Bindu Paul PhD

Associate Professor of Pharmacology, Psychiatry and Neuroscience




Selected Publications

  1. Figueiredo A, Rastogi ST, Ramos S, Nogueira F, De Villiers K, de Sousa AGG, Votborg-Novél L, von Wedel C, Tober-Lau P, Jentho E, Pagnotta S, Mesquita M, Cardoso S, Bortolussi G, Muro AF, Tranfield EM, Thibaud J, Duarte D, Sousa AL, Pinto SN, Kitoko J, Mombo-Ngoma G, Mischlinger J, Junttila S, Alenquer M, Amorim MJ, Vasavda C, Bosma PJ, Violante S, Drotleff B, Paixão T, Portugal S, Kurth F, Elo LL, Paul BD, Martins R, Soares MP.  A metabolite-based resistance mechanism against malaria Science 2025 Jun 12;388(6752):eadq6741. PMID: 40504905.
  2. Vasavda C, Kothari R, Kaidery NA, Chakraborty S, Tripathi SJ, Dhindsa RS, Saberi S, Lefler JE, Kothari P, Chaubey K, Snowman AM, Ostrowski MC, Barone E, Iyer LM, Aravind L, Sharma SM, Pieper AA, Thomas B, Snyder SH, Paul BD. Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling. bioRxiv [Preprint]. 2025 Jun 8:2025.06.04.657936. doi: 10.1101/2025.06.04.657936.PMID: 40502201
  3. Hushpulian DM, Kaidery NA, Soni P, Poloznikov AA, Zakhariants AA, Razumovskaya AV, Silkina MO, Tishkov VI, Kazakov EH, Brown AM, Gaisina IN, Ahn YH, Kazakov SV, Krucher N, Sharma SM, Paul BD, Gazaryan IG, Nikulin SV, Thomas B. Functional analysis of bipartite nrf2 activators that overcome feedback regulation for age-related chronic diseases. bioRxiv [Preprint]. 2025 May 31:2025.05.30.656434. doi: 10.1101/2025.05.30.656434.PMID: 40501562 
  4. Koh Y, Vázquez-Rosa E, Gao F, Li H, Chakraborty S, Tripathi SJ, Barker S, Bud Z, Bangalore A, Kandjoze UP, León-Alvarado RA, Sridharan PS, Cordova BA, Yu Y, Hyung J, Fang H, Singh S, Katabathula R, LaFramboise T, Kasturi L, Lutterbaugh J, Beard L, Cordova E, Cintrón-Pérez CJ, Franke K, Fragoso MF, Miller E, Indrakumar V, Noel KL, Dhar M, Ajroud K, Zamudio C, Lopes FBTP, Bambakidis E, Zhu X, Wilson B, Flanagan ME, Gefen T, Fujioka H, Fink SP, Desai AB, Dawson D, Williams NS, Kim YK, Ready JM, Paul BD, Shin MK, Markowitz SD, Pieper AA. Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury. Proc Natl Acad Sci USA. 2025 May 27;122(21):e2417224122. PMID: 40397680
  5. Soni P, Sharma SM, Pieper AA, Paul BD, Thomas B. Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease Neurotherapeutics. 2025 Apr;22(3):e00586. PMID: 40199685
  6. Sridharan PS, Koh Y, Miller K, Chakraborty S, Jamuna Tripathi S, Kee T, Chaubey K, Vázquez-Rosa E, Barker S, Leon Alvarado RA, Franke K, Cintrón-Pérez CJ, Dhar M, Shin MK, Flanagan M, Castellani RJ, Gefen T, Bykova M, Cheng F, Wilson BM, Fujioka H, Kang DE, Woo JAA, Paul BD, Qi X, Pieper AA. Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury. Cell Rep Med, 2024. Sep 17;5(9):101715. PMID: 39241772
  7. Paul BD, Pieper AA. Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease. Curr Opin Chem Biol. 2024 Aug 13;82:102511. PMID: 39142018 
  8. Lanzillotta C, Tramutola A, Lanzillotta S, Greco V, Pagnotta S, Sanchini C, Di Angelantonio S, Forte E, Rinaldo S, Paone A, Cutruzzolà F, Cimini FA, Barchetta I, Cavallo MG, Urbani A, Butterfield DA, Di Domenico F, Paul BD, Perluigi M, Duarte JMN, Barone E.Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β Redox Biol. 2024 Jul;73:103221. PMID: 38843768 
  9. Paul BD, Pieper AA. Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain. Biomolecules. 2024 Jan 28;14(2):155. PMID: 38397392 
  10. Hydrogen sulfide: Recent development of its dual donors and hybrid drugs. Xu S, Shieh M, Paul BD, Xian M. Br J Pharmacol. 2023 Aug 8:10.1111/bph.16211. PMID: 37553774 
  11. Tyagi R, Chakraborty S, Tripathi SJ, Jung IR, Kim SF, Snyder SH, Paul BD. Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism. iScience. 2023 Jun 24;26(7):107199. PMID: 37456841 
  12. Peng YJ, Nanduri J, Wang N, Kumar GK, Bindokas V, Paul BD, Chen X, Fox AP, Vignane T, Filipovic MR, Prabhakar NR. Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78. Sci Adv. 2023 Jul 7;9(27):eadf3026. doi: 10.1126/sciadv.adf3026. PMID: 37406126 
  13. Tripathi SJ, Chakraborty S, Miller E, Pieper AA, Paul BD. Hydrogen sulfide signalling in neurodegenerative diseases. Br J Pharmacol. 2023 Jun 20:10.1111/bph.16170. doi: 10.1111/bph.16170. PMID: 37338307 
  14. Paul BD, Pieper AA. Protective Roles of Hydrogen Sulfide in Alzheimer's Disease and Traumatic Brain Injury. Antioxidants (Basel). 2023 May 13;12(5):1095. doi: 10.3390/antiox12051095.
  15. Barker S, Paul BD, Pieper AA. Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury. Biomedicines. 2023 Apr 11;11(4):1154. doi: 10.3390/biomedicines11041154. PMID: 37189772 
  16. Paul BD. DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease. Cell. 2022 Oct 13;185(21):3854-3856. PMID: 36240738 
  17. Paul BD, Sbodio JI, Snyder SH. Mutant Huntingtin Derails Cysteine Metabolism in Huntington's Disease at Both Transcriptional and Post-Translational Levels. Antioxidants (Basel). 2022 Jul 27;11(8):1470. PMID: 36009188 
  18. Vasavda C, Xu R, Liew J, Kothari R, Dhindsa RS, Semenza ER, Paul BD, Green DP, Sabbagh MF, Shin JY, Yang W, Snowman AM, Albacarys LK, Moghekar A, Pardo-Villamizar CA, Luciano M, Huang J, Bettegowda C, Kwatra SG, Dong X, Lim M, Snyder SH. Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv. 2022 Aug 5;8(31):eabo5633. PMID: 35921423 
  19. Latour YL, Sierra JC, Finley JL, Asim M, Barry DP, Allaman MM, Smith TM, McNamara KM, Luis PB, Schneider C, Jacobse J, Goettel JA, Calcutt MW, Rose KL, Schey KL, Milne GL, Delgado AG, Piazuelo MB, Paul BD, Snyder SH, Gobert AP, Wilson KT. Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation. JCI Insight. 2022 Jun 22;7(12):e155338. PMID: 35579952 
  20. Vasavda C, Semenza ER, Liew J, Kothari R, Dhindsa RS, Shanmukha S, Lin A, Tokhunts R, Ricco C, Snowman AM, Albacarys L, Pastore F, Ripoli C, Grassi C, Barone E, Kornberg MD, Dong X, Paul BD, Snyder SH. Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. Sci Signal. 2022 May 10;15(733):eabh3066. PMID: 35536885 
  21. Paul BD, Lemle MD, Komaroff AL, Snyder SH. Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2024358118. PMID: 34400495 https://www.theatlantic.com/health/archive/2023/07/chronic-fatigue-long-covid-symptoms/674834/
  22. How covid brain fog may overlap with ‘chemo brain’ and Alzheimer’s, The Washington Post (March 27, 2022)
  23. Giovinazzo D, Bursac B, Sbodio JI, Nalluru S, Snowman AM, Whiteman M, Filipovic MR, Snyder SH* and Paul BD*. Hydrogen sulfide mediates neuroprotection in Alzheimer’s disease by sulfhydration of GSK3β and inhibition of Tau hyper-phosphorylation. Proc Natl Acad Sci USA. 2021. Jan 26;118(4):e2017225118. PMID: 33431651. Rotten Egg Gas Could Guard Against Alzheimer’s Disease (hopkinsmedicine.org)
  24. Paul BD*, Lemle MD, Komaroff AL and Snyder SH* Redox Imbalance Links COVID-19 and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome. Proc Natl Acad Sci USA. 2021. Aug 24;118(34):e2024358118. (*Corresponding). PMID: 34400495.
  25. Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Xu R, Saavedra H, Snowman AM, Ricco C, Albacarys LK , Sbodio JI, Sedlak TW,  Paul BD* and Snyder SH. Bilirubin links heme catabolism to neuroprotection by scavenging superoxide radicals.Cell Chem Biol. 2019; 26(10):1450-1460 (*Corresponding). PMID: 31353321. More Than Just Jaundice: Mouse Study Shows Bilirubin May Protect The Brain (hopkinsmedicine.org)
  26. Zivanovic J, Kouroussis E, Kohl J, Adhikari B,  Schot-Roux S, Thomas D, Miljkovic J, Bursac B, Petrovic D, Jung Y, Miler M, Mitchell SJ,  Milosevic V, Gomes EJ, Benhar M, Gonzales-Zorn B, Ivanovic-Burmazovic I, Torregrossa R, Mitchell JR, Whiteman M, Schwarz G, Snyder SH, Paul BD, Carroll KS, Filipovic MR. Selective persulfide detection reveals evolutionarily conserved anti-aging effects of s-sulfhydration. Cell Metab. 2019; 30(6):1152-1170. PMID: 31735592.
  27. Sedlak TW#, Paul BD#, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH and Sawa A. The glutathione cycle shapes synaptic glutamate activity Proc Natl Acad Sci USA. 2019; 116(7):2701-2706.  (#Co-first author). PMID: 30692251.
  28. Sbodio JI#, Snyder SH* and Paul BD#*. Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington’s disease. Proc Natl Acad Sci USA. 2018; 115(4):780-785. PMID: 29317536. (#Equal contribution,*Corresponding). [A New Signaling Pathway Involving the Golgi Apparatus Identified in Cells With Huntington’s Disease (hopkinsmedicine.org)
  29. Sbodio JI#, Snyder SH* and Paul BD#*. Transcriptional control of amino acid homeostasis is disrupted in Huntington’s disease.  Proc Natl Acad Sci USA. 2016; 113(31):8843-8848. PMID: 27436896. (#Equal contribution, *Corresponding).  New Evidence: How Amino Acid Cysteine Combats Huntington’s Disease - 07/26/2016 (hopkinsmedicine.org)
  30. Sbodio JI, Paul BD, Machamer C and Snyder SH. Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's Disease. Cell Rep. 2013; 4(5):890-897. PMID: 24012756.
  31. Paul BD, Sbodio JI, Xu R, Vandiver MS, Cha JY, Snowman AM and Snyder SH. Cystathionine g-lyase deficiency mediates neurodegeneration in Huntington’s disease. Nature. 2014; 509(7498):96-100. PMID: 24670645. Brain Degeneration In Huntington’s Disease Caused By Amino Acid Deficiency - 03/26/2014 (hopkinsmedicine.org)
  32. Paul BD and Snyder SH. H₂S signaling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol. 2012; 13(8):499-507.PMID: 22781905. (Cover page article).
  33. Paul BD and Snyder SH. The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ. 2010; 17(7):1134-1140. PMID: 19911007.

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