Geoffrey Schoenbaum MD, PhD

Branch Chief and Senior Investigator, Tenured Cellular Neurobiology Research Branch Behavioral Neurophysiology

geoffreyschoenbaum@nih.gov
Telephone Number: 443-722-6746

NID-IRP
Neurobiology Research Branch
Behavioral Neurophysiology Research Section
251 Bayview Blvd
Baltimore, MD 21224
Room: Suite 200 Bldg BRC, Room 06A705
Lab Page
Areas of Research
Systems, Cognitive + Computational Neuroscience
Neural Circuits, Ensembles + Connectomes

Graduate Program Affiliations

Neuroscience Training Program

Associative Learning, Decision Making, and Addiction Geoffrey Schoenbaum, MD/PhD

The Schoenbaum Lab is interested in the neural circuits mediating associative learning and decision making and how alterations in those circuits contribute to maladaptive behaviors in neuropsychiatric disorders such as addiction. We use rats as a model system to study behaviors and neural circuits that we believe have direct relevance to understanding the human brain. Areas of particular interest include the orbitofrontal cortex, amygdala, striatum, and midbrain dopamine system. Our lab uses behavioral tasks based on principles derived from learning theory, combined with single unit recording, lesions, pharmacological and genetic manipulations to test hypotheses about how these areas interact to support learning and adaptive behavior.

Our lab uses established and boutique behavioral approaches combined with techniques ranging from single-unit recording to fast scan cyclic voltametry to neurotoxic lesions to optogenetics.

Experiments are designed to test hypotheses regarding the neural instantiation of empirically-derived mechanisms known to govern associative learning and decision making, in both normal and drug-experienced animals.

Our hypotheses are lifted from the rich traditions of animal learning theory, computational neuroscience, and economics.


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