TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells.
Li XJ, Morgan C, Nadar-Ponniah PT, Kolanus W, Doetzlhofer A.
EMBO Rep. 2023 Jul 26:e56562. doi: 10.15252/embr.202256562.
Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea.
Li XJ, Morgan C, Goff LA, Doetzlhofer A.
Sci Adv. 2022 Feb 11;8(6):eabj7651. doi: 10.1126/sciadv.abj7651.
The Notch Ligand Jagged1 Is Required for the Formation, Maintenance, and Survival of Hensen's Cells in the Mouse Cochlea.
Chrysostomou E, Zhou L, Darcy YL, Graves KA, Doetzlhofer A*, Cox BC* (co-corresponding authors*).
J Neurosci. 2020 Dec 2;40(49):9401-9413. doi: 10.1523/JNEUROSCI.1192-20.2020.
LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
Li XJ, Doetzlhofer A.
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22225-22236. doi: 10.1073/pnas.2000417117.
let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear.
Evsen L, Li X, Zhang S, Razin S, Doetzlhofer A.
Development. 2020 Aug 14;147(15):dev183384. doi: 10.1242/dev.183384.
A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea.
Prajapati-DiNubila M, Benito-Gonzalez A, Golden EJ, Zhang S, Doetzlhofer A.
Elife. 2019 Jun 12;8:e47613. doi: 10.7554/eLife.47613.
Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.
Doetzlhofer A, Avraham KB.
Semin Cell Dev Biol. 2017 May;65:69-79. doi: 10.1016/j.semcdb.2016.11.002.
Canonical Notch signaling plays an instructive role in auditory supporting cell development.
Campbell DP, Chrysostomou E, Doetzlhofer A.
Sci Rep. 2016 Jan 20;6:19484. doi: 10.1038/srep19484.
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.
Golden EJ, Benito-Gonzalez A, Doetzlhofer A.
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73. doi: 10.1073/pnas.1501077112.
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling.
Benito-Gonzalez A, Doetzlhofer A.
J Neurosci. 2014 Sep 17;34(38):12865-76. doi: 10.1523/JNEUROSCI.1494-14.2014.
Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea.
Korrapati S, Roux I, Glowatzki E, Doetzlhofer A.
PLoS One. 2013 Aug 30;8(8):e73276. doi: 10.1371/journal.pone.0073276.
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.
Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N.
Dev Cell. 2009 Jan;16(1):58-69. doi: 10.1016/j.devcel.2008.11.008.
PMID: 19154718 Free PMC article.
Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells.
White PM*, Doetzlhofer A*, Lee YS, Groves AK, Segil N (co-first authors*).
Nature. 2006 Jun 22;441(7096):984-7. doi: 10.1038/nature04849