Pete Calabresi MD
Professor of Neurology
Professor of Neurology
Kirby, L., Jin, J., Gonzalez-Cardona, J., Smith, M., Martin, K., Wang, J., … Calabresi, P. A. (2018). Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity. BioRxiv, 461434. https://doi.org/10.1101/461434
Bhargava, P., Fitzgerald, K. C., Venkata, S. L. V., Smith, M. D., Kornberg, M. D., Mowry, E. M., … Calabresi, P. A. (2018). Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes. Annals of Clinical and Translational Neurology. https://doi.org/10.1002/acn3.676
Kornberg, M. D., Bhargava, P., Kim, P. M., Putluri, V., Snowman, A. M., Putluri, N., Calabresi, P. A., Snyder, S. H. (2018). Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. https://doi.org/10.1126/science.aan4665
Kornberg, M. D., Smith, M. D., Shirazi, H. A., Calabresi, P. A., Snyder, S. H., & Kim, P. M. (2018). Bryostatin-1 alleviates experimental multiple sclerosis. Proceedings of the National Academy of Sciences, 201719902. https://doi.org/10.1073/pnas.1719902115
Calabresi, P. A. (2018). Advances in multiple sclerosis: from reduced relapses to remedies. The Lancet Neurology, 17(1), 10–12. http://doi.org/10.1016/S1474-4422(17)30417-9
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018). Multiple Sclerosis. New England Journal of Medicine, 378(2), 169–180. http://doi.org/10.1056/NEJMra1401483
Smith, M. D., Calabresi, P. A., & Bhargava, P. (2017). Dimethyl fumarate treatment alters NK cell function in multiple sclerosis. European Journal of Immunology. http://doi.org/10.1002/eji.201747277
Baxi, E. G., DeBruin, J., Jin, J., Strasburger, H. J., Smith, M. D., Orthmann-Murphy, J. L., … Calabresi, P. A. (2017). Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone-induced demyelination. Glia. http://doi.org/10.1002/glia.23229
Smith, M. D., Martin, K. A., Calabresi, P. A., & Bhargava, P. (2017). Dimethyl fumarate alters B-cell memory and cytokine production in MS patients. Annals of Clinical and Translational Neurology, 4(5), 351–355. http://doi.org/10.1002/acn3.411
Glenn, J. D., Smith, M. D., Xue, P., Chan-Li, Y., Collins, S., Calabresi, P. A., … Whartenby, K. A. (2017). CNS-targeted autoimmunity leads to increased influenza mortality in mice. The Journal of Experimental Medicine, 214(2), jem.20160517. http://doi.org/10.1084/jem.20160517
Orthmann-Murphy, J. L., & Calabresi, P. A. (2017). Therapeutic Application of Monoclonal Antibodies in Multiple Sclerosis. Clinical Pharmacology and Therapeutics, 101(1), 52–64. http://doi.org/10.1002/cpt.547
Schott, J. T., Kirby, L. A., Calabresi, P. A., & Baxi, E. G. (2016). Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning. Journal of Visualized Experiments, (108), 53764. http://doi.org/10.3791/53764
Bhargava, P., & Calabresi, P. A. (2016). Metabolomics in multiple sclerosis. Multiple Sclerosis Journal, 22(4), 451–460. http://doi.org/10.1177/1352458515622827
Sotirchos, E. S., Bhargava, P., Eckstein, C., Van Haren, K., Baynes, M., Ntranos, A., … Calabresi, P. A. (2016). Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. Neurology, 86(4), 382–390. http://doi.org/10.1212/WNL.000000000000231
Grishkan, I. V, Tosi, D. M., Bowman, M. D., Harary, M., Calabresi, P. A., & Gocke, A. R. (2015). Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties. Journal of Immunology (Baltimore, Md. : 1950). http://doi.org/10.4049/jimmunol.1403024
Baxi, E. G., DeBruin, J., Tosi, D. M., Grishkan, I. V., Smith, M. D., Kirby, L. A., … Gocke, A. R. (2015). Transfer of Myelin-Reactive Th17 Cells Impairs Endogenous Remyelination in the Central Nervous System of Cuprizone-Fed Mice. Journal of Neuroscience, 35(22), 8626–8639. http://doi.org/10.1523/JNEUROSCI.3817-14.2015
Bhargava, P., Gocke, A., & Calabresi, P. A. (2015). 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls. Journal of Neuroimmunology, 279, 20–4. http://doi.org/10.1016/j.jneuroim.2014.12.018
Baxi, E. G., Schott, J. T., Fairchild, A. N., Kirby, L. A., Karani, R., Uapinyoying, P., … Calabresi, P. A. (2014). A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation. Glia, 62(9), 1513–29. http://doi.org/10.1002/glia.22697
Ntranos, A., Hall, O., Robinson, D. P., Grishkan, I. V, Schott, J. T., Tosi, D. M., … Gocke, A. R. (2014). FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. Journal of Neuroimmunology, 270(1–2), 13–21. http://doi.org/10.1016/j.jneuroim.2014.03.007
Grishkan, I. V, Fairchild, A. N., Calabresi, P. A., & Gocke, A. R. (2013). 1,25-Dihydroxyvitamin D3 selectively and reversibly impairs T helper-cell CNS localization. Proceedings of the National Academy of Sciences of the United States of America, 110(52), 21101–6. http://doi.org/10.1073/pnas.1306072110
Grishkan, I. V, Ntranos, A., Calabresi, P. A., & Gocke, A. R. Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells. Cellular Immunology, 284(1–2), 68–74. http://doi.org/10.1016/j.cellimm.2013.06.011
Hu, L., Wang, T., Gocke, A. R., Nath, A., Zhang, H., Margolick, J. B., … Calabresi, P. A. (2013). Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes. PloS One, 8(1), e54267. http://doi.org/10.1371/journal.pone.0054267
Gocke, A. R., Lebson, L. A., Grishkan, I. V, Hu, L., Nguyen, H. M., Whartenby, K. A., … Calabresi, P. A. (2012). Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950), 188(12), 5877–86. http://doi.org/10.4049/jimmunol.1103095
Hu, L., Gocke, A. R., Knapp, E., Rosenzweig, J. M., Grishkan, I. V, Baxi, E. G., … Calabresi, P. A. (2012). Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21cip1 signaling. The Journal of Biological Chemistry, 287(2), 1261–8. http://doi.org/10.1074/jbc.M111.296798