Johns Hopkins School of Medicine

Zhang N, Westerhaus A, Wilson M, Wang E, Goff L, Sockanathan S. Physiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function. EMBO J. 2024. Epub 2024/06/26. doi: 10.1038/s44318-024-00156-8. (PMID: 38918634).

Daudelin D, Westerhaus A, Zhang N, Leyder E, Savonenko A and Sockanathan S. Loss of GDE2 leads to complex behavioral changes including memory impairment. Behavioral and Brain Functions 2024 20:7. doi.org/10.1186/s12993-024-00234-1.

Levy-Myers R, Daudelin D, Na CH, and Sockanathan S. An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function. Science Adv. 2023 Jun; 9(25): eadg2067.  doi: 10.1126/sciadv.adg2067. PMCID: PMC10289663.

Westerhaus A, Joseph T, Meyers AJ, Jang Y, Na CH, Cave C, Sockanathan S. The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis. Acta Neuropathol Commun. 2022 May 12;10(1):73. doi: 10.1186/s40478-022-01376-x. PMID: 35550203; PMCID: PMC9102353.

Nakamura M, Li Y, Choi BR, Matas-Rico E, Troncoso J, Takahashi C, Sockanathan S. GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein. Sci Transl Med. 2021 Mar 17;13(585):eabe6178. doi: 10.1126/scitranslmed.abe6178. PMID: 33731436.

Choi BR, Dobrowolski M, Sockanathan S. GDE2 expression in oligodendroglia regulates the pace of oligodendrocyte maturation. Dev Dyn. 2020 Oct 23. doi: 10.1002/dvdy.265. PMID: 33095500.

Choi BR, Cave C, Na CH, Sockanathan S. GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation. Cell reports. 2020 May 5;31(5):107540. PMID: 32375055 PMCID: PMC7254694 DOI: 10.1016/j.celrep.2020.107540.

Dobrowolski M, Cave C, Levy-Myers R, Lee C, Park S, Choi BR, Xiao B, Yang W, Sockanathan S. GDE3 regulates oligodendrocyte precursor proliferation via release of soluble CNTFRα. Development. 2020 Jan 23;147(2). pii: dev180695. doi: 10.1242/dev.180695. PMID: 31932351; PMCID: PMC6983723.

Cave C, Sockanathan S. Transcription factor mechanisms guiding motor neuron differentiation and diversification. Curr Opin Neurobiol. 2018 Dec;53:1-7. doi: 10.1016/j.conb.2018.04.012. Epub 2018 Apr 23. Review. PubMed PMID: 29694927; PubMed Central PMCID: PMC6196124.

Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, Sockanathan S. GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener. 2017 Jan 19;12(1):8. doi: 10.1186/s13024-017-0148-1. PubMed PMID: 28103900; PubMed Central PMCID: PMC5244531.

Cave C, Sockanathan S. Transcription Factor Hand-offs "Enhance" Motor Neuron Differentiation. Neuron. 2016 Dec 21;92(6):1149-1151. doi: 10.1016/j.neuron.2016.12.009. PubMed PMID: 28009267.

Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites. Neuron. 2016 Aug 3;91(3):561-73. doi: 10.1016/j.neuron.2016.06.017. Epub 2016 Jul 7. PubMed PMID: 27397520; PubMed Central PMCID: PMC5580817.

Hatori Y, Yan Y, Schmidt K, Furukawa E, Hasan NM, Yang N, Liu CN, Sockanathan S, Lutsenko S. Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun. 2016 Feb 16;7:10640. doi: 10.1038/ncomms10640. PubMed PMID: 26879543; PubMed Central PMCID: PMC4757759.

Yan Y, Wladyka C, Fujii J, Sockanathan S. Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015 May 6;6:7006. doi: 10.1038/ncomms8006. PubMed PMID: 25943695; PubMed Central PMCID: PMC4432624.

Andermatt I, Wilson NH, Bergmann T, Mauti O, Gesemann M, Sockanathan S, Stoeckli ET. Semaphorin 6B acts as a receptor in post-crossing commissural axon guidance. Development. 2014 Oct;141(19):3709-20. doi: 10.1242/dev.112185. Epub 2014 Sep 10. PubMed PMID: 25209245; PubMed Central PMCID: PMC6514406.

Choi J, Park S, Sockanathan S. Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons. Development. 2014 Mar;141(5):1151-60. doi: 10.1242/dev.104505. Epub 2014 Feb 6. PubMed PMID: 24504337.

Park S, Lee C, Sabharwal P, Zhang M, Meyers CL, Sockanathan S. GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science. 2013 Jan 18;339(6117):324-8. doi: 10.1126/science.1231921. PubMed PMID: 23329048; PubMed Central PMCID: PMC3644959.

Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ. A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells. Cancer Res. 2012 Oct 15;72(20):5230-9. doi: 10.1158/0008-5472.CAN-12-1727. Epub 2012 Aug 17. PubMed PMID: 22902413; PubMed Central PMCID: PMC3766319.

Rodriguez M, Choi J, Park S, Sockanathan S. Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation. Development. 2012 Oct;139(20):3870-9. doi: 10.1242/dev.081083. Epub 2012 Sep 5. PubMed PMID: 22951639.

Sabharwal P, Lee C, Park S, Rao M, Sockanathan S. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron. 2011 Sep 22;71(6):1058-70. doi: 10.1016/j.neuron.2011.07.028. Epub 2011 Sep 21. PubMed PMID: 21943603; PubMed Central PMCID: PMC3183458.

Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA, De Vries V, Nowak E, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Noelle RJ. A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. J Exp Med. 2011 Aug 29;208(9):1767-75. doi: 10.1084/jem.20102358. Epub 2011 Aug 22. PubMed PMID: 21859847; PubMed Central PMCID: PMC3171100.

Periz G, Yan Y, Bitzer ZT, Sockanathan S. GDP-bound Galphai2 regulates spinal motor neuron differentiation through interaction with GDE2. Dev Biol. 2010 May 1;341(1):213-21. doi: 10.1016/j.ydbio.2010.02.032. Epub 2010 Mar 1. PubMed PMID: 20197066; PubMed Central PMCID: PMC2854168.

Sockanathan S, Gaiano N. Preview. Meninges Play a RAdical Role in Embryonic Neural Stem Cell Regulation. Cell Stem Cell. 2009 Nov 6;5(5):455-6. doi: 10.1016/j.stem.2009.10.010. PubMed PMID: 19896433.

Yan Y, Sabharwal P, Rao M, Sockanathan S. The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell. 2009 Sep 18;138(6):1209-21. doi: 10.1016/j.cell.2009.06.042. PubMed PMID: 19766572; PubMed Central PMCID: PMC2748999.

Zhuang B, Su YS, Sockanathan S. FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling. Neuron. 2009 Feb 12;61(3):359-72. doi: 10.1016/j.neuron.2008.12.022. PubMed PMID: 19217374; PubMed Central PMCID: PMC2654783.

Ji SJ, Periz G, Sockanathan S. Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. Development. 2009 Jan;136(2):231-40. doi: 10.1242/dev.028043. Epub 2008 Dec 4. PubMed PMID: 19056829; PubMed Central PMCID: PMC2685968.

Rajaii F, Bitzer ZT, Xu Q, Sockanathan S. Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol. 2008 Apr 15;316(2):371-82. doi: 10.1016/j.ydbio.2008.01.041. Epub 2008 Feb 13. PubMed PMID: 18329011.

Ji SJ, Zhuang B, Falco C, Schneider A, Schuster-Gossler K, Gossler A, Sockanathan S. Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons. Dev Biol. 2006 Sep 1;297(1):249-61. doi: 10.1016/j.ydbio.2006.05.015. Epub 2006 May 19. PubMed PMID: 16781703.

Zhuang B, Sockanathan S. Dorsal-ventral patterning: a view from the top. Curr Opin Neurobiol. 2006 Feb;16(1):20-4. doi: 10.1016/j.conb.2005.11.001. Epub 2005 Dec 7. Review. PubMed PMID: 16337785.

Rao M, Sockanathan S. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science. 2005 Sep 30;309(5744):2212-5. doi: 10.1126/science.1117156. PubMed PMID: 16195461.

Rao M, Sockanathan S. Molecular mechanisms of RNAi: implications for development and disease. Birth Defects Res C Embryo Today. 2005 Mar;75(1):28-42. doi: 10.1002/bdrc.20030. Review. PubMed PMID: 15838922.

Rao M, Baraban JH, Rajaii F, Sockanathan S. In vivo comparative study of RNAi methodologies by in ovo electroporation in the chick embryo. Dev Dyn. 2004 Nov;231(3):592-600. doi: 10.1002/dvdy.20161. PubMed PMID: 15376322.