Brady Maher PhD

Associate Professor of Psychiatry and Behavior Sciences

Page SC, Hamersky GR, Gallo RA, Rannals MD, Calcaterra NE, Campbell MN, Mayfield B, Briley A, Phan BN, Jaffe AE, Maher BJ. The schizophrenia and autism associated gene, Transcription Factor 4 (TCF4) regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner. Molecular Psychiatry 2017 (in press).

Rannals MD, Page SC, Campbell MN, Gallo RA, Mayfield B, Maher BJ. Neurodevelopmental Models of Transcription Factor 4 Deficiency Converge on a Common Ion Channel  as a Potential Therapeutic Target for Pitt Hopkins Syndrome. Rare Diseases Aug 5 (2016).

Qian X, Nguyen HN, Song MM, Hadiono C, Odgen SC, Hammack C, Yao B, Hamersky GR, Jacob F, Zhong C, Yoon K, Jeang W, Lin L, Li Y, Thakor J, Berg DA, Zhang C, Kang E, Chickering M, Nauen D, Ho C, Wen Z, Christian KM, Shi P, Maher BJ, Wu H, Jin P, Tang H, Song H, Ming G. Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell May 19 (2016).

Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay RD, Kleinman JE, Weinberger DR. A Human-specific AS3MT isoform and BORCS7 are Molecular Risk Factors in the 10z24.32 Schizophrenia Locus. Nature Medicine June 22 (2016).

Rannals MD, Cerceo-Page, S, Campbell M, Hamersky G, Briley A, Gallo R, Hyde TM, Kleinman JE, Shin JH, Jaffe AE, Weinberger DR, Maher BJ. Psychiatric risk gene Transcription Factor 4 Regulates the Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1. Neuron April 6 (2016).

Calcaterra N, Hoeppner D, Wei H, Jaffe A, Maher BJ+, Barrow J+. The Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. Scientific Reports Feb (2016) +corresponding author

Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, Brandon NJ, Maher BJ, Kamiya A. Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Molecular Psychiatry Jan 5 (2016).

Jaffe AE, Shin J, Collado-Torres L, Leek JT., Tao R, Li C, Gao Y, Jia Y, Maher BJ, Hyde TM, Kleinman JE, Weinberger DR. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution. Nature Neuroscience Dec 15 (2014).

Maher BJ and LoTurco JJ. Disrupted-in-Schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS One. 2012; 7(3): e34053.

Maher BJ, McGinley MJ and Westbrook GL. Experience-dependent maturation of the glomerular microcircuit. PNAS.2009; 106: 16865-16870.