Patrick Kanold PhD

Professor of Biomedical Engineering and Neuroscience


71. T. Ribeiro, S. Yu. D. Martin, D. Winkowski, P.O. Kanold, D. Chialvo, D. Plenz, “Trial-by-trial variability in cortical responses exhibits scaling in spatial correlations predicted from critical dynamics”, preprint in bioRxiv
70. X. Meng, B.C Borges, P. Long, P. O. Kanold$, G. Corfas$ “Hypomyelination leads to alterations in inhibitory function and parvalbumin-positive neuron density in the auditory cortex”, preprint in bioRxiv
69. X. Meng, Y. Yu, J.P-Y Kao, P. O. Kanold, “Transient coupling between subplate and subgranular layers to
L1 neurons before and during the critical period”, preprint in bioRxiv
68. Bowen Z, Winkowski DE, , Kanold PO*. Functional Organization of Mouse Primary Auditory Cortex in adult C57/BL6 and F1 (CBAxC57) mice. Scientific Reports 2020, preprint in bioRxiv 2019
67. B. Alipio, A.T. Brockett, M.E. Fox, S.S. Tennyson, C.A. deBrettencourt, D. El-Metwally, N.A.Francis, P. O. Kanold, M.K. Lobo, M.R. Roesch, A.Keller, “Enduring Consequences of perinatal fentanyl exposure in mice”, Addition Biology 2020, bioRxiv 2019
66. S. Murase, D.E. Winkowski, J.Liu, P. O. Kanold, E.M. Quinlan*, “Homeostatic regulation of perisynaptic MMP9 activity in the amblyopic visual cortex. “, eLife 2020, bioRxiv 2019
65. Aghayee S, Kanold P, Losert W*. Novel strategies for holographic optical activation of neurons. Bulletin of the American Physical Society 2019.
64. Sheikh A, Meng X, Liu J, Mikhailova A, Kao JPY, McQuillen PS, Kanold PO*. Neonatal Hypoxia-Ischemia Causes Functional Circuit Changes in Subplate Neurons. Cereb Cortex 2019 Feb 1;29(2):765-76.
63. Liu J, Whiteway MR, Sheikhattar A, Butts DA, Babadi B, Kanold PO* Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits. Cell Rep. 2019 Apr 16;27(3):872-885.e7
62. Bowen Z, Winkowski DE, Seshradi S, Plenz D, Kanold PO*. Neuronal Avalanches in Input and Associative Layers of Auditory Cortex. Front. Syst. Neurosci., 04 September 2019
61. Francis NA, Bohlke K, Kanold PO*. Automated Behavioral Experiments in Mice Reveal Periodic Cycles of Task Engagement within Circadian Rhythms. eNeuro. 2019 Sep 5. pii: ENEURO.0121-19.2019.
60. Meng X, Solarana K, Bowen Z, Liu J, Nagode D, Sheikh A, Kao JPY, Kanold PO*. Transient Subgranular Hyperconnectivity to L2/3 and Enhanced Pairwise Correlation During the Critical Period in the Auditry Cortex. Cerebral Cortex Oct. 30 2019
59. Solarana K, Liu J, Bowen Z, Lee HK, Kanold PO*. Temporary visual deprivation causes decorrelation of spatio-temporal population responses in adult mouse auditory cortex”. eNeuro 2019
58. Aghayee S, Kanold P, Losert W*. Developing new experimental techniques to understand neuronal networks. Bulletin of the American Physical Society 2018.
57. Aghayee S, Kanold P, Losert W*. Reliable targeting method for in vivo photo-stimulation of neurons. Bulletin of the American Physical Society 2018.
56. Francis NA, Winkowski DE, Sheikhattar A, Armengol K, Babadi B, Kanold PO*. Small Networks Encode Decision-Making in Primary Auditory Cortex. Neuron 2018 Feb 21;97(4):885-97 e6.
55. Henschke JU, Oelschlegel AM, Angenstein F, Ohl FW, Goldschmidt J, Kanold PO, Budinger E*. Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices. Brain Struct Funct 2018 Apr;223(3):1165-90.
54. Hoerder-Suabedissen A, Hayashi S, Upton L, Nolan Z, Casas-Torremocha D, Grant E, Viswanathan S, Clasca F, Kim Y, Kanold PO, Molnar Z*. Subset of Cortical Layer 6b Neurons Selectively Innervates Higher Order Thalamic Nuclei in Mice. Cereb Cortex 2018 May 1;28(5):1882-97.
53. Kazemipour A, Liu J, Solarana K, Nagode DA, Kanold PO, Wu M, Babadi B*. Fast and Stable Signal Deconvolution via Compressible State-Space Models. IEEE Trans Biomed Eng 2018 Jan;65(1):74-86.
52. Seshadri S, Klaus A, Winkowski DE, Kanold PO, Plenz D*. Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment. Transl Psychiatry 2018 Jan 10;8(1):3.
51. Sheikhattar A, Miran S, Liu J, Fritz JB, Shamma SA, Kanold PO, Babadi B*. Extracting neuronal functional network dynamics via adaptive Granger causality analysis. Proc Natl Acad Sci U S A 2018 Apr 24;115(17):E3869-E78.
50. Winkowski DE, Nagode DA, Donaldson KJ, Yin P, Shamma SA, Fritz JB, Kanold PO*. Orbitofrontal Cortex Neurons Respond to Sound and Activate Primary Auditory Cortex Neurons. Cereb Cortex 2018 Mar 1;28(3):868-79.
49. Aghayee S, Winkowski DE, Bowen Z, Marshall EE, Harrington MJ, Kanold PO, Losert W*. Particle Tracking Facilitates Real Time Capable Motion Correction in 2D or 3D Two-Photon Imaging of Neuronal Activity. Front Neural Circuits 2017;11:56.
48. Deng R, Kao JPY, Kanold PO*. Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex. Cell Rep 2017 May 9;19(6):1141-50.
47. Francis NA, Kanold PO*. Automated Operant Conditioning in the Mouse Home Cage. Front Neural Circuits 2017;11:10.
46. Meng X, Kao JP, Lee HK, Kanold PO*. Intracortical Circuits in Thalamorecipient Layers of Auditory Cortex Refine after Visual Deprivation. eNeuro 2017 Mar-Apr;4(2).
45. Meng X, Winkowski DE, Kao JPY, Kanold PO*. Sublaminar Subdivision of Mouse Auditory Cortex Layer 2/3 Based on Functional Translaminar Connections. J Neurosci 2017 Oct 18;37(42):10200-14.
44. Nagode DA, Meng X, Winkowski DE, Smith E, Khan-Tareen H, Kareddy V, Kao JPY, Kanold PO*. Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder. Cell Rep 2017 Jan 31;18(5):1100-8.
43. Viswanathan S, Sheikh A, Looger LL, Kanold PO*. Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus. Cereb Cortex 2017 Oct 1;27(10):4759-68.
42. Wess JM, Isaiah A, Watkins PV, Kanold PO*. Subplate neurons are the first cortical neurons to respond to sensory stimuli. Proc Natl Acad Sci U S A 2017 Nov 21;114(47):12602-7.
41. Kazemipour A, Liu J, Kanold P, Wu M, Babadi B*. Efficient Estimation of Compressible State-Space Models with Application to Calcium Signal Deconvolution. 2016 IEEE Global Conference on Signal and Information Processing (GlobalSIP) 2016.
40. Kramida G, Aloimonos Y, Parameshwara C, Fermüller C, Francis N, Kanold P*. Automated Mouse Behavior Recognition using VGG Features and LSTM Networks. Visual observation and analysis of Vertebrate and Insect Behavior VAIB 2016.
39. Mordel J, Sheikh A, Tsohataridis S, Kanold PO, Zehendner CM, Luhmann HJ*. Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex. Neurobiol Dis 2016 Apr;88:29-43.
38. Muralidharan S, Dirda ND, Katz EJ, Tang CM, Bandyopadhyay S, Kanold PO, Kao JPY* Ncm, a Photolabile Group for Preparation of Caged Molecules: Synthesis and Biological Application. PLoS One 2016;11(10):e0163937.
37. Aghayee S, Winkowski D, Kanold P, Losert W*. Multi-point optical manipulation and simultaneous imaging of neural circuits through wavefront phase modulation. Proc SPIE 9548, Optical Trapping and Optical Micromanipulation XII 2015.
36. Meng X, Kao JP, Lee HK, Kanold PO*. Visual Deprivation Causes Refinement of Intracortical Circuits in the Auditory Cortex. Cell Rep 2015 Aug 11;12(6):955-64.
35. Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, Lee HK*. Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices. J Neurosci 2015 Jun 10;35(23):8790-801.
34. Meng X, Kao JP, Kanold PO*. Differential signaling to subplate neurons by spatially specific silent synapses in developing auditory cortex. J Neurosci 2014 Jun 25;34(26):8855-64.
33. Petrus E$, Isaiah A$, Jones AP, Li D, Wang H, Lee HK, Kanold PO*. Crossmodal induction of thalamocortical potentiation leads to enhanced information processing in the auditory cortex. Neuron 2014 Feb 5;81(3):664-73.
32. Watkins PV, Kao JP, Kanold PO*. Spatial pattern of intra-laminar connectivity in supragranular mouse auditory cortex. Front Neural Circuits 2014;8:15.
31. Winkowski DE, Bandyopadhyay S, Shamma SA, Kanold PO*. Frontal cortex activation causes rapid plasticity of auditory cortical processing. J Neurosci 2013 Nov 13;33(46):18134-48.
30. Winkowski DE, Kanold PO*. Laminar transformation of frequency organization in auditory cortex. J Neurosci 2013 Jan 23;33(4):1498-508.
29. Helmy MM, Ruusuvuori E, Watkins PV, Voipio J, Kanold PO, Kaila K*. Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia. Brain 2012 Nov;135(Pt 11):3311-9.
28. Tolner EA$, Sheikh A$, Yukin AY, Kaila K, Kanold PO*. Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. J Neurosci 2012 Jan 11;32(2):692-702. $Co-first author
27. Viswanathan S, Bandyopadhyay S, Kao JP, Kanold PO*. Changing microcircuits in the subplate of the developing cortex. J Neurosci 2012 Feb 1;32(5):1589-601.
26. He K, Lee A, Song L, Kanold PO, Lee HK. AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression. J Neurophysiol 2011 Apr;105(4):1897-907.
25. Kanold PO, Davis KA, Young ED*. Somatosensory context alters auditory responses in the cochlear nucleus. J Neurophysiol 2011 Mar;105(3):1063-70.
24. Postma F$, Liu CH$, Dietsche C, Khan M, Lee HK, Paul D, Kanold PO*. Electrical synapses formed by connexin36 regulate inhibition- and experience-dependent plasticity. Proc Natl Acad Sci U S A 2011 Aug 16;108(33):13770-5.
23. Bandyopadhyay S, Shamma SA, Kanold PO. Dichotomy of functional organization in the mouse auditory cortex. Nat Neurosci 2010 Mar;13(3):361-8.
22. Clancy B*, Defelipe *J, Espinosa A*, Fairen A*, Jinno S*, Kanold P*, Luhmann HJ*, Rockland KS*, Tamamaki N*, Yan XX*. Cortical GABAergic Neurons: Stretching it Remarks, Main Conclusions and Discussion. Front Neuroanat 2010;4:7.{RA]
21. Datwani A, McConnell MJ, Kanold PO, Micheva KD, Busse B, Shamloo M, Smith SJ, Shatz CJ*. Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity. Neuron 2009 Nov 25;64(4):463-70.
20. Kanold PO, Kim YA, GrandPre T, Shatz CJ. Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice. J Physiol 2009 Jun 15;587(Pt 12):2857-67.
19. Zhao C, Kao JP, Kanold PO. Functional excitatory microcircuits in neonatal cortex connect thalamus and layer 4. J Neurosci 2009 Dec 9;29(49):15479-88.
18. Butts DA, Kanold PO, Shatz CJ*. A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. PLoS Biol 2007 Mar;5(3):e61.
17. Cassady A, Denham S, Kanold P, Andreou A*. FPGA Based Silicon Spiking Neural Array. IEEE BioCAS 2007, Biomedical Circuits and Systems Conference; Montreal, Canada 2007.
16. Kanold PO, Shatz CJ*. Subplate neurons regulate maturation of cortical inhibition and outcome of ocular dominance plasticity. Neuron 2006 Sep 7;51(5):627-38.
15. Syken J, Grandpre T, Kanold PO, Shatz CJ*. PirB restricts ocular-dominance plasticity in visual cortex. Science 2006 Sep 22;313(5794):1795-800.
14. Atzori M*, Kanold PO, Pineda JC, Flores-Hernandez J, Paz RD. Dopamine prevents muscarinic-induced decrease of glutamate release in the auditory cortex. Neuroscience 2005;134(4):1153-65.
13. Kanold PO, Manis PB*. Encoding the timing of inhibitory inputs. J Neurophysiol 2005 May;93(5):2887-97.
12. Tagawa Y$, Kanold PO$, Majdan M, Shatz CJ*. Multiple periods of functional ocular dominance plasticity in mouse visual cortex. Nat Neurosci 2005 Mar;8(3):380-8. $ indicates Co-first author
11. Kanold PO. * Transient microcircuits formed by subplate neurons and their role in functional development of thalamocortical connections. Neuroreport 2004 Oct 5;15(14):2149-53.
10. Atzori M*, Kanold P, Pineda JC, Flores-Hernandez J. Dopamine-acetylcholine interactions in the modulation of glutamate release. Ann N Y Acad Sci 2003 Nov;1003:346-8.
9. Kanold PO, Kara P, Reid RC, Shatz CJ*. Role of subplate neurons in functional maturation of visual cortical columns. Science 2003 Jul 25;301(5632):521-5.
8. Atzori M, Lei S, Evans DI, Kanold PO, Phillips-Tansey E, McIntyre O, McBain CJ*. Differential synaptic processing separates stationary from transient inputs to the auditory cortex. Nat Neurosci 2001 Dec;4(12):1230-7.
7. Kanold PO, Manis PB*. A physiologically based model of discharge pattern regulation by transient K+ currents in cochlear nucleus pyramidal cells. J Neurophysiol 2001 Feb;85(2):523-38.
6. Kanold PO, Young ED*. Proprioceptive information from the pinna provides somatosensory input to cat dorsal cochlear nucleus. J Neurosci 2001 Oct 1;21(19):7848-58.
5. Kanold PO, Manis PB*. Transient potassium currents regulate the discharge patterns of dorsal cochlear nucleus pyramidal cells. J Neurosci 1999 Mar 15;19(6):2195-208.
4. Kanold P, Block M, Selinger T, Talmi M*, Yan W, Zhang W. Test and Monitoring of an HDTV MPEG-2 Video Decoder using the TMS320C40. Proceedings of The International Conference on Signal Processing Applications & Technology Dallas 1994.
3. Selinger T, Block M, Kanold P, Talmi M*, Yan W, Zhang W, Zieger M. A Chipset for a Single Board MPEG-2 SSP@H-1440L HDTV-Decoder. International Workshop on HDTV; Oct. 1994; Turino 1994.
2. Talmi M*, Block M, Kanold P, Selinger T, Yan W, Zhang W, Zieger M. Very large scale integration (VLSI) realization of a hierarchical MPEG-2 TV&HDTV decoder. Proceedings Visual Communications and Image Processing SPIE 1994. p. 1734-41.
1. Yao S*, Kanold P. An Efficient Placement Tool for Gate Array Layout. ASICON; Beijing 1994.

Peer reviewed review articles
RA6 Kanold P*. The first cortical circuits: Subplate neurons lead the way and shape cortical organization. Neuroforum 2019.
RA5. Kanold PO*, Deng R, Meng X.. The Integrative Function of Silent Synapses on Subplate Neurons in Cortical
Development and Dysfunction. Front Neuroanat. 2019 Apr 16;13:41.
RA4. Kanold PO$, Nelken I$, Polley DB$. Local versus global scales of organization in auditory cortex. Trends Neurosci 2014 Sep;37(9):502-10.
RA3. Butts DA, Kanold PO. The applicability of spike time dependent plasticity to development. Front Synaptic Neurosci 2010;2:30.
RA2. Kanold PO, Luhmann HJ. The subplate and early cortical circuits. Annu Rev Neurosci 2010;33:23-48.
RA1. Kanold PO*. Subplate neurons: crucial regulators of cortical development and plasticity. Front Neuroanat 2009;3:16.

Book chapters
BC4. Kanold P, Goodrich L. Functional Circuit Development in the Auditory System. In: Rubenstein J. & Rakic P. editors. Comprehensive Developmental Neuroscience 2nd Ed. Elsevier; 2020.
BC3. Kanold P, Budinger E. Auditory Cortex Circuits. In: Oliver D, Cant N, editors. The Mammalian Auditory Pathways: Springer; 2018. p. 199-233.
BC2. Kanold P, Young E, Manis P. Auditory-somatosensory interactions in the dorsal cochlear nucleus. In: Houtsma A, Kohlrausch A, Prijs V, Schoonhoven R, editors. Psychophysical and Physiological Bases of Auditory Function: Shaker; 2000. p. 190-6.
BC1. Manis P, Kanold P, Molitor S. Cellular physiology of pyramidal and cartwheel cells of the dorsal cochlear nucleus. In: Palmer A, Rees A, Summerfield A, Meddis R, editors. Psychophysical and Physiological Adv in Hearing. London: Whurr; 1998. p. 221-7.

ED2. Schreiner C, Kanold P, Ojima H, Shamma S, Lomber S. Auditory Cortical Function: Insights from Current Approaches. Acoustics Today. 2012:42-50.
ED1. Kanold P. Subplate neurons and functional maturation of thalamocortical synapses. ATS Bio. 2003.