Ahmet Hoke MD, PhD
Professor of Neurology and Neuroscience, Director of Neuromuscular Division
ahoke@jhmi.edu
Telephone Number: 410-955-2227
Fax Number: 410-502-5459
Johns Hopkins Hospital
855 N. Wolfe St.
Baltimore, MD 21205
Room: Rangos 235
Telephone Number: 410-955-2227
Fax Number: 410-502-5459
Johns Hopkins Hospital
855 N. Wolfe St.
Baltimore, MD 21205
Room: Rangos 235
Areas of Research
Developmental NeuroscienceCellular + Molecular Neuroscience
Neurobiology of Disease
Graduate Program Affiliations
Neurobiology of peripheral neuropathies; development and regeneration of the peripheral nervous system
My laboratory is interested in basic biology of peripheral axons and Schwann cells and disorders affecting the peripheral nervous system. We use in vitro and in vivo models of peripheral neuropathies (HIV-associated sensory neuropathies, chemotherapy-induced toxic neuropathies and diabetic neuropathy) to study the mechanism of axonal damage and identify therapeutic targets for drug development. In addition, we study mechanisms of axonal degeneration and regeneration in traumatic injury and develop nanofiber based nerve graft conduits. We utilize engineered stem cells as therapeutic gene delivery tools to promote axonal regeneration in chronically denervated nerves as seen traumatic injuries and many degenerating disorders of the peripheral nervous system such as amyotrophic lateral sclerosis and inherited neuropathies.