Erik Snapp PhD

Adjunct Professor of Neuroscience Director of Student and Postdoctoral Programs at Janelia Research Campus




Selected Publications

Lippincott-Schwartz J*, Snapp EL*, and Phair RD. 2018. The development and enhancement of FRAP as a key tool for investigating protein dynamics. Biophys J. 115:1146-1155. *co-corresponding authors. PMC6170817

Kaberniuk A, Mohr MA, Verkhusha V*, and Snapp EL*. 2018. MoxMaple3:  an improved inert photoswitchable protein for super resolution imaging. Sci Rep. 8:14738. *co-corresponding authors. PMC6170497

Chorro L, Suzuki M, Chin SS, Williams TM, Snapp EL, Odagiu L, Labrecque N, and Lauvau G. 2018. Interleukin 2 Modulates thymic-derived regulatory T cell epigenetic landscape. Nat Commun. 9(1):5368. PMC6299086

Anton OM, Peterson ME, Hollander MJ, Dorward DW, Arora G, Traba J, Rajagopalan S, Snapp EL, Garcia KC, Waldmann TA, and Long EO. 2019. Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation. Proc Natl Acad Sci USA. 117(1):522-531. doi: 10.1073/pnas.1911678117

Snapp EL. 2019. How to Design a Chalk Talk- The Million Dollar Sales Pitch. Mol Biol Cell. 30:1575-1577. PMCID PMC6727636.

Lajoie P and Snapp EL. 2020 Size-dependent Secretory Protein Reflux into the Cytosol in Association with Acute Endoplasmic Reticulum Stress. Traffic. 21:419-429. http://dx.doi.org/10.1111/tra.12729

Snapp EL, Hegde R, Francolini M, Lombardo F, Colombo S, Pedrazzini E, Borgese N, and Lippincott-Schwartz J. 2003. Formation of stacked cisternae by low affinity protein interactions. J Cell Biol. 163:257-269. PMCID: PMC2173526.Journal Cover.

Snapp EL, Reinhart G, Bogert B, Lippincott-Schwartz J, and Hegde R. 2004. The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells. J Cell Biol. 164:997-1007. PMCID: PMC2172055.

Snapp EL, Iida, T., Frescas, D., Lippincott-Schwartz, J., and Lilly, M. 2004. The fusome mediates intercellular ER connectivity inDrosophila ovarian cysts. Mol Biol Cell. 15:4512-4521. PMCID: PMC519145 

Snapp EL, Sharma A, Lippincott-Schwartz J, and Hegde RS. 2006. Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells. Proc Natl Acad Sci USA. 103:6536-6541. PMC1458919.

Snapp, EL. 2009. Fluorescent Proteins:  A Cell Biologist's User Guide. Trends Cell Biol. 19:649-55. PMC2784028 

Lai CW, Aronson D, and Snapp EL. 2010. BiP Availability Distinguishes States of Homeostasis and Stress in the Endoplasmic Reticulum of Living Cells. Mol Biol Cell. 21:1909-1921. PMC2883936. 

Lajoie P and Snapp EL. 2010. Formation and toxicity of soluble Huntingtin oligomers in living cells. PLoS ONE. 5:e15245. PMCID: PMC3011017.

Aronson DE, Costantini LM, and Snapp EL. 2011. Superfolder GFP is Fluorescent in Oxidizing Environments when Targeted via the Sec Translocon. Traffic. 12:543-548. PMCID: PMC3079558.

Lajoie P and Snapp EL. 2011. Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant Huntingtin. J Cell Sci. 124:3332-3343. PMCID: PMC3178454.

Lajoie P, Moir R, Willis I, and Snapp EL. 2012. Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells. Mol Biol Cell. 23:955-964. PMCID: PMC3290652.

Costantini LM, Fossati M, Francolini M, Snapp EL. 2012 Assessing the tendency of fluorescent proteins to oligomerize under physiologic conditions. Traffic. 13:643-9. PMC3324619.

Lai C*, Otero J*, Hendershot L, and Snapp EL. 2012. ERdj4 association with the ER membrane and ERAD machinery. J Biol Chem287:7969-7978. PMC3318715. * These two authors contributed equally to this work. 

Costantini LM and Snapp EL. 2013. Fluorescent Proteins in Cellular Organelles:  Serious Pitfalls and Some Solutions. DNA Cell Biol. 32 (11):622-627. PMC3806368. Journal Cover.

Lajoie P, Fazio EN, and Snapp EL. 2014. Approaches to imaging unfolded secretory protein stress in living cells. Endoplasmic Reticulum Stress in Diseases.1:27-39. PMC4238303

Costantini L, Baloban M, Markwardt M, Guo F, Rizzo M, Verkhusha V, and Snapp EL. 2015. A palette of fluorescent proteins optimized for diverse cellular environments. Nat Comm. 9:7670. PMC4499870. Highlighted in Nature Methods 12:810 2015.

Kaberniuk A*, Morano N*, Verkhusha V, and Snapp EL. 2017. MoxDendra2:  an inert photoswitchable protein for oxidizing environments. Chem Comm. 53:2106-2109. * co-first authors. PMC5356486

Snapp EL1*, McCaul N1, Quandte M, Cabartova Z, Bontjer I, Kallgren C, Nilsson I, Land A, von Heijne G, Sanders RW, and Braakman I*. 2017. Structure and topology around the cleavage site turn the HIV-1 gp160 signal peptide into a co-translational signal anchor. *co-corresponding authors. 1co-first authors. Elife. Jul 28;6. pii: e26067. PMC5577925.

Book and Methods Chapters

Costantini LM and Snapp EL. Probing Endoplasmic Reticulum Dynamics using Fluorescence Imaging and Photobleaching Techniques. 2013. Bonifacino, J., Dasso, M., Harford, J., Lippincott-Schwartz, J., Yamada, K. editors. Morgan, K. S. series editor. in Current Protocols in Cell Biology. John Wiley & Sons, Inc. New York. 21.7.1-21.7.29. PMC3920296.

Snapp EL. 2013. Photobleaching Methods to study Golgi Complex Dynamics in Living Cells. Methods for Analysis of Golgi Complex Function, edited by Franck Perez and David Stephens. Methods Cell Biol.118:195-216. PMC4266370.

Weigel, AV and Snapp, EL. Imaging cellular proteins and structures. In: MD, IMA, Harvey J. Alter MD, M, MD, JLB, David E. Cohen MD, P, MD, DAS, Snorri S. Thorgeirsson MD, P, et al., editors. The Liver : Biology and Pathology. 6th ed 2020. p. 965-78.

Snapp EL, Altan N, and Lippincott-Schwartz J. 2003. Measuring protein mobility by photobleaching GFP-chimeras in living cells. Unit 21.1: Bonifacino, J., Dasso, M., Harford, J., Lippincott-Schwartz, J., Yamada, K. editors. Morgan, K. S. series editor. in Current Protocols in Cell Biology. John Wiley & Sons, Inc. New York. 

Snapp EL. 2005. Design and Use of Fluorescent Fusion Proteins in Cell Biology. Unit 21.4. Bonifacino, J., Dasso, M., Harford, J., Lippincott-Schwartz, J., Yamada, K. editors. Morgan, K. S. series editor. In Current Protocols in Cell Biology. John Wiley & Sons, Inc. New York. PMCID: PMC2875081

Lajoie P and Snapp EL. 2010. Imaging of membrane systems and membrane traffic in living cells. eds. Goldman, R. and Spector, D. Live Cell Imaging: A Laboratory Manual. Second Edition. Cold Spring Harbor Press. Cold Spring Harbor, NY.

Lajoie P and Snapp EL. 2013. Detecting Soluble polyQ Oligomers and Investigating Their Impacts on Living Cells Using Split-GFP. eds Hatters DM and Hannan AJ. Tandem Repeats in Genes, Proteins, and Disease:  Methods and Protocols (Methods in Molecular Biology). Humana Press. 1017:229-239. PMC4112564