John Laterra MD, PhD

Professor of Neurology

Kim KJ, Wang L, Su, YC, Gillespie GY, Salhotra A, Lal B and Laterra J.  Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res, 12(4):1292-1298, 2006. PMID; 16489086

Binning MJ*, Niazi T*, Pedone CA, Lal B,  Eberhart CG, Kim J, Laterra J, and Fults DW., Hepatocyte Growth Factor and Sonic Hedgehog Expression in Cerebellar Neural Progenitor Cells Costimulate Medulloblastoma Initiation and Growth. Cancer Res, 68:7838-7845, 2008. PMID: 18829539; PMCID: PMC2638505

Sun P, Xia S, Lal B, Egerhart CG, Quinones-Hinojosa A, Maciaczyk J, Matsui W, DiMeco F, Piccirillo SM, Vescovi AL, Laterra J.  DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation.  Stem Cells, 2009 Jul;27(7):1473-86.  PMID: 19544453.  PMCID: PMC2935595.

Ying M, Sang Y, Li Y, Guerrero-Cazares H, Quinones-Hinojosa A, Vescovi AL, Eberhart CG, Xia S, Laterra J.  Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells.  Ying M, Sang Y, Li Y, Guerrero-Cazares H, Quinones-Hinojosa A, Vescovi AL, Eberhart CG, Xia S, Laterra J., Stem Cells. 29:20-31, 2011. PMID:21280156.  PMCID: PMC3516843.

Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, Xia S, Trageser D, Guerrero-Cázares H, Eberhart CG, Quiñones-Hinojosa A, Scheffler B, Laterra J. c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A. 108:9951-6, 2011PMID: 21628563.  PMCID:  PMC3116406.

Li Y, Laterra J. Cancer stem cells: distinct entities or dynamically regulated phenotypes?  Cancer Res. 72:576-80, 2012. PMID:  22298594; PMCID:  PMC3271803.

Lopez-Bertoni H, Lal B, Li A, Caplan M, Guerrero-Cazares H, Eberthart C, Quinones-Hinojosa, Glas M, Scheffler B, Laterra J*, Li Yu*.  DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2. Oncogene. Oct. 20, 2014, epub ahead of print.

Ying, M, Tilghman J, Wei Y, Guerrero-Cazares H, Quinones-Hinojosa A, Ji H, Laterra J. KLF9 Inhibits Glioblastoma Stemness through Global Transcription Repression and Integrin-α6 Inhibition. J. Biol. Chem., Oct. 6, 2014, epub ahead of print.

Lopez-Bertoni H, Lal B, Michelson N, Guerrero-Cázares H, Quiñones-Hinojosa A, Li Y, and Laterra J. Epigenetic Modulation of a miR-296-5p:HMGA1 Axis Regulates Sox2 expression and Glioblastoma Stem Cells. Oncogene, 35:4903-13, 2016

Tilghman J, Schiapparelli P, Lal B, Ying M, Quinones-Hinojosa A, Xia S, Laterra J. Regulation of Glioblastoma Tumor-propagating Cells by Integrin Partner tetraspanin CD151.  Neoplasia. 18(3):185-98, 2016

Lopez-Bertoni H, Kozielski KL, Rui L, Lal B, Vaughan H, Wilson DR, Mihelson N, Eberhart CG, Laterra J, Green JJ.  Bioreducuble Polymeric nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival. Nano Lett. 18:4086-4094, 2018