) “S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.” Science, 2004 May 28; 304:1328-1331, Epub 2004 Apr 22.  [PDF]

Yu, S.-W., H.-M. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, Guy G. Poirer, T.M. Dawson, V.L. Dawson  (2002) “Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science, 2002 Jul 12; 297: 259-263.