David Linden PhD

Professor of Neuroscience
Director of the Neuroscience Masters Program
Co-Director, Neuroscience Training Program




Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury. Cooke P, Linden DJ. eNeuro. 2025 Jan 10;12(1):ENEURO.0418-24.2024. doi: 10.1523/ENEURO.0418-24.2024. Print 2025 Jan.

Chronic Aromatase Inhibition Attenuates Synaptic Plasticity in Ovariectomized Mice. Brill J, Linden DJ. eNeuro. 2024 Nov 26;11(11):ENEURO.0346-24.2024. doi: 10.1523/ENEURO.0346-24.2024. Print 2024 Nov.

The lateral habenula is required for maternal behavior in the mouse dam. Benedict J, Cudmore RH, Oden D, Spruell A, Linden DJ. eNeuro. 2025 Jan 13;12(1):ENEURO.0092-24.2024. doi: 10.1523/ENEURO.0092-24.2024. Print 2025 Jan.
 
Chronic Treatment with Serotonin Selective Reuptake Inhibitors Does Not Affect Regrowth of Serotonin Axons Following Amphetamine Injury in the Mouse Forebrain.  Janowitz HN, Linden DJ. eNeuro. 2024 Feb 14;11(2):ENEURO.0444-22.2023. doi: 10.1523/ENEURO.0444-22.2023. Print 2024 Feb.PMID: 38355299 
 
Catecholaminergic axons in the neocortex of adult mice regrow following brain injury.  Dougherty SE, Kajstura TJ, Jin Y, Chan-Cortés MH, Kota A, Linden DJ.Exp Neurol. 2020 Jan;323:113089. doi: 10.1016/j.expneurol.2019.113089. Epub 2019 Nov 4.PMID: 31697941 
 
Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.  Zhang W, Chuang YA, Na Y, Ye Z, Yang L, Lin R, Zhou J, Wu J, Qiu J, Savonenko A, Leahy DJ, Huganir R, Linden DJ, Worley PF.Mol Cell. 2019 Jul 11;75(1):13-25.e5. doi: 10.1016/j.molcel.2019.05.004. Epub 2019 May 28.PMID: 31151856 
 
Estrogen-Dependent Functional Spine Dynamics in Neocortical Pyramidal Neurons of the Mouse. Ye Z, Cudmore RH, Linden DJ.J Neurosci. 2019 Jun 19;39(25):4874-4888. doi: 10.1523/JNEUROSCI.2772-18.2019. Epub 2019 Apr 16.PMID: 30992373 
 
A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2. Andzelm MM, Vanness D, Greenberg ME, Linden DJ.Cell Rep. 2019 Jan 29;26(5):1089-1097.e3. doi: 10.1016/j.celrep.2019.01.004.PMID: 30699340 
 
STIM1 Regulates Somatic Ca2+ Signals and Intrinsic Firing Properties of Cerebellar Purkinje Neurons.  Ryu C, Jang DC, Jung D, Kim YG, Shim HG, Ryu HH, Lee YS, Linden DJ, Worley PF, Kim SJ.J Neurosci. 2017 Sep 13;37(37):8876-8894. doi: 10.1523/JNEUROSCI.3973-16.2017. Epub 2017 Aug 11.PMID: 28821659 
 
Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury. Kajstura TJ, Dougherty SE, Linden DJ.J Neurosci Res. 2018 Apr;96(4):512-526. doi: 10.1002/jnr.24059. Epub 2017 May 9.PMID: 28485037 
  
Cerebral vascular structure in the motor cortex of adult mice is stable and is not altered by voluntary exercise. Cudmore RH, Dougherty SE, Linden DJ.J Cereb Blood Flow Metab. 2017 Dec;37(12):3725-3743. doi: 10.1177/0271678X16682508. Epub 2017 Jan 6.PMID: 28059584 
 
Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury.  Jin Y, Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ.Neuron. 2016 Aug 17;91(4):748-762. doi: 10.1016/j.neuron.2016.07.024. Epub 2016 Aug 4.PMID: 27499084 
 
Chronic In Vivo Imaging of Ponto-Cerebellar Mossy Fibers Reveals Morphological Stability during Whisker Sensory Manipulation in the Adult Rat.  Rylkova D, Crank AR, Linden DJ.eNeuro. 2015 Oct 22;2(6):ENEURO.0075-15.2015. doi: 10.1523/ENEURO.0075-15.2015. eCollection 2015 Nov-Dec.PMID: 26693178 
 
Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Zhang Y, Cudmore RH, Lin DT, Linden DJ, Huganir RL.Nat Neurosci. 2015 Mar;18(3):402-7. doi: 10.1038/nn.3936. Epub 2015 Feb 2.PMID: 25643295