Jeremy Nathans MD, PhD

Professor of Molecular Biology and Genetics

Yu, H., Ye, X., Guo, N. and Nathans, J. (2012) Frizzled2 and Frizzled7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.  Development 139: 4383-4394.

 Wang, Y., Rattner, A., Zhou, Y., Williams, J., Smallwood, P.M., and Nathans, J. (2012) Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.  Cell 151: 1332-1344.

 Wu, H., Williams, J., and Nathans, J. (2012) Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling.  eLife 1:e00181.

Badea, T.C., Williams, J., Smallwood, P., Shi, M., Motajo, O., and Nathans, J. (2012) Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.  Journal of Neuroscience 32: 995-1007.

Julius, D. and Nathans, J. (2012) Signaling by Sensory Receptors. In Perspectives in Signal Transduction.  Series: Cold Spring Harbor Perspectives in Biology. (Cantley, L., Hunter, T., Sever, R., and Thorner, J.W., eds).  Cold Spring Harbor, NY: Cold Spring Harbor Press, pp 1-14.  4(1):a005991.

Cahill, H.,  Rattner, A., and Nathans, J. (2011) Preclinical assessment of central nervous system drug action using eye movements in mice.  Journal of Clinical Investigation 121: 3528-3541.

Badea, T., and Nathans, J. (2011) Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling.  Vision Research 51:269-279.

Ye, X., Wang, Y.,  Rattner, A., and Nathans, J. (2011) Genetic mosaic analysis reveals a major role for frizzled4 and frizzled8 in controlling ureteric growth in the developing kidney.  Development 138: 1161-1172.

Yu, H., Smallwood, P.M., Wang, Y., Vidaltamayo, R., Reed, R., and Nathans, J. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.  Development 137:3707-3717.

Wang, Y., Chang, H., and Nathans, J. (2010)  When whorls collide: the development of hair patterns in frizzled6 mutant mice.  Development 137: 4091-4099.

Ye, X., Wang, Y., Cahill, H., Yu, Y., Badea, T.C., Smallwood, P.M., Peachey, N.S., and Nathans, J.  (2009)  Norrin, Frizzled4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.  Cell 139: 285-298.

Badea, T.C., Hua, L.Z., Smallwood, P.M., Williams, J., Rotolo, T., Ye, X., and Nathans, J. (2009) New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. Public Library of Science One 16: e7859. 

Rattner, A., and Nathans, J. (2008) The genomic response of the retinal pigment epithelium to light damage and retinal detachment.  Journal of Neuroscience 28: 9880-9889.

Liu, C., and Nathans, J.  (2008) An essential role for Frizzled5 in mammalian ocular development: loss of Frizzled5 leads to microphthalmia, delayed closure of the optic fissure, persistence of the hyaloid vasculature, and a late retinal degeneration. Development 135: 3567-3576.

Jacobs, G.H., Williams, G.A., Cahill, H., and Nathans, J. (2007) Emergence of novel color vision in mice engineered to express a human cone photopigment.  Science 315: 1723-1725.