Paul Worley MD

Professor of Neuroscience




For a more complete list of publications, click here.

NEW Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.  Cell. 2011 Oct 28;147(3):615-28. [pdf]

NEW Hu JH, Yang L, Kammermeier P, Moore CG, Brakeman PR, Tu JC, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B and Worley PF. Preso1 dynamically regulates Group1 metabotropic glutamate receptors. Nature Neuroscience. 2012 [pdf]

NEW Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H.  Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ.  Cell. 2012 May 11; 149(4):886-98.[pdf]

Bangash MA, Park JM, Melnikova T, Wang D, Jeon SK, Lee D, Syeda S, Kim J, Kouser M, Schwartz J, Cui Y, Zhao X, Speed HE, Kee SE, Tu JC, Hu JH, Petralia RS, Linden DJ, Powell CM, Savonenko A, Xiao B, Worley PF. Enhanced Polyubiquitination of Shank3 and NMDA receptor in a Mouse Model of Autism.  Cell. 2011 May 27;145(5):758-772.

Chang MC, Park JM, Pelkey KA, Grabenstatter HL, Xu D et al. Narp regulates homeostatic scaling of  excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci. 2010; 13(9):1090-7.

Park, S., Park, JM, Kim, S., Kim, J-A, Shepherd J.D., Smith-Hicks, C.L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A.G., Huganir, R.L., Linden, D.J., and Worley, P.F.  (2008)  Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD.  Neuron  59, 70-83, July 10, 2008. [PDF]

Cho, R.W., Park, J.M., Wolff, S.B.E., Xu, D., Hopf, C., Kim, J.-A., Reddy, R.C., Petralia, R.S., Perin, M.S., Linden, D.J., Worley, P.F. (2008)  mGluR1/5-dependent Long-Term Depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. Neuron Vol. 57(6), 858-871.

Chowdhury S., Shepherd J., Okuno, H., Lyford G., Petralia R., Plath N., Kuhl D., Huganir R.L.,  and Worley, P.F.  (2006)  Arc/Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking.  Neuron, Vol. 52(3):  445-459.  [PDF]

Shepherd, J., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R.L., and Worley, P.F.  (2006)  Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors.  Neuron, Vol. 52(3): 475-484.  [PDF]

Huang, G., Zeng, W., Kim, J.Y., Yuan, J.P., Han, LinHuang, H., Muallem, S., and Worley, P.F.  (2006)  STIML carboxyl-terminus activates native SOC, /crac and TRPC1 channels.  Nature Cell Biology, Vol. 8(9):  1003-1010.   [PDF]

Xu, D., Hopf, C., Reddy, R., Cho, R. W., Guo, L., Lanahan, A., Petralia, R. S., Wenthold, R. J., O'Brien, R. J., and Worley, P. (2003). Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. Neuron 39, 513-528. [PDF]

Yuan, J. P., Kiselyov, K., Shin, D. M., Chen, J., Shcheynikov, N., Kang, S. H., Dehoff, M. H., Schwarz, M. K., Seeburg, P. H., Muallem, S., and Worley, P. F. (2003). Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114, 777-789. [PDF]

Kim, S.J., Kim, Yu Shin, Yuan, J., Petralia, R.S., Worley, P.F., and Linden, D. (2003). Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature Vol. 426(6964): 285-291. [PDF]

Guzowski, J. F., McNaughton, B. L., Barnes, C. A., and Worley, P. F. (1999). Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat Neurosci 2, 1120-1124. [PDF]

Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., and Worley, P. F. (1998). Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21, 717-726. [PDF]