Johns Hopkins School of Medicine

Molecular Mechanisms of Neuronal Plasticity 

The ability of the microRNA system to regulate protein translation in the vicinity of synapses indicates it is well-positioned to play a central role in regulating synaptic plasticity.  Accordingly, we are focusing on understanding how this system regulates synaptic function.  In particular, we have identified the translin/trax RNAse complex as a key regulator of microRNA processing and are using genetically engineered mice that lack this complex to understand its role in neuronal function.  For example, these mice display defects in responsiveness to cocaine and in certain forms of synaptic plasticity.  Using a combination of behavioral and molecular approaches, we are conducting studies aimed at understanding how the microRNA system regulates these processes.