Daniel Weinberger MD

Director and CEO, Lieber Institute for Brain Development. Professor of Psychiatry, Neurology and Neuroscience, McKusick-Nathans Institute of Genetic Medicine




 

  1. Ursini G, Punzi G, Chen Q, Marceno S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G,  Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, and Weinberger DR. Convergence of Placenta Biology and Genetic Risk for Schizophrenia. Nat Med 24:792-801, 2018. 
  2. Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich W, Maher BJ, Deep-Soboslay A; BrainSeq Consortium, Cross AJ, Brandon NJ, Leek JT, Hyde TM, Kleinman JE and Weinberger DR. Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nat Neurosci 21:1117-1125, 2018.
  3. Price AJ, Jaffe AE and Weinberger DR. Cortical cellular diversity and development in schizophrenia. Mol Psychiatry 1: 203-217, 2021.
  4. Mandell KAP, Eagles NJ, Deep-Soboslay A, Tao R, Han S, Wilton R, Szalay AS, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR. Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus. Mol Psychiatry doi: 10.1038/s41380-022-01453-6.
  5. Punzi G, Ursini G, Chen Q, Radulescu E, Tao R, Huuki LA, Di Carlo P, Collado-Torres L, Shin JH, Catanesi R, Jaffe AE, Hyde TM, Kleinman JE, Mackay TFC, Weinberger DR. Genetics and Brain Transcriptomics of Completed Suicide. Am J Psychiatry 3:226-241, 2022.
  6. Zandi PP, Jaffe AE, Goes FS, Burke EE, Collado-Torres L, Huuki-Myers L, Seyedian A, Lin Y, Seifuddin F, Pirooznia M, Ross CA, Kleinman JE, Weinberger DR, Hyde TM. Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways. Nat Neurosci3:381-389, 2022.
  7. Benjamin KJM, Chen Q, Jaffe AE, Stolz JM, Collado-Torres L, Huuki-Myers LA, Burke EE, Arora R,  Feltrin AS, Barbosa AR, Radulescu E, Pergola G, Shin JH, Ulrich WS, Deep-Soboslay A, Tao R, Brainseq Consortium, Hyde TE, Kleinman JE, Erwin JA, Weinberger DR, Paquola ACM.  Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes. Nat Neurosci 11:1559-1568, 2022.
  8. Ursini G, Di Carlo P, Murherjee S, Chen Q, Han S, Kim J, Deyssenroth M, Marsit CJ, Chen J, Hao K, Punzi G, Weinberger DR. Prioritization of potential causative genes for schizophrenia in placenta. Nat Commun14(1):2613, 2023.
  9. Pergola G, Parihar M, Sporteli L, Bharadwaj R, Boruck C, Radulescu E, Bellantuono L, Blasi G, Che Q, Kleinman JE, Wang Y, Sripathy SR, Maher BJ, Monaco A, Rossi F, Shin JH, Hyde TM, Bertolino A, Weinberger DR. Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions. Sci Adv 14:9(15), 2023.
  10. Zhou J, Chen Q, Braun PR, Mandell KAP, Jaffe AE, Tan HY, Hyde TM, Kleinman JE, Potash JB, Shinozaki G, Weinberger DR, Han S. Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders. Proc Natl Acad Sci 119:34, 2022.
  11. Sportelli L, Eisenberg DP, Passiatore R, D’Ambrosio E, Antonucci LA, Bettina JS, Che Q, Goldmen AL, Gregory MD, Griffits K, Hyde TM, Kleinman JE, Pardinas AF, Parihar M, Popolizio T, Rampino A, Shin JH, Veronese M, Ulrich WS, Zink CF, Bertolino A, Howes OD, Berman KF, Weinberger DR, Pergola G. Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo. Nat Commun15:3342, 2024.
  12. Collado-Torres L, Klei L, Liu C, Kleinman JE, Hyde TM, Geschwind DH, Gandal MJ, Devlin B, Weinberger DR. Comparison of gene expression in living and postmortem human brain. medRxivdoi.org/10.1101/2023.11.08.23298172.
  13. Benjamin KJM, Che Q, Eagles NJ, Huuki-Myers LA, Collado-Torres L, Stolz JM, Pertea G, Shin JH, Paquola ACM, Hyde TM, Kleinman JE, Jaffe AE, Han S, Weinberger DR. Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry. Nat Neurosci 27, 1064-1074, 2024.
  14. Borcuk C, Parihar M, Sportelli L, Kleinman JE, Shin JH, Hyde TM, Bertolino A, Weinberger DR, Pergola G. Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk. Neuron. doi.org/10.1016/j.neuron.2024.08.005.
  15. Birnbaum R and Weinberger DR. The Genesis of Schizophrenia: An Origin Story. Am J Psychiatry 181:482-492, 2024.