Johns Hopkins School of Medicine

Complete list of publication can be found below. 

https://www.ncbi.nlm.nih.gov/myncbi/1deyyuflJkcAm/bibliography/public/

Selected Publications

2023

Kim MS, Ra EA, Kweon SH, Seo BA, Ko HS, Oh Y, Lee G. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell 2023 Jul 6;30(7):973-986.e11.

2022

Sun C, Kannan S, Choi IY, Lim H, Zhang H, Chen GS, Zhang N, Park S-H, Serra C, Lyer SR, Lloyd TE, Kwon C, Lovering RM, Lim SB, Andersen P, Wagner KR, Lee G. Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment. Cell Stem Cell 2022 Apr 7;29(4):610-619.e5. 

2021

Lee HJ, Lee JJ, Park NY, Dubey SK, Kim TY, Ruan K, Lim SB, Park SH, Ha SW, Kovlyagina I, Kim YT, Kim SJ, Oh YH, Kim HS, Kang SU, Song MR, Lloyd TE, Maragakis NJ, Hong YB, Eoh HJ, Lee G. Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nature Neuroscience. 2021 Dec;24(12):1673-1685

Choi IY, Lim H, Huynh A, Schofield J, Cho HJ, Lee H, Andersen P, Shin JH, Heo WD, Hyun SH, Kim YJ, Oh Y, Kim H, Lee G. Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency. Biomaterials. 2021 Feb;269:120222. doi: 10.1016/j.biomaterials.2020.120222. Epub 2020 Jul 15. PMID: 32736809

2020

Choi IY, Lim H, Cho HJ, Oh Y, Chou BK, Bai H, Cheng L, Kim YJ, Hyun S, Kim H, Shin JH, Lee G. Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors. Elife. 2020 Feb 3;9:e46981. doi: 10.7554/eLife.46981. PMID: 32011235

Sun C, Choi IY, Rovira Gonzalez YI, Andersen P, Talbot CC Jr, Iyer SR, Lovering RM, Wagner KR, Lee G. Duchenne muscular dystrophy hiPSC-derived myoblast drug screen identifies compounds that ameliorate disease in mdx mice. JCI Insight. 2020 Jun 4;5(11):e134287. doi: 10.1172/jci.insight.134287. PMID: 32343677 

2019

Mukherjee-Clavin B, Mi R, Kern B, Choi IY, Lim H, Oh Y, Lannon B, Kim KJ, Bell S, Hur JK, Hwang W, Che YH, Habib O, Baloh RH, Eggan K, Brandacher G, Hoke A, Studer L, Kim YJ, Lee G. Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder.  Nature Biomedical Engineering 2019 Apr 8. doi: 10.1038/s41551-019-0381-8. [Epub ahead of print] PMID: 30962586

2018

Kim S, Yun SP, Lee S, Umanah GE, Bandaru VVR, Yin X, Rhee P, Karuppagounder SS, Kwon SH, Lee H, Mao X, Kim D, Pandey A, Lee G, Dawson VL, Dawson TM, Ko HS. GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):798-803. PMID: 29311330

2017

Oh Y, Zhang F, Wang Y, Lee EM, Choi IY, Lim H, Mirakhori F, Li R, Huang L, Xu T, Wu H, Li C, Qin C-F, Wen Z, Wu Q-F, Tang H, Xu Z, Jin P, Song H, Ming G-L, Lee G. Zika virus directly infects human peripheral neurons and induces cell death. Nature Neuroscience. 2017 2017 Sep;20(9):1209-1212. PMID: 28758997

Kurapati S, Sadaoka T, Rajbhandari L, Jagdish B, Shukla P, Ali MA, Kim YJ, Lee G, Cohen JI, Venkatesan A.  Capturing Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation. J Virol. 2017 91, PMID: 28637759

2016 

Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G. Functional coupling with cardiac muscle promotes maturation of hPSC-derived sympathetic neurons. Cell Stem Cell PMID: 27320040 

Choi IY, Lim HT, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim HS, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wager K, Lee G. Concordant but varied phenotypes among patient-specific myoblasts of Duchenne muscular dystrophy revealed by a human iPSC-based model. Cell Reports PMID: 27239027

Nguyen TT, Park WS, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, Hahn KM, Meyer T, Heo WD. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proc Natl Acad Sci U S A. 2016 113:10091-6 PMID: 27555588 

Smith AS, Davis J, Lee G, Mack DL, Kim DH. Muscular dystrophy in a dish: engineered human skeletal muscle mimetics for disease modeling and drug discovery. Drug Discov Today. 2016 21:1387-98 PMID: 27109386

Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016 22:1421-1427 PMID: 27841875

2015

Choi J, Lee S, Mallard W, Clement K, Tagliazucchi GM, Lim H, Choi IY, Ferrari F, Tsankov AM, Pop R, Lee G, Rinn JL, Meissner A, Park PJ, Hochedlinger K. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nat Biotechnol. PMID: 26501951

Laguesse S, Creppe C, Nedialkova DD, Prévot PP, Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA, Godin JD, Nguyen L. A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.Developmental Cell. 2015 35:553-67. PMID 26651292.

Kim YJ, Lee G*. Cellular stage specific functional analysis of REX1: In human embryonic stem cells. Proteomics. 2015 Jul;15(13):2147-9. PMID 26058466

2014

Kim YJ, Lim HT, Li Z, Oh Y, Kovlyagina I, Choi IY, Dong XZ, Lee G*. Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor Cell Stem Cell. 2014 15:497-506. PMID 25158936,  Previewed by Dr. Sommer’s group

Choi IY, Lim HT, Lee G*. Efficient generation human induced pluripotent stem cells from human somatic cells with sendai-virus. 2014 86:51406. PMID: 24798302 JoVE. 

Lim HT, Choi IY, Lee G*. Profiling individual human embryonic stem cells by quantitative RT-PCR. 2014 87:51408. PMID: 24961819 JoVE