Solange Brown MD, PhD

Associate Professor of Neuroscience

Chevée M, Brown SP. The development of local circuits in the neocortex: recent lessons from the mouse visual cortex. Current Opinion in Neurobiology. 2018. 53:103-109. doi:10.1016/j.conb.2018.06.009

Minamisawa G, Kwon SE, Cheveé M, Brown SP, O'Connor DH. A non-canonical feedback circuit for rapid interactions between somatosensory cortices. Cell Reports. 2018. 23:2718-2731. doi:10.1016/j.celrep.2018.04.115

Chevée M, Robertson JD, Cannon GH, Brown SP, Goff LA. Variation in neuronal activity state, axonal projection target and position principally define the transcriptional identity of individual neocortical projection neurons. Cell Reports. 2018. 22:441-455. 

Brown SP, Mathur B, Olsen SR, Luppi PH, Bickford ME, Citri A. New breakthroughs in understanding the role of functional interactions between the neocortex and the claustrum. Journal of Neuroscience. 37:10877-10881. 

Liu K, Kim J, Kim DW, Zhang YS, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham IR, Pachinis V, Hattar S, Song J, Brown SP, Blackshaw S. Lhx6-positive GABAergic neurons of the zona incerta promote sleep. Nature. 2017; 548:582-587. 

Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the excitability of neocortical neurons in a mouse model of amyotrophic lateral sclerosis are not specific to corticospinal neurons and are modulated by advancing disease. Journal of Neuroscience. 2017; 37:9037-9053.

Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang H, Wang J, Bergles DE, Brown SP. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Scientific Reports. 2017; 7:5685 .

Kim J, Matney CJ, Roth RH, Brown SP. Synaptic organization of the neuronal circuits of the claustrum. Journal of Neuroscience. 2016. 36:773-784.

Peters OM, Cabrera GT, Tran H, Gendron TF, McKeon JE, Metterville J, Weiss A, Wightman N, Salameh J, Kim J, Sun H, Boylan KB, Dickson D, Kennedy Z, Lin Z, Zhang YJ, Daughrity L, Jung C, Gao FB, Sapp PC, Horvitz HR, Bosco DA, Brown SP, de Jong P, Petrucelli L, Mueller C, Brown RH. Human C9ORF72hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice. Neuron. 2015. 88:902-909.

Kim J, Matney CJ, Blankenship A, Hestrin S, Brown SP. Layer 6 corticothalamic neurons activate a cortical output layer, layer 5a. Journal of Neuroscience. 2014. 34:9656-9664.

Arroyo S, Bennett C, Aziz D, Brown SP, Hestrin S (2012) Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons. Journal of Neuroscience. 32:3859-3864.

Brown SP, Hestrin S (2009) Cell-type identity: A key to unlocking the function of neocortical circuits. Current Opinion in Neurobiology. 19:415-421.

Brown SP, Hestrin S (2009) Intracortical circuits of pyramidal neurons reflect their long-range axonal targets. Nature.457:1133-1136.

Brown SP, Safo P, Regehr WG (2004) Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels. Journal of Neuroscience. 24:5623-5631.

Brown SP, Brenowitz SD, Regehr WG (2003) Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids. Nature Neuroscience. 10:1048-1057.  

Rockhill RL, Daly FJ, MacNeil MA, Brown SP, Masland RH (2002) The diversity of ganglion cells in a mammalian retina. Journal of Neuroscience. 22:3831-3843.

Brown SP, Masland RH (2001) Spatial scale and cellular substrate of contrast adaptation by retinal ganglion cells. Nature Neuroscience. 4:44-51.

Brown SP, He S, Masland RH (2000) Receptive field microstructure and dendritic geometry of retinal ganglion cells. Neuron. 27:371-383.

Brown SP, Masland RH (1999) Costratitification of a population of bipolar cells with the direction-selective circuitry of the rabbit retina. Journal of Comparative Neurology. 408:97-106.