Valina Dawson PhD

Professor of Neurology, Neuroscience, and Physiology


Wang, Y., R. An, G.K. Umanah, H. Park, K. Nambiar, S.M. Eacker, B.W. Kim, L. Bao, M.M. Harraz, C. Chang, R. Chen, J.E. Wang, T-I Kam, J.S. Jeong, Z. Xie, S. Neifert, J. Qian, S.A. Andrabi, S. Blackshaw, H. Zhu, H. Song, G. Ming, V.L. Dawson and T.M. Dawson. “A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.” PMID: 27846469 Science Oct 7;354(6308). pii: aad6872 (2016).

Mao, X., T. Ou, S.S. Karuppagounder, T-I Kam, X. Yin, Y. Xiong, P. Ge, G.E. Umanah, S. Brahmachari, J.-H. Shin, H.C. Kang, J. Zhang, J. Xu, R. Chen, H. Park, S.A. Andrabi, S.U. Kang, X. Yin, R.A. Goncalves, Y. Liang, S. Zhang, C. Qi, S. Lam, J.A. Keiler, J. Tyson, D. Kim, N. Panicker, S.P. Yun, C.J. Workman, D.A.A. Vignali, P. Ge, V.L. Dawson, H.S. Ko, T.M. Dawson. “Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3.” PMID: 27708076, DOI: 10.1126/science.aah3374 Science 353 aah3374 (2016).

Liddelow, S.A., K.A. Guttenplan, L.E. Clarke, F.C. Bennett, C.J. Bohlen, L. Schirmer, M.L. Bennett, A.E. Münch, W.S. Chung, T.C. Peterson, D.K. Wilton, A. Frouin, B.A. Napier, N. Panicker, M. Kumar, M.S. Buckwalter, D.H. Rowitch, V.L. Dawson, T.M. Dawson, B. Stevens, B.A. Barres. “Neurotoxic reactive astrocytes are induced by activated microglia.” PMID: 28099414 [Epub Jan 18] doi: 10.1038/nature21029 Nature (2018).

Umanah, G.K.E., M. Pignatelli, X. Yin, R. Chen, J. Crawford, S. Neifert, L. Scarffe, A.A. Behensky, N. Guiberson, M. Chang, E. Ma, J.W. Kim, C.C. Castro, X. Mao, L. Chen, S.A. Andrabi, M.V. Pletnikov, A.E. Pulver, D. Avramopoulos, A. Bonci, D. Valle, *T.M. Dawson and *V.L. Dawson. “Thorase variants are associated with defects in glutamatergic signaling that can be rescued by Perampanel.” Science Trans. Med. Vol. 9, Issue 420, eaah4985 DOI: 10.1126/scitranslmed.aah4985. *Both authors contributed equally (2017).

Xiong, Y., S. Neifert, S.S. Karuppagounder, Q. Liu, J.N. Stankowski, B.D. Lee, H.S. Ko, Y. Lee, J.C. Grima, X. Mao, H. Jiang, S-U Kang, D. Swing, L. Iacovitti, L. Tessarollo, T.M. Dawson and V.L. Dawson. ““Robust kinase- and age-dependent dopaminergic neurodegeneration in LRRK2 G2019S transgenic mice.” [Epub Jan 2018] PMID: 29386392 Proc Natl Acad Sci U S A. (2018).

Yun, S.P., T-I Kam, N. Panicker, S.M. Kim, Y. Oh, J-S Park, S-H Kwon, Y.J. Park, S.S. Karuppagounder, H. Park, S. Kim, N. Oh, N.A. Kim, S. Lee, S. Brahmachari, X. Mao, J.H. Lee, M. Kumar, D. An, S-U Kang, Y. Lee, K.C. Lee, D.H. Na, D. Kim, S.H. Lee, V.V. Roschke, S.A. Liddelow, Z. Mari, B.A. Barres, V.L. Dawson, S. Lee, H.S. Ko and T.M. Dawson. “Block of A1 reactive astrocyte conversion is neuroprotective in models of Parkinson’s disease.” PMID: 29892066 PMCID: PMC6039259; Nature Medicine (2018).

Kam, T-I, X. Mao, H. Park, S-C Chou, S.S. Karuppagounder, G.E. Umanah, S.P.Yun, S. Brahmachari, N. Panicker, R. Chen, S.A. Andrabi, C. Qi, G.G. Poirier, O. Pletnikova, J.C. Troncoso, L.M. Bekris, J.B. Leverenz, A. Pantelyat, H.S. Ko, L.S. Rosenthal, V.L. Dawson, and T.M. Dawson. “Poly (ADP-ribose) Drives Pathologic -Synuclein Neurodegeneration in Parkinson’s Disease.” PMID: 30385548; PMCID: PMC6431793; Science 362:557-567 (2018).

Kim, S., S-H Kwon, T-I Kam, N. Panicker, S.S. Karuppagounder, S. Lee, J.H. Lee, W.R. Kim, M. Kook1, C.A. Foss, C. Shen, H. Lee1, S. Kulkarni, P.J. Pasricha, G. Lee, M.G. Pomper, V.L. Dawson, T.M. Dawson and H.S. Ko. “Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s disease.” Neuron in press (2019).