Associate Professor of Neurology and Neuroscience; Director, Johns Hopkins Internship in Brain Sciences Program
Brown A. Osteopontin: a key link between immunity, inflammation and the central nervous system. Translational Neuroscience 2012; 3(3): 288-293.
Eger C, Cirelli K, Budiaman J, Brown A. Non-continguous protein interaction domains in osteopontin contribute to enhance HIV-1 replication. J. Human Virol. and Retrovirol 2014; 1(1):00003. DOI: 10.15406/jhvrv.2014.01.00003
Silva K., Hope-Lucas C, White T, Hariston T, Rameau T, Brown A. Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders (HAND). J. Neurovirology 2015; 21(2):174-185.
Brown A. Understanding the MIND phenotype: macrophage/microglial inflammation in neurocognitive disorders related to human immunodeficiency virus infection. Clinical Translational Medicine 2015: 4:7 DOI 10.1186/s40169-015-0049-2.
Saylor D, Dickens A, Sacktor N, Haughey N, Slusher B, Pletnikov M, Brown A, Volsky D, and McArthur J. HIV-associated neurocognitive disorders: emerging concepts in pathogenesis and therapy. Nature Reviews Neurol 2016;12(4):234-248.
Calvez M, Hseeh G, Benzer S, and Brown A. Osteopontin counters HIV-induced neuronal injury through the activation of mTOR and beta-integrin signaling. J. Neurovirology 2019; 25(3):384-396. DOI : 10.1007/s13365-019-00729-yNJIV-D-18-00140.1
Mohamed M, Skolasky RL, Zhou Y, Ye W, Brasic JR, Brown AM, Pardo CA, Barker PB, Wong DF, and N Sacktor. Beta-amyloid (Abeta) uptake by PET imaging in older HIV+ and HIV- individuals. J. Neurovirology 2020; https://doi.org/10.1007/s13365-020-00836-1.
Mahmud F, Boucher T, Liang SJ, and Brown AM.Osteopontin and integrin mediated modulation of post-synapses in HIV envelope glycoprotein exposed hippocampal neurons. Brain Sciences2020; 10(6):346 https://doi.org/10.3390/brainsci10060346. PMID: 32512754
Mahmud F, Du Y, Greif E, Boucher T, DannalsRF, MathewsWB, PomperMG, Sysa-ShahP, Metcalf PateKA, LyonsC, CarlsonB, Chacona M, and Brown AM. Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection. J. Neuroinflammation. 17: 273 2020 doi: 10.1186/s12974-020-01949-4.
Mahmud F, Du Y, Greif E, Boucher T, Metcalf PateKA, LyonsC, CarlsonB, and Brown AM. Complex interactions between human immunodeficiency virus type-1, sex, and osteopontin influence viral and leukocyte persistence in tissues. F. Virology 2021https://doi.org/10.3389/fviro.2021.690360
Boucher T, Liang SJ, and Brown AM. Advancing Basic and Translational Research to Deepen Understanding of the Molecular Immune-Mediated Mechanisms Regulating Long-Term Persistence of HIV-1 in Microglia in the Adult Human Brain. J Leukocyte Biol. 2022; 112:1223-1231.
Yim A, Smith C, Chacona M, and Brown AM. Osteopontin/secreted phosphoprotein-1: a homeostatic sensor and regulator at the neuro-immune axes. Immunological Reviews 2022.http://doi.org/10.1111/imr.13081
Robinson JA, Mahmud FJ, Greif E, Toribio M, Zanni MV, Brown AM and TH Burdo.Osteopontin (OPN) is an Integral mediator of interstitial fibrosis in models of HIV infection. Journal of Infectious Disease 2023:122-132.
Argandona CL and Brown AM. Microglial- neuronal crosstalk in chronic viral infection through mTOR, SPP1/OPN and inflammasome pathway signaling. Front. Immunol. 2024; 15:https://doi.org/10.3389/fimmu.2024.1368465
Sun M, Loganathan S, Argandona Lopez C, Wangui J, Shirmamedova A, Johnson A, Louie P, Pelland Z, Alize-Hunt R, Zhu X, Smith D, and Brown AM. Systemic knockdown of osteopontin/secreted phosphoprotein-1 reverses HIV-1 infection related cognitive impairment 2025. Revision and resubmission in progress.
Davis E, Wangui J, Argandona Lopez, C, Shirmamedova A, and Brown AM.Sex-dependent effects of osteopontin/secreted phosphoprotein-1 on antiretroviral treatment-associated weight change in a model of chronic neuroinflammation 2025. Submission in progress.